Call us: 1.877.283.7882 | Monday–Friday: 8:00 AM–4:30 PM ET

Private MD News

Home | News | Heart Health and Cholesterol

Newly-identified enzyme may control bad cholesterol

Category: Heart Health and Cholesterol

UCLA scientists have discovered a new mechanism that controls the way cells produce low-density lipoprotein (LDL), the so-called "bad" cholesterol linked to serious cardiovascular problems and stroke. Working with mice, the researchers identified an enzyme called Idol which destroys the receptor responsible for clearing LDL cholesterol from the bloodstream.

"We only know of three pathways that regulate the LDL receptor. The first two are already targeted by existing drugs," said principal investigator Dr Peter Tontonoz, a professor of pathology and laboratory medicine at the David Geffen School of Medicine at UCLA and a Howard Hughes Medical Institute investigator. "Idol is the first mechanism discovered in several years that may lead to a new medication designed to control cholesterol levels."

Statin drugs, the most commonly prescribed approach for lowering LDL cholesterol, work by increasing the amount of the receptor. The UCLA team hopes that by inactivating Idol, they could prevent destruction of the receptor, thus attacking the problem from another angle. This would be especially helpful for people who do not tolerate the side effects of statins well.

The American Heart Association considers an LDL level of 160 mg/dL as too high. Cholesterol can be assessed with a simple blood test.ADNFCR-2248-ID-19219926-ADNFCR

Related Articles from Private MD:

Share on Facebook

Subscribe to Private MD Health News RSS Feed: Subscribe

News Categories:

Advanced Lipid Treatment I   Allergy Testing   Anemia and RBC disorders   Autoimmune Diseases   Bariatric Lab Testing   Blood and Blood Diseases   Breast   Cancer Detection and Tumor Markers   Celiac Disease Testing   Chlamydia   Coagulation and blood clotting disorders   Colon   Diabetes   DNA, Paternity and Genetic testing   Drug Screening   Environmental Toxin Testing   Female Specific Tests   Gastrointestinal Diseases   General Health   General Wellness   Heart Health and Cholesterol   Herpes   HIV   HIV monitoring/Treatment/Testing/Post Diagnos   Hormones and Metabolism   Infectious Diseases   Infertility Testing-Male   Infertitlity Hormone Testing   Kidney Diseases   Leukemia and WBC disorders   Liver   Liver Diseases   Lyme Disease   Male Specific Tests   Menopause/Peri-Menopausal Diagnosis   Musculoskeletal Diseases   Organ Specific Testing   Ovarian   Prostate   Sexually Transmitted Diseases   Thyroid Diseases   Transgender Hormone Testing-female to male   Transgender Hormone Testing-Male to Female   Vitamin D Deficiency-Diagnosis and Treatment   

Visit the Health News Archive: Click Here

Questions about online blood testing or how to order a lab test? Click here to get started or call us toll-free at 1.877.283.7882. Our professionals are ready to assist you.

Back to top