What's this test for?

This test is ideal if you're being evaluated for Lynch syndrome or have a personal or family history of colorectal, endometrial, or other related cancers. It looks at whether your cells are properly repairing DNA mistakes, which can help explain why certain cancers run in families. It's often used alongside other tests when a tumor sample needs closer evaluation for inherited cancer risk.

What's included in this test?

This test uses a lab technique called immunohistochemistry (IHC) to check whether the PMS2 protein is present and working normally in your tissue sample. PMS2 is one of several proteins that work together to fix small errors in your DNA; when it's missing or not functioning, errors can build up and raise cancer risk. A trained specialist interprets the staining pattern and provides a written interpretation with your results.

What happens after I get my results?

Your results will show up in your account along with an explanation of what a normal versus abnormal pattern looks like for this test. If your result suggests a mismatch repair problem, a common next step is additional genetic testing to look for a specific inherited mutation, so you and your family can better understand cancer risk. You can download the full lab report from your account at any time, and if you retest in the future, the trends feature lets you track any changes over time.

How can I naturally support healthy DNA repair?

While you can't change your genes, you can support your body's overall DNA repair processes with simple habits: eat a diet rich in antioxidants (berries, leafy greens, colorful vegetables), avoid smoking and limit alcohol, get regular exercise, and protect your skin from excess UV exposure. Getting enough sleep and managing chronic stress also helps your cells function and repair themselves more efficiently. These habits won't reverse an inherited gene issue, but they support your overall health while you follow up on results.

When will I get my results?

Results for this test are typically ready within about 7 days of your sample being processed. Because this test involves detailed lab analysis and interpretation, it can take a little longer than routine blood work. You'll receive a notification as soon as your results are available in your account.

Who should consider this test?

This test is a good option for people who have been diagnosed with colorectal or endometrial cancer and want to check whether the tumor shows signs of a DNA repair problem. It's also relevant if you have close relatives who developed these cancers at a young age, or a known family history of Lynch syndrome. Discussing your family cancer history is a helpful first step in deciding if this test makes sense for you.

What symptoms indicate I may need this test?

There aren't specific day-to-day symptoms tied directly to PMS2 status, since this test is about cancer risk assessment rather than an active illness. Signs that this test might be relevant include a personal cancer diagnosis at an unusually young age, multiple family members with colorectal or endometrial cancer, or a tumor pathology report suggesting further testing is needed. If any of these apply to you, this test can provide useful information.

What is mismatch repair and why does it matter?

Mismatch repair is your body's built-in spell-checker for DNA — a group of proteins, including PMS2, that scan for and fix small copying errors every time your cells divide. When this system doesn't work properly, errors pile up over time and can eventually lead to cancer, especially in the colon and uterus. Understanding your mismatch repair status helps clarify cancer risk for you and can guide screening decisions for family members too.

What does an abnormal PMS2 result mean?

An abnormal or "deficient" PMS2 result means the protein wasn't detected in the tissue sample, which suggests the DNA mismatch repair system isn't working normally in that tissue. This finding is often followed by genetic testing to look for an inherited mutation, since it can point to Lynch syndrome. Learning this information early allows you and blood relatives to consider more frequent cancer screening going forward.

What should I do if my results are abnormal?

If your PMS2 result comes back abnormal, a practical next step is pursuing genetic testing to identify the underlying cause, since this helps clarify risk for you and your family members. It's also worth sharing the result with close relatives, as they may want to consider related screening. Increasing the frequency of cancer screenings, such as colonoscopies, is a common recommendation when a mismatch repair problem is identified.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

PMS2 IHC Test - Lynch Syndrome & Cancer Risk

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]

PMS2 IHC Test for Lynch Syndrome Cancer Risk

PMS2, IHC with Interpretation

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

What's this test for?

What's included in this test?

What happens after I get my results?

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

Find a lab near you

PMS2 IHC Test for Lynch Syndrome Cancer Risk

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

1,000,000+ blood tests later, here's what our customers say