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Pap and HPV mRNA test for women checking cervical cell and HPV changes

Pap Smear and HPV Test with Genotype 16, 18/45 Screening

SurePath™ Pap and HPV mRNA E6/E7 Reflex Genotypes 16, 18/45

  • Screen for cervical cell changes
  • Detect high-risk HPV infections
  • Monitor long-term cervical health risks
$814
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay
  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

What's this test for?

This test is ideal if you're due for cervical cancer screening or if you want to check for high-risk HPV strains that can lead to cervical changes over time. It combines a Pap smear with an HPV mRNA test, which looks for signs that the virus is actively causing cell changes rather than just being present. It's a good option if you've had an abnormal Pap in the past or simply want peace of mind about your cervical health.

What happens after I get my results?

Your results will show up in your account with a clear explanation of what each part of the test means, including whether your Pap findings were normal and whether HPV mRNA was detected. If HPV 16 or 18/45 genotypes are found, the report will explain what that means and suggest a reasonable retesting timeline. You can download a standard lab report anytime, and if you test again in the future you'll be able to track any changes over time using the trends feature. If results show any concerning findings, the report will note when sooner follow-up testing makes sense.

Who should consider this test?

Women who are due for routine cervical cancer screening, especially those age 25 and older, are good candidates for this test. It's also useful if you've had an abnormal Pap smear before, have a history of HPV, or want a more detailed screening than a Pap alone provides. Anyone who wants to combine cell screening with genotype-specific HPV detection in one visit will benefit from this combined approach.

What symptoms indicate I may need this test?
Most women with early HPV infection or cervical cell changes have no symptoms at all, which is why routine screening matters. That said, unusual vaginal bleeding, bleeding after intercourse, unusual discharge, or pelvic pain can sometimes be signs worth checking out with this kind of test. Even without symptoms, routine screening on a regular schedule is the main reason people order this test.
How can I naturally support cervical health?
Quitting smoking is one of the most effective steps, since smoking is linked to a higher risk of HPV persisting and causing cell changes. Eating a diet rich in fruits, vegetables, and antioxidants supports your immune system's ability to clear HPV naturally. Staying up to date on the HPV vaccine if you're eligible, practicing safer sex, and keeping regular screening appointments all help support long-term cervical health.
When will I get my results?
Results are typically ready within about 7 days of your lab visit. You'll get a notification once they're posted to your account, where you can view the full report and download it as needed.
What does it mean if HPV mRNA is detected?
A detected result means the test found genetic activity from a high-risk HPV type that could potentially lead to cervical cell changes if it doesn't clear on its own. This doesn't mean you have cancer — many HPV infections clear naturally within one to two years thanks to your immune system. Your report will note whether genotype 16 or 18/45 was specifically identified, since these are linked to a higher risk of cervical changes and often call for closer follow-up screening.
What causes an abnormal Pap or positive HPV result?
An abnormal Pap usually means some cervical cells look different than expected, often due to an HPV infection causing mild to moderate changes. HPV itself spreads through skin-to-skin sexual contact and is extremely common — most sexually active people are exposed to it at some point. Factors like smoking, a weakened immune system, or having multiple sexual partners can make it more likely that HPV persists instead of clearing on its own.
How often should I retest?
Retesting frequency depends on your prior results and age, but many women repeat Pap and HPV co-testing every 3 to 5 years if results are normal. If HPV was detected or your Pap showed cell changes, sooner follow-up testing — often within 6 to 12 months — is generally recommended. Your results report will include guidance on a reasonable interval based on your specific findings.
What should I do if my results are abnormal?
Start by reading through the explanation in your results report, which will clarify whether the finding is low-risk or needs closer attention. Many mild abnormalities resolve on their own, so a common next step is simply repeating testing on the recommended timeline. If your results show higher-risk HPV genotypes or more significant cell changes, consider scheduling further evaluation such as a colposcopy sooner rather than later, and seek prompt medical care if you notice unusual bleeding or pain in the meantime.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
HPV mRNA E6/E7 (High-Risk Genotypes 16, 18/45) Not Detected
Demo results
Not Detected Detected
Not Detected

What this means

A 'Not Detected' result means no high-risk HPV genetic activity was found in your sample, which is a reassuring sign for cervical health. This suggests a low likelihood of active HPV-related cell changes at this time.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Find a lab near you

Search Quest Diagnostics and LabCorp locations available through Private MD Labs.

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Pap Smear and HPV Test with Genotype 16, 18/45 Screening

  • Screen for cervical cell changes
  • Detect high-risk HPV infections
  • Monitor long-term cervical health risks
$814
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.