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Prenatal screening test for pregnant women assessing Down syndrome and neural tube defect risk

Serum Integrated Screen Part 2 - Prenatal Down Syndrome Test

Serum Integrated Screen, Part 2

  • Screen for Down Syndrome risk factors
  • Assess neural tube defect risk
  • Track pregnancy health with confidence
$2930
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
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Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay
  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

What's this test for?

This test is ideal if you're pregnant and want to understand your baby's risk for Down Syndrome (Trisomy 21), Trisomy 18, or a neural tube defect. It's the second part of a two-step screening process used routinely during pregnancy to give you and your care team more information early on. Many expecting parents choose this test simply for added peace of mind or to help plan ahead if a risk is identified.

What's included in this test?

This is the second part of an integrated screening approach that combines specific pregnancy hormone and protein markers measured in your blood. These markers matter because their levels, combined with markers from Part 1 and details like gestational age, help estimate the statistical likelihood of certain chromosomal conditions or neural tube defects. Looking at these markers together gives a more accurate picture than any single marker alone.

What happens after I get my results?

Your results will show up in your account with each value explained alongside what's considered a typical range for your stage of pregnancy. If your results show an increased risk, the report will outline what that means and what kind of follow-up testing is typically considered next. You can download a standard lab report directly from your account for your records, and if you complete this screen again in a future pregnancy, you can track and compare results over time using the trends feature. If any result suggests an urgent concern, seek medical care right away.

How can I naturally support a healthy pregnancy while waiting for results?
While this screening itself can't be influenced by lifestyle choices, supporting your overall pregnancy health is always a good idea. Eating a balanced diet with folate-rich foods, staying hydrated, taking your prenatal vitamin consistently, and getting adequate rest all support healthy fetal development. Avoiding alcohol, smoking, and unnecessary medications also helps reduce other pregnancy risks.
When will I get my results?
Results from this screen are typically ready within about 7 days after your sample is collected. Because timing matters for pregnancy screening, it's a good idea to complete testing during the recommended window in your second trimester so results come back while still clinically useful. You'll be notified as soon as your results are available in your account.
Who should consider this test?
This test is generally considered by anyone who is pregnant and wants additional information about chromosomal or neural tube defect risk, especially those who already completed Part 1 of the integrated screen. It's also commonly chosen by those with a family history of genetic conditions, prior affected pregnancies, or by anyone who simply wants more information for peace of mind. It is a standard, widely used part of routine prenatal care.
What symptoms indicate I may need this test?
This isn't a symptom-based test — pregnancy itself and being in the appropriate testing window are the only requirements. There are no physical symptoms that indicate a chromosomal abnormality or neural tube defect, which is exactly why screening exists. If you're currently pregnant and haven't completed this screening yet, that alone is reason enough to consider it.
What does an increased risk result mean?
An increased risk result means the combination of markers suggests a higher-than-average statistical chance of a chromosomal condition or neural tube defect — it is not a diagnosis. Many pregnancies with an increased risk result turn out to be completely unaffected once further testing is done. The report will explain your specific numbers and what additional diagnostic testing options are typically considered next.
How often should I retest?
This screening is designed to be done once per pregnancy during a specific window, so retesting within the same pregnancy generally isn't needed once Part 2 is complete. If you become pregnant again in the future, you would complete the full integrated screen (Part 1 and Part 2) again for that pregnancy. Your trends feature will keep records available if you want to compare across pregnancies.
What should I do if my results are abnormal?
If your results show increased risk, the report will explain recommended next steps, which often include additional diagnostic testing for more definitive answers. Try not to jump to conclusions from screening results alone, since they indicate risk level rather than a confirmed diagnosis. Reach out promptly to schedule any recommended follow-up testing so you can get clarity as soon as possible.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Down Syndrome (Trisomy 21) Risk Screen 1 in 3,500 (Low Risk)
Demo results
Low Risk Increased Risk
1 in 3,500 (Low Risk)

What this means

A low risk result means the combination of markers suggests your baby has a lower-than-cutoff statistical chance of Down Syndrome. This is a screening estimate, not a diagnosis, and most pregnancies with low risk results are unaffected.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
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Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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Serum Integrated Screen Part 2 - Prenatal Down Syndrome Test

  • Screen for Down Syndrome risk factors
  • Assess neural tube defect risk
  • Track pregnancy health with confidence
$2930
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.