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Gender Reassignment Testing

Gender Reassignment with Thyroids
48 Biomarkers
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Before starting any Hormone Replacement Therapy regimen a baseline of certain laboratory tests are recommended. It is also important to have regular lab testing to ensure the prescribed therapy is working as intended. Transgender Hormone Therapy programs vary by prescriber as well as the recommended lab tests for baseline assessment and monitoring. The lab tests listed on this page are the tests that are most popular with gender reassignment.

Prolactin  (Quest Diagnostics)

Same day lab order delivery

HSA/FSA reimbursable
Both men and women usually have low levels of prolactin. High levels of prolactin, interfere with the man's ability to produce testosterone.

Prolactin is a protein hormone of the anterior lobe of the pituitary gland that induces and maintains lactation in the postpartum women.
During pregnancy and postpartum lactation, serum prolactin can increase 10- to 20-fold. Exercise, stress, and sleep also cause transient increases in prolactin levels. Consistently elevated serum prolactin levels (>30 ng/mL), in the absence of pregnancy and postpartum lactation, are indicative of hyperprolactinemia. Hypersecretion of prolactin can be caused by pituitary adenomas, hypothalamic disease, breast or chest wall stimulation, renal failure or hypothyroidism. A number of drugs, including many antidepressants, are also common causes of abnormally elevated prolactin levels. Hyperprolactinemia often results in galactorrhea, amenorrhea, and infertility in women, and in impotence and hypogonadism in men. Renal failure, hypothyroidism, and prolactin-secreting pituitary adenomas are also common causes of abnormally elevated prolactin levels.

A significant deviation from the normal range may require further evaluation by your physician.
Prolactin, serum
Overnight fasting is preferred. Fasting is defined as no consumption of food or beverage other than water for at least 8 - 10 hours before testing.

Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.

Follicle-stimulating Hormone (FSH) and Luteinizing Hormone (LH)  (Quest Diagnostics)

Same day lab order delivery

HSA/FSA reimbursable
FSH/LH testing is used in the workup of infertility (for both men and women). Used also to investigate low sperm count, menstrual irregularities, pitutary disorders, diseases involving the testes or ovaries. May be used to determine the cause of early or delayed puberty.
FSH and LH are secreted by the anterior pituitary in response to gonadotropin-releasing hormone (GNRH) secreted by the hypothalamus. In both males and females, FSH and LH secretion is regulated by a balance of positive and negative feedback mechanisms involving the hypothalamic-pituitary axis, the reproductive organs, and the pituitary and sex steroid hormones. FSH and LH play a critical role in maintaining the normal function of the male and female reproductive systems. Abnormal FSH levels with corresponding increased or decreased levels of LH, estrogens, progesterone, and testosterone are associated with a number of pathological conditions. Increased FSH levels are associated with menopause and primary ovarian hypofunction in females and primary hypogonadism in males. Decreased levels of FSH are associated with primary ovarian hyper-function in females and primary hypergonadism in males. Normal or decreased levels of FSH are associated with polycystic ovary disease in females. In males, LH is also called interstitial cell-stimulating hormone (ICSH). Abnormal LH levels with corresponding increased or decreased levels of FSH, estrogens, progesterone, and testosterone are associated with a number of pathological conditions. Increased LH levels are associated with menopause, primary ovarian hypofunction, and polycystic ovary disease in females and primary hypo-gonadism in males. Decreased LH levels are associated with primary ovarian hyperfunction in females and primary hyper-gonadism in males.

A significant deviation from the normal range may require further evaluation by your physician.
Follicle-stimulating Hormone (FSH) and Luteinizing Hormone (LH)

No fasting required.

Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.

Women's Hormone Light Test  (Quest Diagnostics)

Same day lab order delivery

HSA/FSA reimbursable

Our Women’s Hormone Light Test is tailored specifically for women seeking optimal well-being. 

