What's this test for?

This test is ideal if you're experiencing a suspicious skin lesion, ulcer, or tissue growth and need to know if it's caused by the bacteria that causes syphilis. It's typically used when a piece of tissue has already been removed and preserved (FFPE) for pathology review, and there's a concern that a hard-to-diagnose sore or rash could be syphilis rather than another skin condition. This test helps confirm or rule out that specific cause so you can get a clear answer.

What's included in this test?

This test uses a special staining technique called immunohistochemistry (IHC) on tissue that's already been preserved, looking specifically for the presence of T. pallidum, the bacteria responsible for syphilis. This method matters because it can detect the bacteria directly in the tissue sample even when routine blood antibody tests are unclear or when a skin biopsy needs a definitive answer.

What happens after I get my results?

Your results will show up in your online account along with a clear explanation of what a positive or negative finding means for this specific test. If the result comes back positive, the report will outline simple next steps, such as retesting or additional evaluation of the affected tissue; if it's negative and your lesion isn't healing, that's a sign to look into other causes. You can download the full lab report from your account at any time, and if you've had related testing before, you can track results over time using the trends feature.

How can I naturally support healing while I wait for tissue test results?

While you wait, keep the area clean and dry, avoid picking at or irritating the lesion, and don't apply harsh over-the-counter products that could interfere with healing or further irritate the skin. Eating a balanced diet with enough protein, vitamin C, and zinc can support your body's natural tissue repair process. Avoid sexual contact with the affected area until you have a clear result, since syphilis is contagious during active lesions.

When will I get my results?

Results for this specialized tissue test typically take about 7 days because the sample undergoes detailed lab processing and staining before a pathologist can interpret it. You'll see your results posted directly in your online account as soon as they're finalized, so there's no need to call or wait on hold for an update.

Who should consider this test?

This test is a good fit for anyone with an existing tissue sample (biopsy) from a suspicious sore, ulcer, or skin lesion where syphilis is a possible cause. It's especially useful when standard blood tests haven't given a clear answer, or when a pathologist needs to confirm the specific organism present in the tissue.

What symptoms indicate I may need this test?

Watch for a firm, round, and usually painless sore (called a chancre) on the skin or genitals, unexplained skin rashes, or lesions that aren't healing as expected. Swollen lymph nodes near the sore and a history of unprotected sexual contact are also reasons to consider this kind of testing. If a piece of tissue has already been biopsied for these symptoms, this test can help identify the exact cause.

What does a positive result mean?

A positive result means the test detected T. pallidum bacteria directly in your tissue sample, confirming that syphilis is present in that area. This is considered a clear, direct finding, and it means treatment for syphilis should be started as soon as possible to prevent the infection from progressing to later stages.

What causes syphilis and how is it spread?

Syphilis is caused by the bacteria T. pallidum and spreads mainly through direct contact with a syphilis sore during vaginal, anal, or oral sex. It can also pass from a pregnant person to their baby. Sores can be hidden inside the body, so someone can transmit it without knowing they're infected.

What should I do if my results are abnormal?

If your result is positive, treatment with antibiotics is typically very effective, especially when started early, so don't delay in seeking care. Let recent sexual partners know so they can get tested too, and avoid sexual contact until you and any partners have been treated and cleared. Retesting after treatment is often recommended to confirm the infection has cleared.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Syphilis IHC Tissue Test - Skin Lesion Diagnosis

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]