What's this test for?

This test is ideal if you're experiencing unusual symptoms like fatigue, itching, unexplained blood clots, or abnormal blood counts found on a routine blood test. It helps identify gene mutations linked to rare blood disorders called myeloproliferative neoplasms, which cause the bone marrow to make too many blood cells. This panel is often used when a standard blood test raises concerns about your red cells, white cells, or platelets and further answers are needed.

What's included in this test?

This panel looks at several genes known to drive certain blood disorders, checking for changes that cause the bone marrow to overproduce blood cells. Testing multiple genes together gives a fuller picture than checking just one, since different patients with the same condition can have different underlying mutations. This combined approach helps pinpoint the specific disease process at work.

What happens after I get my results?

Your results will be available in your account, with each mutation result explained in plain terms along with what a positive or negative finding means. If a driver mutation is found, next steps typically involve correlating the result with your blood counts and any bone marrow findings, and possibly repeating testing over time to track disease activity. You can download a standard lab report directly from your account for your records, and use the trends feature to monitor any related blood work over time. If results suggest a mutation but symptoms are severe, such as signs of a blood clot or stroke, seek medical care right away.

How can I naturally support healthy blood cell production?

While gene mutations themselves can't be changed through lifestyle, you can support your overall blood and marrow health with regular exercise, staying well hydrated, and eating a balanced diet rich in iron, folate, and B12 if your counts show deficiencies. Avoiding smoking and limiting alcohol can also reduce added stress on your bone marrow and blood vessels. Managing stress and getting enough sleep support healthy blood pressure and circulation, which matters if you're at higher risk for clotting. These steps are supportive only and don't replace medical care if you have a diagnosed condition.

When will I get my results?

Results are typically ready within about 7 days after your sample is processed, since this test uses detailed next-generation sequencing technology that takes time to analyze multiple genes accurately. You'll receive a notification once your results are posted to your secure online account. This turnaround allows the lab to thoroughly check for subtle mutations that simpler tests might miss.

Who should consider this test?

This test is a good fit for people whose blood work shows unexplained high red blood cell counts, high platelet counts, or unusual clotting events, since these can be early signs of a myeloproliferative disorder. It's also useful for anyone already suspected of having polycythemia vera, essential thrombocythemia, or primary myelofibrosis who needs a more definitive answer. People with a family history of blood disorders and unclear symptoms may also benefit from this deeper look.

What symptoms indicate I may need this test?

Common symptoms linked to these blood disorders include persistent fatigue, itching (especially after a warm shower), night sweats, unexplained weight loss, and a feeling of fullness from an enlarged spleen. Some people notice frequent headaches, dizziness, or blurred vision, while others experience unusual bruising or blood clots. If you have a combination of these symptoms along with abnormal blood counts, this panel can help clarify what's going on.

What does a positive JAK2, CALR, or MPL result mean?

A positive result means one of these genes has a mutation that's known to drive overproduction of blood cells in the bone marrow. This supports a diagnosis of a myeloproliferative neoplasm, and the specific gene involved can help determine which condition you have and guide the right treatment approach. The report will note which gene tested positive and what that typically means for diagnosis.

What does a negative result mean?

A negative result means none of the four genes tested showed the specific mutations this panel screens for, but it doesn't completely rule out a myeloproliferative disorder. About 1 in 10 people with these conditions test negative on this core panel and may need an expanded gene panel to find rarer mutations. Your results should be looked at together with your blood counts and any bone marrow findings for a complete picture.

How often should I retest?

If you're diagnosed with a mutation-positive condition, retesting frequency depends on how your disease is being monitored, but many people recheck blood counts every few months and repeat mutation testing periodically to track treatment response. If your result was negative but symptoms continue, retesting or moving to an expanded panel may be worthwhile if new symptoms develop. Discuss timing with whoever is managing your ongoing blood work.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

MPN Diagnostic Panel - JAK2, CALR & MPL Gene Test

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]