This panel includes the essentials: hormones like estradiol, FSH, LH, and total testosterone and wellness biomarkers like CBC and CMP, which can help you gain valuable insights to enhance fertility, regulate menstrual health, boost energy levels, and promote overall vitality. If you want something quick but effective, this panel is for you.

Complete Blood Count / CBC (includes Differential and Platelets): WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet Count, MPV and Differential (Absolute and Percent - Neutrophils, Lymphocytes, Monocytes, Eosinophils, and Basophils)
Comprehensive Metabolic Profile ( includes eGFR ): Albumin, Albumin/Globulin Ratio (calculated), Alkaline Phosphatase, ALT, AST, BUN/Creatinine Ration, Calcium, Carbon Dioxide, Chloride, Creatinine with GFR Estimated, Globulin (calculated), Glucose, Potassium, Sodium, Total Bilirubin, Total Protein, Urea Nitrogen
Estradiol
Follicle-Stimulating Hormone (FSH)
Luteinizing Hormone (LH)
Testosterone Total LC/MS/MS
(This testosterone test will also provide results when the total testosterone value is >1500 but <10,000.)
Patient should fast for 12 hours preceding collection of specimen. If using a testosterone cream please be sure you have not rubbed any into the antecubital area of your arm for the last 24 hours as it can give elevated results. Some tests in this panel may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H or coenzyme R). Patient should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Estimated turnaround for results is 5 business days. If confirmation testing is required, the estimated time may be extended.

Gender Reassignment with Thyroids  (Quest Diagnostics)

Same day lab order delivery

HSA/FSA reimbursable
This panel is designed for base level testing and monitoring for individuals on hormone replacement therapy.


Actual Total Testosterone levels will be provided with this test for levels up to 10,000.

Significant deviations from the normal range may require further evaluation by your physician.
Complete Blood Count / CBC (includes Differential and Platelets): WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet Count, MPV and Differential (Absolute and Percent - Neutrophils, Lymphocytes, Monocytes, Eosinophils, and Basophils)
Comprehensive Metabolic Profile ( includes eGFR ): Albumin, Albumin/Globulin Ratio (calculated), Alkaline Phosphatase, ALT, AST, BUN/Creatinine Ratio (calculated), Calcium, Carbon Dioxide, Chloride, Creatinine with GFR Estimated, Globulin (calculated), Glucose, Potassium, Sodium, Total Bilirubin, Total Protein, Urea Nitrogen
Estrogens (Total), Serum
Lipid Panel: Cholesterol, total; high-density lipoprotein (HDL) cholesterol; low-density lipoprotein (LDL) cholesterol (calculated); triglycerides; Non-HDL Cholesterol (calculated).
Testosterone Total LC/MS/MS
Thyroid Profile w/ TSH:
T3 Uptake; T4 (Thyroxine), Total; Free T4 Index (T7); Thyroid-Stimulating Hormone (TSH)
Patient should fast for 12-14 hours prior to collection of the specimen. If using a testosterone cream please be sure you have not rubbed any into the antecubital area of your arm for the last 24 hours as it can give elevated results.

Estimated turnaround for results is 7 business days. If confirmation testing is required, the estimated time may be extended.

Prolactin  (LabCorp)

Same day lab order delivery

HSA/FSA reimbursable
Both men and women usually have low levels of prolactin. High levels of prolactin, interfere with the man's ability to produce testosterone.

Prolactin is a protein hormone of the anterior lobe of the pituitary gland that induces and maintains lactation in the postpartum women.
During pregnancy and postpartum lactation, serum prolactin can increase 10- to 20-fold. Exercise, stress, and sleep also cause transient increases in prolactin levels. Consistently elevated serum prolactin levels (>30 ng/mL), in the absence of pregnancy and postpartum lactation, are indicative of hyperprolactinemia. Hypersecretion of prolactin can be caused by pituitary adenomas, hypothalamic disease, breast or chest wall stimulation, renal failure or hypothyroidism. A number of drugs, including many antidepressants, are also common causes of abnormally elevated prolactin levels. Hyperprolactinemia often results in galactorrhea, amenorrhea, and infertility in women, and in impotence and hypogonadism in men. Renal failure, hypothyroidism, and prolactin-secreting pituitary adenomas are also common causes of abnormally elevated prolactin levels.

