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This test is ideal if you're experiencing unexplained digestive issues like bloating, diarrhea, stomach pain, or weight loss after eating foods with gluten. It helps identify celiac disease, an autoimmune condition where gluten triggers your immune system to attack your small intestine. Many people use this test when they suspect gluten is causing their symptoms but want confirmation before making major dietary changes.
It's crucial to continue eating foods containing gluten before this test, as avoiding gluten can lead to false negative results. Do not start a gluten-free diet until after testing, even if you suspect celiac disease. No fasting is typically required for this test, but check with your testing location for any specific requirements.
This test measures Tissue Transglutaminase (tTG) IgA antibodies, which are the most sensitive and specific markers for celiac disease. When you have celiac disease, your immune system produces these antibodies in response to gluten, and elevated levels strongly suggest an autoimmune reaction damaging your intestinal lining. This test helps determine if your digestive symptoms, nutrient deficiencies, or other health issues are related to gluten intolerance.
What this means
Your tTG IgA antibody level is elevated, which indicates your immune system is producing antibodies in response to gluten. This strongly suggests celiac disease and means gluten may be triggering inflammation and damage to your small intestine. Follow-up with a gastroenterologist is recommended to confirm the diagnosis.
Recommended actions
Continue eating gluten until you complete follow-up testing with a gastroenterologist
Schedule an appointment for endoscopy and biopsy to confirm celiac disease diagnosis
Begin researching gluten-free diet options and consider consulting a dietitian
Retest tTG IgA levels 6-12 months after starting a gluten-free diet to monitor improvement
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