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Genetic clotting test for people with family history of blood clots

Inherited Thrombophilia Genetic Test — Blood Clot Risk

Thrombophilia Screen II, Inherited

  • Screen for inherited blood clot risk
  • Detect Factor V Leiden gene changes
  • Assess family history clotting risk
$5073
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
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Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay
  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

What's this test for?

This test is ideal if you're experiencing unexplained blood clots, have had a deep vein thrombosis or pulmonary embolism, or have close family members who developed blood clots at a young age. It looks for inherited genetic changes that make your blood more likely to clot abnormally. It's also useful if you've had multiple miscarriages, since certain clotting gene changes have been linked to pregnancy loss.

What's included in this test?

This screen checks for inherited DNA changes that are strongly linked to abnormal blood clotting, which matters because carrying these variants can raise your lifetime risk of dangerous clots like DVT or pulmonary embolism. Knowing your genetic status helps explain unexplained clotting events and informs precautions around surgery, pregnancy, hormone use, and travel.

What happens after I get my results?

Your results will show up in your account along with an explanation of what a positive or negative finding means. If a genetic variant is found, next steps usually include discussing safe activity levels, being aware of situations that raise clotting risk like long flights or surgery, and letting family members know they may want to get tested too. You can download a standard lab report from your account any time, and since this is a one-time genetic result, tracking over time isn't typically needed for this specific test. If you ever notice sudden leg swelling, chest pain, or shortness of breath, seek medical care right away.

How can I naturally support healthy blood flow?
Staying active, moving your legs during long trips, and maintaining a healthy weight all help support healthy circulation. Drinking enough water and avoiding long periods of sitting can also lower clotting risk. Limiting smoking and excess alcohol supports overall vascular health as well, though these steps don't replace medical precautions if you carry a clotting gene variant.
When will I get my results?
Results are typically ready within about 7 days of your sample being processed at the lab. Genetic tests like this one can take a bit longer than standard bloodwork because of the specialized DNA analysis involved. You'll be notified as soon as your results are available in your account.
Who should consider this test?
This test is a good fit for people who've had an unexplained blood clot, especially at a younger age, or who have a parent or sibling with a known clotting disorder. It's also worth considering before starting hormone therapy or birth control if there's a family history of clots, or if you've had repeated pregnancy losses. People preparing for major surgery with a family history of clotting issues may also want this information ahead of time.
What symptoms indicate I may need this test?
Leg swelling, pain, warmth, or redness (especially in one leg) can be signs of a blood clot and worth investigating. Sudden shortness of breath or chest pain can signal a clot has traveled to the lungs, which is a medical emergency. Recurrent miscarriages or a strong family history of clotting problems are also good reasons to consider this screen.
What is Factor V Leiden and why does it matter?
Factor V Leiden is a common genetic change that affects a protein involved in blood clotting, making clots more likely to form and less likely to break down normally. People who carry one copy have a moderately increased risk of clots, while those with two copies have a much higher risk. It matters because knowing you carry this variant can guide decisions about medications, pregnancy planning, and precautions during travel or surgery.
What does a positive result mean?
A positive result means you carry one or more copies of a genetic variant linked to higher blood clotting risk, such as Factor V Leiden or the HR2 allele. This doesn't mean you will definitely develop a clot, but it does mean your risk is higher than average, especially when combined with other risk factors like surgery, pregnancy, or hormone therapy. Practical steps include staying active, avoiding prolonged immobility, and being extra alert to clot symptoms during high-risk periods.
What should I do if my results are positive?
If your results show a clotting gene variant, it's smart to mention this before any planned surgery, long-haul travel, or before starting estrogen-containing medications. Share the result with close blood relatives, since they may carry the same variant and benefit from knowing. Keep the lab report on hand for future reference, and watch for warning signs like leg swelling or sudden breathing trouble, seeking emergency care if they occur.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Factor V Leiden (R506Q) Mutation Negative
Demo results
Negative (Normal) Positive (Variant Detected)
Negative

What this means

A negative result means the Factor V Leiden gene variant was not detected, so this particular inherited clotting risk is not present. This lowers the likelihood that your clotting risk is genetically elevated, though other risk factors can still contribute to clot formation.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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Search Quest Diagnostics and LabCorp locations available through Private MD Labs.

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Inherited Thrombophilia Genetic Test — Blood Clot Risk

  • Screen for inherited blood clot risk
  • Detect Factor V Leiden gene changes
  • Assess family history clotting risk
$5073
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.