A significant deviation from the normal range may require further evaluation by your physician.
Prolactin, serum

No fasting required.

Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.

Follicle-stimulating Hormone (FSH) and Luteinizing Hormone (LH)  (LabCorp)

Same day lab order delivery

HSA/FSA reimbursable
FSH/LH testing is used in the workup of infertility (for both men and women). Used also to investigate low sperm count, menstrual irregularities, pitutary disorders, diseases involving the testes or ovaries. May be used to determine the cause of early or delayed puberty.
Follicle-stimulating Hormone (FSH) and Luteinizing Hormone (LH)

No fasting required.

Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.

Gender Reassignment  (LabCorp)

Same day lab order delivery

HSA/FSA reimbursable
This panel is designed for base level testing and monitoring for individuals on hormone replacement therapy.

Use of synthetic steroids, various supplements and/or high doses of biotin may interfere with the accuracy of the standard immunoassay Testosterone Total serum test included in this panel. If you are taking any of these it is recommended that you order a panel that includes the Testosterone LC/MS-MS methodology for testing.

Significant deviations from the normal range may require further evaluation by your physician.
Complete Blood Count (CBC) w/ Differential: Hematocrit; hemoglobin; mean corpuscular volume (MCV); mean corpuscular hemoglobin (MCH); mean corpuscular hemoglobin concentration (MCHC); red cell distribution width (RDW); percentage and absolute differential counts; platelet count; red cell count; white blood cell count; immature granulocytes.
Comprehensive Metabolic Profile ( includes eGFR ): A:G ratio; albumin, serum; alkaline phosphatase, serum; ALT (SGPT); AST (SGOT); bilirubin, total; BUN; BUN:creatinine ratio; calcium, serum; carbon dioxide, total; chloride, serum; creatinine, serum; globulin, total; glucose, serum; potassium, serum; protein, total, serum; sodium, serum; eGFR.
Estrogens (Total), Serum
Lipid Profile:
Cholesterol, total; high-density lipoprotein (HDL) cholesterol; low-density lipoprotein (LDL) cholesterol (calculation); triglycerides; very low-density lipoprotein (VLDL) cholesterol (calculation).
Testosterone, Total, Serum

Note: If testosterone levels are expected to be >1500, it is best that you order a panel that includes Testosterone LC/MS-MS as the testosterone test included in this panel has a cutoff of 1500. Reporting values that exceed 1500 will now be reported as >1500 for all regions, as this standard operating procedure will now be nationwide.
Patient should fast for 12-14 hours preceding collection of specimen. If using a testosterone cream please be sure you have not rubbed any into the antecubital area of your arm for the last 24 hours as it can give elevated results. This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H or coenzyme R). It is recommended to stop biotin consumption at least 72 hours prior to the collection of specimen.

Estimated turnaround for results is 5 business days. If confirmation testing is required, the estimated time may be extended.

Gender Reassignment with Thyroid  (LabCorp)

Same day lab order delivery

HSA/FSA reimbursable
This panel is designed for base level testing and monitoring for individuals on hormone replacement therapy.

Use of synthetic steroids, various supplements and/or high doses of biotin may interfere with the accuracy of the standard immunoassay Testosterone Total serum test included in this panel. If you are taking any of these it is recommended that you order a panel that includes the Testosterone LC/MS-MS methodology for testing.

