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Paraneoplastic antibody test for neurological symptoms linked to underlying cancer

Paraneoplastic Antibody Test for Unexplained Neurological Symptoms

Paraneoplastic Antibody Expanded Evaluation w/Reflex to Titer and LB, Serum

  • Detect nerve-related autoimmune antibody activity
  • Screen for hidden tumor warning signs
  • Track unexplained neurological symptom causes
$43870
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you're experiencing unexplained neurological symptoms like muscle weakness, seizures, memory problems, balance issues, or unusual sensations that haven't been explained by other testing. These symptoms can sometimes be caused by your immune system mistakenly attacking nerve cells, often as a reaction to a hidden tumor somewhere else in the body. This evaluation looks for the specific antibodies responsible so the right next steps can be taken.

What's included in this test?

This evaluation checks for a broad panel of antineuronal autoantibodies using several lab methods, since different antibodies are linked to different neurological problems and, sometimes, different types of hidden tumors. Testing multiple antibody types at once increases the chance of catching a rare but important cause behind unexplained neurological symptoms. Confirmatory titer and line blot testing is automatically added when an initial result needs more clarity.

What happens after I get my results?

Your results will appear in your account with each antibody result explained, including whether it falls in the normal or abnormal range. If any antibody is detected, the report will note whether reflex titer or confirmatory line blot testing was performed automatically to clarify the finding. Because these results can be complex, use them as a starting point for further evaluation and keep watch on any new or worsening symptoms. You can download the full lab report anytime and track results over time using the trends feature if you retest.

How can I naturally support nerve and immune health?
While natural remedies cannot treat an autoimmune neurological condition on their own, general nerve-supportive habits include eating a diet rich in B vitamins and omega-3 fatty acids, staying physically active within your ability, prioritizing sleep, and managing stress, since chronic stress can affect immune regulation. Avoiding alcohol and smoking also supports overall nerve and immune function. These steps are supportive, not a substitute for follow-up on abnormal antibody results.
When will I get my results?
Results are typically ready within about 7 days of your sample being processed, though confirmatory reflex testing (titer or line blot) can add a bit more time if it's triggered. You'll see a status update in your account once results are finalized. This turnaround allows time for the detailed immunofluorescence and radioimmunoassay methods this panel relies on.
Who should consider this test?
This test is a good fit for people with unexplained neurological symptoms such as sudden weakness, seizures, memory changes, or coordination problems, especially when no clear cause has been found. It's also useful for people with a known cancer history who develop new neurological symptoms, since paraneoplastic antibodies can sometimes appear before a tumor is even found. It is not intended as a routine screening test for people without symptoms.
What symptoms indicate I may need this test?
Common symptoms linked to paraneoplastic neurological conditions include muscle weakness, difficulty walking or with coordination, seizures, memory or personality changes, vision problems, and unusual sensations like numbness or tingling. Symptoms often develop faster than typical age-related decline and may worsen over weeks rather than years. If you're noticing several of these symptoms together, especially alongside a cancer diagnosis, this test can help identify an underlying cause.
What does a positive antibody result mean?
A positive result means a specific antineuronal antibody was found in your blood, which suggests your immune system may be attacking nerve tissue, sometimes triggered by a hidden tumor elsewhere in the body. The report will note the specific antibody found, since each one is linked to different symptoms and different tumor types. A positive finding is important to act on quickly, since identifying and addressing the underlying cause early can make a real difference.
What causes these antibodies to appear?
These antibodies typically appear when the immune system, while fighting a tumor, mistakenly starts attacking normal nerve cells because they share similar proteins to the tumor cells. In some cases, the antibodies appear without any tumor ever being found, and are instead linked to a separate autoimmune process. Viral infections and other autoimmune conditions can occasionally play a role as well.
What should I do if my results are abnormal?
If any antibody is detected, treat it as a signal to seek further medical evaluation soon, especially imaging or scans to check for an underlying tumor, since early detection matters greatly for these conditions. If you're having severe or rapidly worsening symptoms like seizures or sudden severe weakness, seek emergency care right away. Keep a record of your symptom timeline, as this helps speed up further workup.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Antineuronal Antibody Panel (e.g., Anti-Hu, Anti-Yo, Anti-CV2) Negative
Demo results
Negative Positive
Negative

What this means

A negative result means no antineuronal antibodies were detected, which makes an autoimmune paraneoplastic cause for your symptoms less likely. A positive result means one or more antibodies were found, suggesting your immune system may be reacting against nerve tissue, sometimes linked to a hidden tumor. Any positive finding is typically followed by confirmatory titer and line blot testing.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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Search Quest Diagnostics and LabCorp locations available through Private MD Labs.

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Paraneoplastic Antibody Test for Unexplained Neurological Symptoms

  • Detect nerve-related autoimmune antibody activity
  • Screen for hidden tumor warning signs
  • Track unexplained neurological symptom causes
$43870
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.