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NMO spectrum test for patients with unexplained vision loss or spinal symptoms

NMO Spectrum Antibody Test — Vision & Spinal Symptoms

NMO Spectrum Evaluation (AQP4 with Reflex to MOG), Serum

  • Detect nervous system autoimmune antibody activity
  • Screen for optic nerve inflammation causes
  • Assess unexplained vision or spinal symptoms
$2942
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you're experiencing sudden vision problems, eye pain, or unusual weakness and numbness in your arms or legs that could point to inflammation of your optic nerve or spinal cord. It checks for specific antibodies linked to neuromyelitis optica (NMO) and related conditions, which are sometimes mistaken for other neurological issues. It's especially useful if you've had repeated episodes of optic neuritis or myelitis and want clarity on the underlying cause.

What's included in this test?

This panel looks for specific antibodies that attack proteins in your nervous system, which helps distinguish NMO spectrum disorder from other conditions with similar symptoms like multiple sclerosis. Testing for both antibody types matters because each is linked to a slightly different disease pattern and outlook, so knowing which one is present (if any) helps guide the right path forward.

What happens after I get my results?

Your results will show up in your secure online account with a clear explanation of what's considered a normal versus abnormal range for each antibody tested. If your results come back positive, the report will explain what that may mean and suggest next steps, such as seeking prompt medical care given the seriousness of NMO-related conditions. You can download a standard lab report anytime for your records, and if you retest in the future, our trends feature lets you track changes over time.

How can I naturally support nervous system health?
While there's no natural remedy that treats NMO spectrum disorder itself, supporting your overall nervous system health can help you feel your best. Eating foods rich in omega-3 fatty acids, getting enough vitamin D, staying physically active within your limits, and managing stress through good sleep and relaxation techniques are all supportive habits. These steps won't replace appropriate care for a positive result, but they can complement your overall wellness routine.
When will I get my results?
Results are typically ready within about 7 days of your sample being received at the lab. This slightly longer turnaround is because the test involves specialized antibody analysis, and if your initial screen is positive, a reflex test for MOG antibodies is automatically run, which can add a little more time. You'll get a notification as soon as your results are posted to your account.
Who should consider this test?
This test is a good fit for anyone who has had one or more episodes of unexplained optic neuritis (eye nerve inflammation) or transverse myelitis (spinal cord inflammation) without a clear cause. It's also useful if you've been told you might have multiple sclerosis but your symptoms or scans don't quite fit that picture. People with a family history of autoimmune neurological conditions may also want this clarity.
What symptoms indicate I may need this test?
Common symptoms include sudden or worsening vision loss, eye pain especially with movement, numbness or weakness in your limbs, loss of bladder or bowel control, or severe fatigue paired with these neurological changes. Repeated episodes of these symptoms, especially if they come and go, are a stronger signal that this testing could be helpful. If your symptoms are severe or rapidly worsening, seek medical care right away.
What does a positive AQP4 or MOG antibody result mean?
A positive result means antibodies were found that are strongly associated with NMO spectrum disorder, a condition where your immune system mistakenly attacks parts of your nervous system. This finding is significant and typically calls for prompt medical attention, since NMO can progress quickly and early management matters. It does not automatically mean you have every symptom of the disease, but it does explain a probable cause behind neurological episodes you may have experienced.
What does a negative result mean if I still have symptoms?
A negative result means these particular antibodies weren't detected, but it doesn't fully rule out NMO spectrum disorder, since a small number of people with the condition test negative for both antibodies. If your symptoms continue or worsen, it's worth pursuing further evaluation to understand what's causing them. Keeping a symptom log with dates and severity can be helpful information for any follow-up testing.
How often should I retest?
If your first test is negative but you continue having symptoms, retesting after a new flare-up or after a few months can sometimes catch antibodies that weren't detectable earlier. If you test positive, retesting isn't usually about confirming the result but rather about monitoring your condition over time in coordination with your ongoing care. Use the trends feature in your account to keep a clear timeline of your results.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
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US-licensed doctors have your back if things get unclear.
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Save a trip to the doctor, go directly to the lab
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Results explained in simple language
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Demo results
Aquaporin-4 (AQP4) Antibody, IgG Negative
Demo results
Negative Positive
Negative

What this means

A negative result means AQP4 antibodies were not detected in your blood sample, which makes NMO spectrum disorder less likely to be the cause of your symptoms. However, a small percentage of people with the condition still test negative, so ongoing symptoms should not be ignored.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
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Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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NMO Spectrum Antibody Test — Vision & Spinal Symptoms

  • Detect nervous system autoimmune antibody activity
  • Screen for optic nerve inflammation causes
  • Assess unexplained vision or spinal symptoms
$2942
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.