What's this test for?

This test is ideal if you or someone managing a cancer diagnosis needs more information about the tumor's genetic makeup. It looks for changes in the PIK3CA gene, which are common in breast, endometrial, and colorectal cancers and can affect how a tumor behaves and responds to certain treatments. This test helps if you and your care planning team are trying to better understand treatment options and outlook.

What's included in this test?

This test analyzes the PIK3CA gene for mutations in key hotspot regions that are most commonly linked to cancer. Testing these specific regions matters because changes here are associated with tumor growth, treatment resistance, and overall outlook in several solid tumor types. Covering over 95% of known PIK3CA mutations gives a thorough look at whether this particular genetic change is playing a role in a tumor.

What happens after I get my results?

Your results will be available in your account, with an explanation of what a positive or negative mutation finding means. Because this is a specialized genetic test, next steps typically involve using the result alongside other tumor testing to guide treatment planning rather than routine retesting. A downloadable standard lab report is available in your account for your records or to share as needed. You can also track this and any related results over time using the trends feature.

Who should consider this test?

People who have been diagnosed with breast, endometrial, or colorectal cancer and want more detail on their tumor's genetic profile may consider this test. It's also useful for anyone whose treatment team is exploring targeted therapy options or trying to understand why a prior treatment like cetuximab may not be working well. This test is typically used as part of a broader cancer workup rather than as a standalone screening tool.

What symptoms indicate I may need this test?

This test isn't based on everyday symptoms like fatigue or pain — it's used after a cancer diagnosis has already been made. If you've been diagnosed with a solid tumor, especially breast, endometrial, or colorectal cancer, and treatment isn't working as expected, this test can provide useful genetic information. It's also relevant if a tumor was previously found to be resistant to certain therapies.

What is PIK3CA and why does it matter?

PIK3CA is a gene that gives instructions for making a protein involved in helping cells grow and survive. When this gene has certain mutations, cells can grow out of control, which is a hallmark of cancer. Knowing whether a tumor carries a PIK3CA mutation can help explain how aggressive it might be and whether certain treatments are likely to work.

What does a positive PIK3CA mutation result mean?

A positive result means a mutation was found in the PIK3CA gene, which is seen in a notable percentage of breast, endometrial, and colorectal cancers. This finding has been linked to a less favorable outlook in some cancers and to resistance against certain drug therapies, like cetuximab in colorectal cancer. This information is typically used alongside other test results to help shape a treatment plan.

What does a negative PIK3CA result mean?

A negative result means no mutation was detected in the tested regions of the PIK3CA gene, covering more than 95% of known mutation sites. This doesn't rule out cancer or other genetic changes — it simply means this specific gene alteration isn't likely playing a role. Other tumor markers or genetic tests may still be relevant depending on the full clinical picture.

What causes a PIK3CA mutation?

PIK3CA mutations are typically acquired changes that happen within tumor cells themselves, rather than something inherited or caused by lifestyle choices. These mutations occur as cells divide and their DNA copying process makes errors that go uncorrected. They are considered part of the biology of the tumor rather than something a person did to cause it.

What should I do if my results show a mutation?

If a mutation is found, it's helpful to bring this result into any ongoing conversations about treatment planning, since it may affect which therapies are likely to work best. Keep a copy of your downloadable lab report for your records and any future testing comparisons. Discussing targeted therapy options that specifically address PIK3CA-related cancer growth can be a useful next step.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

PIK3CA Mutation Test - Breast & Colorectal Cancer Insight

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]

PIK3CA Gene Mutation Test for Cancer Genetic Profiling

PIK3CA Mutation Analysis

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

What's this test for?

What's included in this test?

What happens after I get my results?

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PIK3CA Gene Mutation Test for Cancer Genetic Profiling

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

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