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Prenatal screening test for pregnant women assessing Down syndrome and neural tube defect risk

Sequential Integrated Screen Part 1 - Prenatal Risk Test

Sequential Integrated Screen, Part 1

  • Screen for Down Syndrome risk early
  • Assess neural tube defect risk
  • Check Trisomy 18 pregnancy risk
$985
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
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Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay
  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

What's this test for?

This test is ideal if you're pregnant and want to understand your baby's risk for Down Syndrome (Trisomy 21), Trisomy 18, or a neural tube defect. It's a standard part of prenatal care that gives you and your family important information early in pregnancy. Many women choose this test simply for peace of mind or to help plan ahead if a risk is identified.

What's included in this test?

This screening combines blood markers with other pregnancy information to estimate your baby's risk for chromosomal conditions and neural tube defects. It looks at specific proteins and hormones that shift when these conditions are present, helping create a personalized risk score. This is part one of a two-part sequential screen, with part two completing the full risk picture later in pregnancy.

What happens after I get my results?

Your results will appear in your account along with an explanation of what your risk level means compared to the expected range. If your results show an increased risk, the report will outline next steps, which may include additional diagnostic testing to confirm findings. This is part of a two-step screening, so you may need a follow-up blood draw later in pregnancy to complete the full assessment. You can download a standard lab report anytime and track your results over time using the trends feature in your account.

Who should consider this test?
Pregnant women, especially those in their first trimester, who want early information about chromosomal conditions or neural tube defects should consider this test. It's especially useful for women who want to make informed decisions about their pregnancy as early as possible. Women with a family history of genetic conditions or who are of advanced maternal age often find this screening particularly valuable.
What symptoms indicate I may need this test?
This screening isn't based on symptoms — it's a routine part of prenatal care recommended for all pregnant women regardless of how they feel. There are no physical warning signs that indicate a need for this test since it screens for conditions that don't cause maternal symptoms. Your pregnancy timeline, typically the first trimester, is what determines when this test should be done.
How can I naturally support a healthy pregnancy?
While this test itself isn't about lifestyle changes, supporting your pregnancy naturally includes taking a prenatal vitamin with folic acid, eating a balanced diet, staying hydrated, and getting regular light exercise if approved for your pregnancy. Avoiding alcohol, tobacco, and unnecessary medications also helps support a healthy pregnancy. Keeping up with your scheduled prenatal appointments and screenings, like this one, helps you stay informed throughout your pregnancy.
When will I get my results?
Results are typically available within about 7 days of your blood draw. Because this is part of a two-step sequential screen, your complete risk assessment may not be finalized until after your second blood draw later in pregnancy. You'll be notified as soon as your results are ready to view in your account.
What does an increased risk result mean?
An increased risk result means the screening detected patterns in your blood markers that are more commonly seen in pregnancies affected by Down Syndrome, Trisomy 18, or a neural tube defect. This is not a diagnosis — it simply means further testing, such as diagnostic genetic testing, may be recommended to get a clearer answer. Many women with increased risk results go on to have healthy pregnancies after follow-up testing provides more clarity.
How often should I retest?
This test is not repeated within the same pregnancy in the same form — it's part of a two-step sequential screen, so you'll complete part two later in your first or second trimester as instructed. There's no need to retest part one again during the same pregnancy. Each future pregnancy would require its own separate screening.
What should I do if my results are abnormal?
If your results show increased risk, the report will explain recommended next steps, which often include additional diagnostic testing for more definitive answers. Try not to worry — an increased risk result doesn't mean there's definitely a problem, it just flags a pregnancy that may benefit from a closer look. Completing part two of the sequential screen or discussing diagnostic options promptly can help you get clearer information sooner.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Down Syndrome (Trisomy 21) Risk Score 1 in 3,500 (Low Risk)
Demo results
Low Risk Increased Risk
1 in 3,500 (Low Risk)

What this means

A result of 1 in 3,500 means your calculated risk of carrying a baby with Down Syndrome is well below the cutoff used to flag increased risk. This is considered a low-risk, or 'screen negative,' result. Remember this is part one of a two-step screen, so a final combined risk score will come after part two.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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Search Quest Diagnostics and LabCorp locations available through Private MD Labs.

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Sequential Integrated Screen Part 1 - Prenatal Risk Test

  • Screen for Down Syndrome risk early
  • Assess neural tube defect risk
  • Check Trisomy 18 pregnancy risk
$985
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.