Autoimmune Blood Test Options

An autoimmune blood test measures one or more antibodies, immune-related proteins, or supporting laboratory findings. ANA testing looks for antinuclear antibodies, dsDNA testing measures double-stranded DNA antibodies, and rheumatoid factor and CCP IgG address different antibody signals. Some panels also report C3 complement, sedimentation rate, blood-cell counts, and metabolic measurements. These findings support screening or monitoring; they do not diagnose a condition by themselves.

ANA Screen IFA is a preliminary antinuclear antibody screen with reflex testing to titer and pattern when indicated. Autoimmune Profile combines ANA Screen IFA with dsDNA antibodies and complement component C3C. That combination is useful when an ANA result alone would not answer the question, because dsDNA and C3 provide additional immune-related measurements. Results still require interpretation alongside symptoms and medical history.

ANA titer describes the level of reactivity reported by the assay, while the pattern describes how fluorescence appears in the laboratory test. Those details add information beyond a positive or negative screen and help a clinician place the result in clinical context. A positive ANA does not establish an autoimmune diagnosis, and ANA reactivity can occur outside autoimmune conditions.

Rheumatoid factor and CCP IgG are separate antibody measurements, not interchangeable names for the same result. Rheumatoid Arthritis Diagnostic Panel 1 includes both, allowing the two findings to be considered together when joint-focused symptoms are being evaluated. Rheumatoid factor can be elevated for reasons other than rheumatoid arthritis, so neither a positive nor a negative result should be interpreted as a stand-alone diagnosis.

Anti-dsDNA testing measures antibodies to double-stranded DNA and is often considered alongside ANA findings rather than as a substitute for ANA screening. The Autoimmune Profile includes ANA, dsDNA antibodies, and C3C, while Deluxe Autoimmune Testing adds those measurements to thyroid antibodies, rheumatoid factor, blood counts, and metabolic results. A clinician can weigh those related findings with symptoms and prior results.

Celiac Disease Comprehensive Panel measures tTG IgA and total IgA because total IgA helps interpret an IgA-based tTG result. If total IgA is low, a negative tTG IgA result needs careful clinical interpretation because the antibody response measured by that method could be affected. The panel is a screening tool and does not independently confirm or exclude celiac disease.

Thyroid Peroxidase (TPO) Antibodies measures antibodies against thyroid peroxidase, an enzyme involved in thyroid hormone production. The result indicates antibody reactivity, not thyroid function itself. Deluxe Autoimmune Testing also includes thyroglobulin antibodies, ANA, dsDNA antibodies, rheumatoid factor, C3C, blood counts, and metabolic measurements for people comparing several immune-related laboratory findings.

Deluxe Autoimmune Testing includes a complete blood count to report red cells, white cells, hemoglobin, hematocrit, and platelets, plus metabolic measurements such as creatinine, eGFR, ALT, AST, bilirubin, albumin, and total protein. Those results provide supporting information beyond antibodies. They are not specific to autoimmune disease: hydration, exercise, muscle mass, infections, and many other factors can influence individual values.

An autoimmune blood test starting point depends on the measurements tied to the question. ANA Screen IFA is suited to a preliminary antinuclear antibody screen with titer and pattern reflex testing. Rheumatoid Arthritis Diagnostic Panel 1 focuses on rheumatoid factor and CCP IgG, while Celiac Disease Comprehensive Panel focuses on tTG IgA and total IgA. Deluxe Autoimmune Testing combines several antibody and supporting measurements when multiple areas are being evaluated.

You'll receive it via email within 60 seconds of your order unless it requires additional processing (only very complex orders do).

Many general wellness test results are typically available online within 2-3 business days. However, some tests will require additional processing time. You will immediately receive an email & SMS notification when your results are available.

We do not share your results with your physician, insurance company, or any other third party.