What's this test for?

This test is ideal if you're experiencing thyroid symptoms that don't match your lab results, like a fast heart rate, trouble concentrating, or unexplained weight changes, despite normal-looking thyroid hormone levels. It helps if you have a family history of thyroid hormone resistance or a relative already diagnosed with a THRB gene variant. It's also useful if standard thyroid treatment hasn't worked as expected and a genetic cause is suspected.

What happens after I get my results?

Your results will be available in your account, with an explanation of what a positive or negative finding means for the THRB gene. If a variant is found, next steps typically include sharing the pattern of inheritance with family members who may want to test as well, since RTH can run in families. The full lab report is downloadable from your account at any time, and if you retest in the future, you can track your results over time using the trends feature. Because this is a one-time genetic result rather than a fluctuating value, retesting is generally not needed unless a lab confirms an unclear result.

What symptoms indicate I may need this test?

Signs that may point to thyroid hormone resistance include a racing heart, trouble focusing or hyperactivity, poor growth in children, or thyroid hormone levels that look elevated on labs but don't match how you feel. Some people also notice their symptoms don't improve with typical thyroid medication doses. If several family members have similar unexplained thyroid symptoms, that's another clue worth checking into.

How can I naturally support thyroid hormone balance?

While genetic variants like RTH can't be changed through lifestyle, you can support overall thyroid health with a nutrient-rich diet that includes iodine, selenium, and zinc found in foods like fish, eggs, and nuts. Regular sleep, stress management, and moderate exercise also help your body regulate hormones more smoothly. These habits won't fix a genetic variant, but they can help manage day-to-day symptoms alongside any other steps you take.

When will I get my results?

Results from this gene sequencing test are typically ready within about 7 days after your sample is processed at the lab. Genetic tests like this one take a bit longer than routine blood work because the lab has to closely examine the THRB gene for specific variants. You'll get a notification as soon as your results are posted to your account.

Who should consider this test?

This test is a good fit for people with confusing or inconsistent thyroid lab results, especially when thyroid hormone levels seem high but symptoms don't match. It's also recommended for close relatives of someone already diagnosed with RTH, since the condition is passed down in families. Parents of children with unexplained growth or attention issues alongside odd thyroid readings may also want to consider testing.

What is Resistance to Thyroid Hormone and why does it matter?

Resistance to Thyroid Hormone (RTH) is a genetic condition where the body's cells don't respond normally to thyroid hormone, even though hormone levels in the blood may look normal or high. This happens because of a variant in the THRB gene, which affects how thyroid hormone signals are received by tissues. Understanding whether you have RTH matters because it changes how thyroid symptoms and lab results should be interpreted, and it can prevent unnecessary or incorrect treatment.

What does a positive result mean?

A positive result means a variant was found in your THRB gene that is linked to thyroid hormone resistance. This explains why your body's tissues may not respond to thyroid hormone the way they typically would, even if blood levels appear normal or elevated. It also means close family members may want to consider testing, since RTH is often inherited.

What causes Resistance to Thyroid Hormone?

RTH is caused by an inherited change, or variant, in the THRB gene, which provides instructions for a receptor that helps cells respond to thyroid hormone. When this gene doesn't work properly, cells can't process thyroid hormone signals normally. It's typically passed down from a parent, so having a family member with RTH raises the chances of carrying the same variant.

What should I do if my results are positive?

If your results show a THRB variant, keep a copy of your report handy since it can help explain unusual thyroid lab patterns going forward. Consider letting close biological relatives know, since they may benefit from testing too, especially if they share similar symptoms. If you experience severe symptoms like a very fast heart rate or extreme fatigue, seek medical care right away.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

RTH Gene Test - Thyroid Hormone Resistance Screening

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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