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PD-L1 tissue biomarker test guiding pembrolizumab immunotherapy eligibility for cancer patients

PD-L1 Immunotherapy Eligibility Test (Pembrolizumab)

PD-L1 Non-Lung (Pembrolizumab), IHC

  • Check tumor eligibility for immunotherapy treatment
  • Assess PD-L1 protein expression levels
  • Guide personalized cancer treatment decisions
$2040
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you or someone you're caring for has been diagnosed with a specific tumor type and needs to find out whether immunotherapy with KEYTRUDA (Pembrolizumab) could be an option. It looks at a tissue sample to see how much of a protein called PD-L1 is present on tumor cells. Knowing this helps guide treatment planning for certain approved cancer types.

What's included in this test?

This test measures PD-L1 protein expression on tumor cells using a specialized staining method (IHC 22C3 pharmDx) on a tissue sample. This single, focused result matters because it's an FDA-approved way to help identify whether certain tumor types are more likely to respond to Pembrolizumab-based immunotherapy.

What happens after I get my results?

Your results will be available in your account, with the PD-L1 expression level and what it means clearly explained. Since this is a tumor tissue test tied to treatment decisions, the main next step is reviewing the report to understand your PD-L1 status and discussing timing of any further tissue-based testing if your cancer care plan changes. The standard lab report can be downloaded directly from your account for your records. You can also track results over time using the trends feature if repeat testing is ever needed.

How can I naturally support my immune system during cancer treatment?
While no natural remedy replaces targeted cancer treatment, everyday habits can help support your body's overall resilience. Eating a balanced diet with plenty of protein, fruits, and vegetables helps maintain strength during treatment. Regular light activity, adequate sleep, and stress-reduction practices like meditation may also help you feel better day to day. Always coordinate any new supplement or diet changes with your treatment plan.
When will I get my results?
Results are typically ready within about 7 days after your tissue sample is processed at the lab. This timeframe allows for the specialized staining and pathology review needed for an accurate PD-L1 reading. You'll receive a notification as soon as your results are posted to your account.
Who should consider this test?
This test is intended for people with an FDA-approved tumor type who are being considered for Pembrolizumab (KEYTRUDA) immunotherapy. It's typically ordered when a tissue sample is already available for testing. If your tumor type isn't covered by this specific approved test, a broader PD-L1 IHC test with interpretation may be more appropriate.
What symptoms indicate I may need this test?
This isn't a symptom-based test — it's used after a cancer diagnosis to help plan treatment, not to detect new symptoms. If you've already been diagnosed with an eligible tumor type and are exploring immunotherapy options, this test provides useful information for that specific next step. It does not screen for cancer or diagnose new symptoms.
What is PD-L1 and why does it matter?
PD-L1 is a protein some tumor cells use to hide from your immune system, essentially telling immune cells not to attack. When tumors have high levels of PD-L1, they may respond better to immunotherapy drugs like Pembrolizumab, which block this hiding signal. Measuring PD-L1 helps show whether this type of treatment is likely to be a good fit.
What does a high PD-L1 result mean?
A higher PD-L1 expression level generally means the tumor is showing more of this protein, which can make it a stronger candidate for Pembrolizumab-based immunotherapy. This doesn't guarantee a treatment response, but it's one of the key pieces of information used in eligibility decisions. Your full report will explain the specific scoring used for your tumor type.
What should I do if my results are unclear or borderline?
If your PD-L1 result falls into a borderline range, it may be worth discussing whether additional or repeat tissue testing makes sense, especially if a new sample becomes available. Keeping a copy of your report and tracking any future results over time can help clarify patterns. If you have concerns about what a borderline result means for your specific tumor type, seek guidance promptly given the time-sensitive nature of treatment planning.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
PD-L1 Expression (Combined Positive Score) CPS 15
Demo results
Negative (CPS < 1) Positive (CPS ≥ 1)
CPS 15

What this means

A Combined Positive Score of 15 means PD-L1 protein is present on a notable portion of tumor and immune cells in the sample. This positive result suggests the tumor may be a candidate for Pembrolizumab-based immunotherapy, based on FDA-approved scoring for this tumor type.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Find a lab near you

Search Quest Diagnostics and LabCorp locations available through Private MD Labs.

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PD-L1 Immunotherapy Eligibility Test (Pembrolizumab)

  • Check tumor eligibility for immunotherapy treatment
  • Assess PD-L1 protein expression levels
  • Guide personalized cancer treatment decisions
$2040
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.