Call us: 1.877.283.7882 | Monday–Friday: 8:00 AM–4:30 PM ET

Private MD News

Home | News | Allergy Testing

New clues to how corticosteroids help treat allergies

Category: Allergy Testing

Research coming out of the Imperial College in London may provide an explanation for why corticosteroids are effective treatments for allergic inflammation. This in turn may point the way to new targets for treating allergic diseases in the future.

The roughly 50 million people in the U.S. affected by allergic diseases share an extreme reaction by the immune system to a normally harmless bit of material. The cascade starts when the immune system activates a specific cell type called a T helper-2 cell (Th2), causing it to make three cytokines which in turn are responsible for the inflammation associated with an allergic response. Corticosteroids are used to treat this inflammation, but it has not been well understood how they inhibit the Th2 cytokines.

After testing people with mild asthma, lead researcher Peter Barnes suggests in the study that the corticosteroids inhibit the expression of Th2 cytokines by preventing GATA-3, a key regulator of cytokine expression, from being properly phosphorylated or transported into the nucleus by a protein called importin-a.

The authors say that these findings suggest GATA-3 and importin-a could be useful targets for future therapies for allergic disease.ADNFCR-2248-ID-19192183-ADNFCR

Related Articles from Private MD:

Share on Facebook

Subscribe to Private MD Health News RSS Feed: Subscribe

News Categories:

Advanced Lipid Treatment I   Allergy Testing   Anemia and RBC disorders   Autoimmune Diseases   Bariatric Lab Testing   Blood and Blood Diseases   Breast   Cancer Detection and Tumor Markers   Celiac Disease Testing   Chlamydia   Coagulation and blood clotting disorders   Colon   Diabetes   DNA, Paternity and Genetic testing   Drug Screening   Environmental Toxin Testing   Female Specific Tests   Gastrointestinal Diseases   General Health   General Wellness   Heart Health and Cholesterol   Herpes   HIV   HIV monitoring/Treatment/Testing/Post Diagnos   Hormones and Metabolism   Infectious Diseases   Infertility Testing-Male   Infertitlity Hormone Testing   Kidney Diseases   Leukemia and WBC disorders   Liver   Liver Diseases   Lyme Disease   Male Specific Tests   Menopause/Peri-Menopausal Diagnosis   Musculoskeletal Diseases   Organ Specific Testing   Ovarian   Prostate   Sexually Transmitted Diseases   Thyroid Diseases   Transgender Hormone Testing-female to male   Transgender Hormone Testing-Male to Female   Vitamin D Deficiency-Diagnosis and Treatment   

Visit the Health News Archive: Click Here

Questions about online blood testing or how to order a lab test? Click here to get started or call us toll-free at 1.877.283.7882. Our professionals are ready to assist you.

Back to top