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RPR titer test to monitor syphilis treatment response over time

RPR Syphilis Titer Test — Treatment Monitoring

RPR (Monitor) with Reflex to Titer

  • Track syphilis treatment progress over time
  • Monitor titer changes after treatment
  • Detect rising or falling infection activity
$49
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First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you're already diagnosed with syphilis and need to track how well treatment is working. It's also useful if you're following up after past treatment to confirm the infection is resolving. Your care team may recommend repeat testing at 6 to 12 months to watch how your levels change over time.

What happens after I get my results?

Your results will show up in your account along with an explanation of what a reactive or non-reactive result means, and if reactive, a titer value. If your titer is going down compared to a past test, that usually signals treatment is working; if it's rising or staying high, retesting on the same schedule is recommended. You can download a standard lab report anytime from your account, and the trends feature lets you compare titer values across multiple tests to see your progress. If a result seems concerning or you have new symptoms, seek medical care promptly.

What symptoms indicate I may need this test?

You likely don't need new symptoms to get this test if you're already being monitored after a syphilis diagnosis — it's a routine follow-up test, not a screening for new symptoms. That said, if you notice a new rash, sores, swollen lymph nodes, or flu-like symptoms after treatment, it's worth retesting sooner. This test tracks disease activity rather than diagnosing new infections from scratch.

When will I get my results?
Results are typically ready within about 7 days of your blood draw. If your sample comes back reactive, the lab automatically runs a reflex titer, which is included in that same turnaround window, so you don't need to order a separate test. You'll get a notification once everything is ready to view in your account.
Who should consider this test?
This test is meant for people who have already been diagnosed with syphilis and are in the monitoring phase of care, not for first-time screening. It's especially relevant if you finished treatment recently and need to confirm your titer is dropping as expected. People with a history of primary or secondary syphilis are typically advised to retest at 6 to 12 month intervals.
What is RPR titer and why does it matter?
RPR stands for Rapid Plasma Reagin, and it's a blood test that detects markers your body produces in response to syphilis infection. If the initial test is reactive, the lab measures a titer, which is basically a number showing how strong that response is. Watching whether the titer goes up or down over time helps show whether an infection is getting better or getting worse.
What does a rising titer mean?
A titer that goes up compared to your last test, usually described as a fourfold increase, can mean the infection is still active or that reinfection has happened. This isn't something to guess about on your own — it's a signal to get retested using the same lab and test type for an accurate comparison. Keeping consistent testing conditions like this makes it much easier to trust the trend line.
What does a falling titer mean?
A titer that drops, especially by fourfold or more, is generally a good sign that treatment is working and the infection is responding as expected. Many people see titers decline steadily over months following treatment, eventually becoming non-reactive. Sticking to the recommended 6 to 12 month retesting schedule helps you and confirm this pattern clearly.
What causes a false positive on this test?
Because this test looks for a general immune response rather than syphilis-specific antibodies, other conditions can sometimes trigger a reactive result. Things like autoimmune disease, certain infections, cancer, pregnancy, or even just older age have all been linked to false positives. If your result doesn't match your symptoms or history, further testing can help clarify the picture.
How often should I retest?
For primary and secondary syphilis, retesting every 6 to 12 months is the standard approach for monitoring treatment response. It's important to use the same type of test and, ideally, the same lab each time so your titer values can be compared accurately. Sticking to a consistent schedule makes trends in your results much more meaningful.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
RPR (Rapid Plasma Reagin) Titer Reactive, 1:4
Demo results
Non-Reactive Reactive
Reactive, 1:4

What this means

A reactive result with a 1:4 titer means the test detected an immune response consistent with syphilis activity. Comparing this titer to previous results helps show whether the infection is responding to treatment or still active.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
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Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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RPR Syphilis Titer Test — Treatment Monitoring

  • Track syphilis treatment progress over time
  • Monitor titer changes after treatment
  • Detect rising or falling infection activity
$49
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.