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Match the antibody result to your celiac question

Each of these answers a different celiac screening question — one antibody, or several together.

A celiac disease test measures antibodies associated with the body's immune response to gluten-related proteins, rather than confirming celiac disease on its own. Shoppers often compare tTG IgA with total IgA, deamidated gliadin peptide antibodies, and endomysial IgA because each result answers a slightly different screening question. Total IgA helps place an IgA antibody result in perspective, while IgG testing offers another antibody type. Start by deciding whether you need a single tTG IgA measurement, deamidated gliadin IgA and IgG results, or a panel that includes total IgA.

How celiac-related antibody tests differ

Tissue transglutaminase (tTG) IgA measures an IgA antibody directed at tissue transglutaminase and is commonly used in celiac-related screening. Total IgA measures the overall amount of immunoglobulin A, helping put a tTG IgA result in perspective when IgA levels are lower than expected. Deamidated gliadin peptide (DGP) IgA and IgG measure antibodies to deamidated gliadin peptides; reporting both antibody classes provides separate IgA and IgG results. Endomysial IgA screening measures another celiac-associated antibody and includes reflex to a titer when the screen is positive. These blood results require clinical interpretation and do not establish a diagnosis by themselves.

Using results thoughtfully

An antibody result is most useful when considered with symptoms, medical history, and the reason for testing. A tTG IgA result without total IgA does not show whether the body's overall IgA level could affect interpretation. DGP IgG supplies an IgG-based result, which differs from an IgA-only measurement. Endomysial IgA screening with reflex to titer first reports a screen and then provides a titer if that screen is positive. Results can be negative or positive for reasons that need professional review, so ongoing digestive symptoms or a concerning result warrants discussion with a qualified clinician.

Celiac Disease FAQ

A celiac disease test in this category measures antibodies associated with celiac-related immune activity, including tTG IgA, DGP IgA, DGP IgG, or endomysial IgA. Some options also measure total IgA. These blood measurements support screening and clinical evaluation, but no single antibody result diagnoses celiac disease by itself.

Total IgA measures the overall amount of immunoglobulin A in blood, which helps interpret a tTG IgA result. When overall IgA is lower than expected, an IgA-based antibody measurement deserves added clinical consideration. The Celiac Disease Comprehensive Panel measures both tTG IgA and total IgA.

tTG IgA and DGP antibodies target different proteins or protein-related targets involved in celiac-related testing. Anti-tTG IgA reports tissue transglutaminase IgA only. Gliadin (Deamidated Peptide) Antibody (IgG, IgA) reports separate DGP IgG and DGP IgA results, adding an IgG antibody class to the comparison.

DGP IgG and DGP IgA are useful when you want results from two antibody classes directed at deamidated gliadin peptides. The paired test distinguishes the IgG result from the IgA result rather than reporting only one. A clinician can relate those findings to total IgA, tTG IgA, symptoms, and other evaluation.

Endomysial Antibody (IgA) Screen with Reflex to Titer first reports an endomysial IgA screen. If the screen is positive, reflex testing provides a titer, which expresses the antibody finding in a further reported measurement. It is a celiac-related antibody screen, not a stand-alone diagnostic determination.

Celiac Disease Comprehensive Panel, Infant measures tTG IgA, total IgA, and DGP IgA. That combination provides a tissue transglutaminase antibody result, an overall IgA measurement, and a deamidated gliadin IgA result. Pediatric testing decisions and interpretation should be reviewed with a qualified clinician.

No, a negative antibody result does not independently rule out celiac disease. Results need to be considered alongside symptoms, medical history, total IgA when relevant, and the specific antibodies measured. Professional review is important when symptoms persist or when there is a strong reason for further evaluation.

No, a positive tTG IgA result is not a diagnosis by itself. It identifies an IgA antibody finding directed at tissue transglutaminase and can inform the next clinical discussion. A qualified clinician considers the result with total IgA, other antibody findings, symptoms, and additional evaluation when appropriate.

Choose Anti-tTG IgA when the question is limited to tissue transglutaminase IgA. Choose the Celiac Disease Comprehensive Panel when you also want total IgA measured. Choose Gliadin (Deamidated Peptide) Antibody (IgG, IgA) when separate DGP IgG and DGP IgA results are the priority.

Ordering & Results FAQ

You'll receive it via email within 60 seconds of your order unless it requires additional processing (only very complex orders do).

Many general wellness test results are typically available online within 2-3 business days. However, some tests will require additional processing time. You will immediately receive an email & SMS notification when your results are available.

We do not share your results with your physician, insurance company, or any other third party.

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