Significant deviations from the normal range may require further evaluation by your physician.
Complete Blood Count (CBC) w/ Differential: Hematocrit; hemoglobin; mean corpuscular volume (MCV); mean corpuscular hemoglobin (MCH); mean corpuscular hemoglobin concentration (MCHC); red cell distribution width (RDW); percentage and absolute differential counts; platelet count; red cell count; white blood cell count; immature granulocytes.
Comprehensive Metabolic Profile ( includes eGFR ): A:G ratio; albumin, serum; alkaline phosphatase, serum; ALT (SGPT); AST (SGOT); bilirubin, total; BUN; BUN:creatinine ratio; calcium, serum; carbon dioxide, total; chloride, serum; creatinine, serum; globulin, total; glucose, serum; potassium, serum; protein, total, serum; sodium, serum; eGFR.
Estrogens (Total), Serum
Lipid Profile:
Cholesterol, total; high-density lipoprotein (HDL) cholesterol; low-density lipoprotein (LDL) cholesterol (calculation); triglycerides; very low-density lipoprotein (VLDL) cholesterol (calculation).
Testosterone, Total, Serum
Thyroid Profile w/ TSH:
Free thyroxine index; T3 uptake (THBR); thyroid-stimulating hormone (TSH); thyroxine (T4)

Note: If testosterone levels are expected to be >1500, it is best that you order a panel that includes Testosterone LC/MS-MS as the testosterone test included in this panel has a cutoff of 1500. Reporting values that exceed 1500 will now be reported as >1500 for all regions, as this standard operating procedure will now be nationwide.
Patient should fast for 12-14 hours preceding collection of specimen. This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H or coenzyme R). It is recommended to stop biotin consumption at least 72 hours prior to the collection of specimen. If using a testosterone cream please be sure you have not rubbed any into the antecubital area of your arm for the last 24 hours as it can give elevated results.

Estimated turnaround for results is 5 business days. If confirmation testing is required, the estimated time may be extended.

Hormone Panel for Females  (LabCorp)

Same day lab order delivery

HSA/FSA reimbursable
***Both MALES and FEMALES order the Hormone Panel for Females from LabCorp, please be sure to enter the gender that you want reference ranges for when placing your order, as each gender has different reference ranges for these tests. ***
Menopause is the time in a woman's life when menstruation stops permanently. Most women go through menopause between ages 45 and 55. In the US the average age for menstrual periods to stop completely is 51.

This panel will help diagnose the onset of menopause.

Use of synthetic steroids, various supplements and/or high doses of biotin may interfere with the accuracy of the standard immunoassay Testosterone Total serum test included in this panel. If you are taking any of these it is recommended that you order a panel that includes the Testosterone LC/MS-MS methodology for testing.

Significant deviations from the normal range may require further evaluation by your physician.
Estradiol, serum;
Follicle-Stimulating Hormone (FSH);
Luteinizing Hormone (LH);
Testosterone, Serum (Total Only);

Complete Blood Count (CBC) with Differential: (Hematocrit; hemoglobin; mean corpuscular volume (MCV); mean corpuscular hemoglobin (MCH); mean corpuscular hemoglobin concentration (MCHC); red cell distribution width (RDW); percentage and absolute differential counts; platelet count; red cell count; white blood cell count; immature granulocytes)
Comprehensive Metabolic Profile (CMP) (includes eGFR): (A:G ratio; albumin, serum; alkaline phosphatase, serum; ALT (SGPT); AST (SGOT); bilirubin, total; BUN; BUN:creatinine ratio; calcium, serum; carbon dioxide, total; chloride, serum; creatinine, serum; globulin, total; glucose, serum; potassium, serum; protein, total, serum; sodium, serum.)

Note: If total testosterone results are expected to be >1500 it is best that the LC/MS-MS version of this panel be ordered. Reporting values that exceed 1500 will now be reported as >1500 for all regions, as this standard operating procedure will now be nationwide.
Patient should fast for 12 hours preceding collection of specimen. If using a testosterone cream please be sure you have not rubbed any into the antecubital area of your arm for the last 24 hours as it can give elevated results. This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H or coenzyme R). It is recommended to stop biotin consumption at least 72 hours prior to the collection of specimen.

Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.

