What's this test for?

This test is ideal if you're experiencing joint pain, unexplained fatigue, skin rashes, or muscle weakness that won't go away. These symptoms can sometimes point to an autoimmune condition like lupus or a related connective tissue disorder. Checking for Sm and Sm/RNP antibodies can help you understand whether an autoimmune process might be behind what you're feeling.

What's included in this test?

This test measures two related but distinct antibodies that are both linked to autoimmune activity. Sm antibodies are very specific to lupus, meaning a positive result is a strong signal, while RNP antibodies are more common and appear in several other autoimmune conditions, so looking at both together gives a fuller picture of what might be going on.

What happens after I get my results?

Your results will show up in your online account, with each antibody level explained alongside its normal range so you know exactly what you're looking at. If your levels are elevated, a reasonable next step is tracking your symptoms and considering retesting to see if levels change over time, while very high or rapidly worsening symptoms warrant seeking medical care right away. You can download a standard lab report straight from your account for your records. The trends feature also lets you compare this result to any future tests, so you can watch for patterns over time.

How can I naturally support immune system balance?

While no lifestyle change can eliminate autoimmune antibodies, some habits can help calm overall inflammation and support your immune system. Getting consistent sleep, managing stress through activities like walking or meditation, eating an anti-inflammatory diet rich in vegetables and omega-3s, and avoiding excess sun exposure (which can trigger lupus flares) are all reasonable steps. These habits won't replace medical care if you have an active autoimmune condition, but they can support your overall wellbeing.

When will I get my results?

Lab results for this test are typically ready within about 7 days of your sample being processed. Once ready, they'll be posted directly to your online account where you can view and download them anytime.

Who should consider this test?

People with ongoing joint pain, skin rashes (especially a butterfly-shaped rash on the face), unexplained fatigue, or muscle weakness may want to consider this test. It's also useful for anyone with a family history of lupus or another autoimmune condition, or for people already being monitored for a connective tissue disorder who want to track their antibody levels.

What symptoms indicate I may need this test?

Common symptoms linked to lupus and related autoimmune conditions include joint pain and swelling, persistent fatigue, unexplained fevers, a facial rash, hair loss, and sensitivity to sunlight. Muscle weakness, dry eyes or mouth, and Raynaud's-type color changes in the fingers can also be signs worth checking. If you notice several of these together, it may be worth testing your antibody levels.

What does a high Sm or RNP antibody result mean?

A high Sm antibody result is a strong indicator of lupus, since this antibody is rarely found in other conditions. A high RNP antibody level, especially when much higher than the Sm level, points more toward mixed connective tissue disease or can appear in conditions like Sjögren's syndrome, scleroderma, or polymyositis. In either case, an elevated result is a sign that follow-up testing and symptom tracking are worthwhile.

What causes elevated Sm and RNP antibodies?

These antibodies rise when the immune system mistakenly targets your own cell proteins, which is the hallmark of autoimmune disease. Genetics, hormonal factors, certain infections, and environmental triggers like UV light exposure can all play a role in triggering this immune response. Elevated levels don't have a single cause, but rather reflect an underlying autoimmune process that needs further evaluation.

How often should I retest?

If your results come back normal but symptoms persist, retesting every 6 to 12 months can help catch any changes early. If you've already tested positive, more frequent retesting, such as every few months, can help you and your care team track how your antibody levels are trending alongside your symptoms. Your retesting schedule should ultimately be guided by how your symptoms change over time.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Sm & Sm/RNP Antibody Test - Lupus & Autoimmune Screen

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]