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Celiac disease test for people with digestive issues, gluten sensitivity, and IgA deficiency

Blood Test for Celiac Disease and Gluten Sensitivity

Anti-tTG IgG (Tissue Transglutaminase IgG)

Google
3,138 reviews
  • Supports diagnosis of celiac disease
  • Alternative marker for celiac in IgA deficiency
  • Evaluates potential intestinal damage
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you suspect you have celiac disease but also have IgA deficiency, which can make standard celiac tests unreliable. It's especially useful if you're experiencing digestive issues like bloating, diarrhea, or abdominal pain after eating gluten, along with unexplained weight loss, fatigue, or nutrient deficiencies. Many people use this test when they've had negative IgA-based celiac tests but symptoms persist.

What's included in this test?

This test measures Anti-tissue Transglutaminase IgG antibodies, which are markers your immune system produces when it reacts to gluten in people with celiac disease. It's specifically designed as an alternative screening tool for individuals with IgA deficiency, where standard IgA-based celiac tests would be inaccurate. This antibody measurement helps identify potential intestinal damage caused by gluten consumption and supports accurate celiac disease diagnosis.

What happens after I get my results?

You'll receive detailed doctor notes in simple language explaining what your tissue transglutaminase IgG antibody levels mean for your digestive health and potential celiac disease. These notes include personalized recommendations like whether to eliminate gluten from your diet, what follow-up tests you might need, or when to consult a gastroenterologist. You'll also get the standard lab report and can track your antibody levels over time using our trends feature, which is especially helpful if you're implementing a gluten-free diet.

Who should consider getting this test?
This test is essential for anyone with known or suspected IgA deficiency who needs celiac disease screening, since standard celiac tests rely on IgA antibodies. It's also important for people with persistent digestive symptoms, unexplained anemia, chronic fatigue, or family history of celiac disease. Anyone who has tested negative on IgA-based celiac tests but continues to have symptoms should also consider this alternative marker.
What symptoms indicate I may need this test?
Common symptoms include chronic diarrhea, bloating, gas, and abdominal pain after eating foods containing gluten like bread, pasta, or baked goods. You might also experience unexplained weight loss, persistent fatigue, iron-deficiency anemia, or skin rashes. Some people have foggy thinking, joint pain, or tingling in their hands and feet, which can all be related to celiac disease.
How can I support my digestive health if I have celiac disease?
The primary treatment for celiac disease is following a strict gluten-free diet, avoiding all wheat, barley, and rye products. Focus on naturally gluten-free whole foods like fruits, vegetables, lean meats, fish, eggs, and gluten-free grains like rice and quinoa. Healing your gut may take time, so consider working with a dietitian who specializes in celiac disease to ensure you're getting proper nutrition and avoiding hidden gluten sources in processed foods.
What is tissue transglutaminase and why does it matter?
Tissue transglutaminase (tTG) is an enzyme found throughout your body that helps repair tissue damage. In people with celiac disease, the immune system mistakenly creates antibodies against this enzyme when gluten is present, causing inflammation and damage to the small intestine. Testing for these antibodies (especially IgG when IgA is deficient) helps identify if your immune system is reacting to gluten in this harmful way.
What does a positive Anti-tTG IgG result mean?
A positive result means your immune system is producing IgG antibodies against tissue transglutaminase, which strongly suggests celiac disease, especially in people with IgA deficiency. This indicates your body is reacting to gluten and potentially causing damage to your small intestine. Your doctor will likely recommend additional tests like an endoscopy with biopsy to confirm the diagnosis before starting treatment.
What causes elevated Anti-tTG IgG antibodies?
Elevated Anti-tTG IgG antibodies are primarily caused by celiac disease, an autoimmune condition triggered by eating gluten-containing foods. When people with celiac disease consume gluten, their immune system attacks the small intestine lining and produces these antibodies. In rare cases, other autoimmune conditions or liver disease might cause elevated levels, but celiac disease is the most common cause.
How often should I retest my Anti-tTG IgG levels?
If you're newly diagnosed with celiac disease and have started a gluten-free diet, your doctor may retest after 6-12 months to ensure antibody levels are decreasing. Once your levels normalize and you're maintaining a strict gluten-free diet, annual testing may be recommended to monitor compliance. If you accidentally consume gluten or symptoms return, retesting can help determine if your intestine is being affected again.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Anti-tTG IgG (Tissue Transglutaminase IgG) 8.5 U/mL
Demo results
Negative < 6 Positive ≥ 6
8.5 U/mL

What this means

Your Anti-tTG IgG antibody level is elevated, which suggests your immune system may be reacting to gluten. This is particularly significant if you have IgA deficiency, as this IgG marker serves as a reliable alternative for celiac disease screening. This result warrants follow-up testing and consultation with a gastroenterologist.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
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Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Blood Test for Celiac Disease and Gluten Sensitivity

Google
3,138 reviews
  • Supports diagnosis of celiac disease
  • Alternative marker for celiac in IgA deficiency
  • Evaluates potential intestinal damage

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.