Immune System Test Options

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Start from the part of immunity you're checking

Each of these answers a different immune question — antibody proteins, cell populations, or cell function.

Want your antibody protein levels checked? three results — IgA, IgG, and IgM measured together View Immunoglobulins Panel $268 $214
Following your CD4 to CD8 ratio? reads the ratio alongside the absolute CD4 and CD8 counts behind it View Lymphocyte Subset Panel 4 $206 $165
Want a functional read rather than a count? a single functional immune-cell result, with no antibody or cell counts View Immune Cell Function $1,193 $954
Asking specifically about natural killer cells? natural killer cells only — a percentage and an absolute count View Natural Killer Cells $325 $260

Featured tests

HSA/FSA accepted

Immunoglobulins Panel, Serum

Reveal hidden immune system issues
Diagnose allergies and sensitivities accurately
Clarify the cause of frequent infections

• All lab fees included

-20% $214 about $24 per marker

List price ~~$268~~

HSA/FSA accepted

Lymphocyte Subset Panel 4 (CD4:CD8 Ratio Profile)

Reveal your immune system's strength
Pinpoint the cause of frequent infections
Clarify your body's response to treatments

• All lab fees included

-20% $165 about $9 per marker

List price ~~$206~~

HSA/FSA accepted

Immune Cell Function

Reveal how well your immune system works
Pinpoint why you might feel constantly tired
Expose hidden infections or immune issues

• All lab fees included

-20% $954 about $119 per marker

List price ~~$1,193~~

HSA/FSA accepted

Natural Killer Cells

Checks immune cells fighting infections or cancer
Measures body's natural defense cell levels
Looks at key cells in your immunity

-20% $260

List price ~~$325~~

HSA/FSA accepted

Immunofixation (IFE) and Immunoglobulins Panel (IgG, IgA, IgM), Serum

Detect abnormal antibody protein patterns
Monitor immune system protein levels
Track unusual blood protein changes

HSA/FSA accepted

-20% $499

List price ~~$624~~

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An immune system test compares different parts of immune activity rather than providing one single score. Available options measure antibody proteins IgA, IgG, and IgM; lymphocyte counts and the CD4/CD8 ratio; natural killer cells; or immune cell function. Shoppers often compare these tests when a clinician has raised a question about recurrent illness, an unusual immune-related result, or follow-up of a known concern. Start by deciding whether the question is about antibody levels, lymphocyte populations, natural killer cells, or a functional immune-cell measurement.

What the available measurements describe

IgA, IgG, and IgM are immunoglobulins, also called antibody proteins. The Immunoglobulins Panel, Serum measures all three, helping establish whether their concentrations are within the laboratory’s reference intervals. IgA is commonly considered alongside immune activity at mucosal surfaces, while IgG and IgM represent different antibody classes. The Lymphocyte Subset Panel 4 measures absolute lymphocytes, absolute and percentage CD4+ and CD8+ cells, and the CD4/CD8 ratio. Those results describe the makeup of selected lymphocyte populations, not antibody levels. Immune Cell Function reports a functional immune-cell measurement, a different question from counting cells or measuring immunoglobulins.

Using results with the right clinical question

An out-of-range immunoglobulin or lymphocyte result does not establish a diagnosis by itself. Recent illness, ongoing health conditions, and the reason testing was ordered all affect what a result means. A CD4/CD8 ratio should be read alongside the absolute CD4+ cells, absolute CD8+ cells, percentages, and absolute lymphocyte count; a ratio alone can obscure whether one count, both counts, or their relationship is driving the result. Natural Killer Cells is appropriate when the question is specifically about that cell type. For symptoms, repeated abnormal findings, or a high-stakes clinical concern, professional review connects laboratory findings with history and other evaluation.

Immune System FAQ

An immune system test measures a defined part of immune biology, not immunity as a single number. The Immunoglobulins Panel, Serum measures IgA, IgG, and IgM antibody proteins. Lymphocyte Subset Panel 4 measures lymphocyte counts, CD4+ and CD8+ cells, their percentages, and the CD4/CD8 ratio. Other available options focus on immune cell function or natural killer cells.

IgA, IgG, and IgM are three classes of immunoglobulins, or antibody proteins, measured together in the Immunoglobulins Panel, Serum. Their concentrations help describe one aspect of humoral immune activity. A result should be considered as a three-value pattern rather than treating one antibody class as a stand-alone answer, especially when testing follows recurrent infections or another clinical concern.

Lymphocyte Subset Panel 4 counts selected lymphocyte populations, while the Immunoglobulins Panel, Serum measures circulating IgA, IgG, and IgM. Panel 4 reports absolute lymphocytes, absolute and percentage CD4+ and CD8+ cells, plus the CD4/CD8 ratio. The immunoglobulins panel answers an antibody-protein question; Panel 4 answers a cell-population question.

Absolute counts show the number of CD4+ or CD8+ cells in the measured blood volume, while percentages show their share of the lymphocyte population. Either view alone can be misleading when the total absolute lymphocyte count differs from usual. Reading the absolute CD4+ cells, absolute CD8+ cells, percentages, and total lymphocytes together provides a more informative picture of the reported subset distribution.

The CD4/CD8 ratio describes the relationship between CD4+ and CD8+ cells. It is most useful alongside the individual absolute counts and percentages because the same ratio change can reflect different underlying count patterns. Lymphocyte Subset Panel 4 includes the ratio, absolute lymphocytes, and CD4+ and CD8+ results, allowing that relationship to be reviewed with its component measurements.

Immune Cell Function reports a functional immune-cell measurement, whereas a lymphocyte subset panel reports quantities and proportions of specified cells. A count answers how many measured cells are present; a functional result addresses a different laboratory characteristic. These tests are not interchangeable, so the ordering question should identify whether the concern centers on cell numbers or immune-cell function.

Natural Killer Cells focuses on natural killer cells rather than the IgA, IgG, and IgM antibody protein concentrations measured in the Immunoglobulins Panel, Serum. It also differs from Lymphocyte Subset Panel 4, which is identified by CD4+, CD8+, lymphocyte, and ratio measurements. It fits a focused question about natural killer cells instead of a request for those other named measurements.

No, an abnormal result does not diagnose an immune disorder by itself. Immunoglobulin concentrations, lymphocyte counts, CD4/CD8 relationships, natural killer cell findings, and immune cell function each describe limited laboratory information. Results need to be interpreted with symptoms, health history, timing, and other clinical findings. Professional review is particularly important for persistent abnormalities or significant symptoms.

No. Immunofixation (IFE) and Immunoglobulins Panel (IgG, IgA, IgM), Serum includes immunofixation in addition to IgG, IgA, and IgM measurements. The Immunoglobulins Panel, Serum is the direct option for measured IgA, IgG, and IgM concentrations. The added IFE component makes these distinct choices when a clinician’s laboratory question specifically includes immunofixation.

Ordering & Results FAQ

You'll receive it via email within 60 seconds of your order unless it requires additional processing (only very complex orders do).

Many general wellness test results are typically available online within 2-3 business days. However, some tests will require additional processing time. You will immediately receive an email & SMS notification when your results are available.

We do not share your results with your physician, insurance company, or any other third party.