Hormone Panel with Lipids  (LabCorp)

Same day lab order delivery

HSA/FSA reimbursable
Our Hormone Panel for females with the addition of a Lipid Profile.
***Both MALES and FEMALES order this panel, please be sure to enter the gender that you want reference ranges for when placing your order, as each gender has different reference ranges for these tests. ***

Use of synthetic steroids, various supplements and/or high doses of biotin may interfere with the accuracy of the standard immunoassay Testosterone Total serum test included in this panel. If you are taking any of these it is recommended that you order a panel that includes the Testosterone LC/MS-MS methodology for testing.

Significant deviations from the normal range may require further evaluation by your physician.
Estradiol, serum;
Follicle-Stimulating Hormone (FSH);
Luteinizing Hormone (LH);
Testosterone, Serum (Total Only);

Complete Blood Count (CBC) with Differential: (Hematocrit; hemoglobin; mean corpuscular volume (MCV); mean corpuscular hemoglobin (MCH); mean corpuscular hemoglobin concentration (MCHC); red cell distribution width (RDW); percentage and absolute differential counts; platelet count; red cell count; white blood cell count; immature granulocytes)
Comprehensive Metabolic Profile (CMP) (includes eGFR): (A:G ratio; albumin, serum; alkaline phosphatase, serum; ALT (SGPT); AST (SGOT); bilirubin, total; BUN; BUN:creatinine ratio; calcium, serum; carbon dioxide, total; chloride, serum; creatinine, serum; globulin, total; glucose, serum; potassium, serum; protein, total, serum; sodium, serum.)
Lipid Profile: Cholesterol, total; high-density lipoprotein (HDL) cholesterol; low-density lipoprotein (LDL) cholesterol (calculation); triglycerides; very low-density lipoprotein (VLDL) cholesterol (calculation).

Note: If testosterone levels are expected to be >1500, it is best that you order a panel that includes Testosterone LC/MS-MS as the testosterone test included in this panel has a cutoff of 1500. Reporting values that exceed 1500 will now be reported as >1500 for all regions, as this standard operating procedure will now be nationwide.
Patient should fast for 12-14 hours preceding collection of specimen. If using a testosterone cream please be sure you have not rubbed any into the antecubital area of your arm for the last 24 hours as it can give elevated results. This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H or coenzyme R). It is recommended to stop biotin consumption at least 72 hours prior to the collection of specimen.

Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.

FAQ

  1. What is gender reassignment testing?

    Gender reassignment testing is a medical test that evaluates and monitors hormone therapy and surgery. Usually, they are done to analyze transgender people’s gender reassignment procedures, which entail modifications of their physiology and physical appearance.

  2. What is the purpose of gender reassignment testing?

    The primary purpose of gender reassignment testing is to monitor an individual’s hormone levels and physical characteristics to ensure they are consistent with their gender identity or ready to start their therapy journey. It's a way to:

    • Evaluate the efficacy and safety of hormonal treatment
    • Decide on necessary modifications
    • Check that the transgender individual is healthy enough to start gender reassignment therapy
  3. What is some of the testing that a transgender person must go through?

    The best treatment protocol usually starts with an evaluation of the patient’s genetics, a history of family members, as well as a screening of their general health and any history of illness. Also, it is advised to perform blood tests for hormone levels, lipid profiles, CMP (comprehensive metabolic panel) and CBC (complete blood count).

  4. How effective is gender reassignment therapy?

    There is no definitive answer to how effective gender reassignment therapy is, as success rates depend on:

    • The individual's specific goals and objectives
    • The type of gender reassignment therapy used
    • The individual's physiological reaction to the treatment and procedures

    That being said, getting regular testing will allow you to get a more effective and safe treatment in the long run.

  5. Do I need to visit a doctor?

    Nope. You don't need a doctor's visit to get a test with us.

  6. How do I get my results?

    You'll get your results via email as soon as they are available. We will notify you via SMS as well. You can also see them at any time in the future right in your dashboard where you can easily share them with your professional and compare them side by side with future tests.

  7. Does my lab prescription expire?

    We're the only lab that honors your lab order forever.

Questions about online blood testing or how to order a lab test?

Speak with our Wellness Team: (877) 283-7882
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