Why Private MD Labs?
90-day money-back guarantee Lab order in minutes Save a trip to the doctor Low prices since 2005 Labs within 2 miles
Genetic mutation test for patients evaluating myeloproliferative neoplasm risk factors

MPL Gene Mutation Test for Blood Disorder Evaluation

MPL Mutation Analysis

  • Detect genetic causes of high platelets
  • Screen for rare blood cell disorders
  • Assess your risk for clotting conditions
$1133
LegitScript certified merchant
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you're experiencing unexplained high platelet counts, unusual blood clotting, or other signs that have prompted questions about a blood disorder. It looks for a specific genetic change linked to conditions where the bone marrow makes too many blood cells. It's often used alongside other blood work when someone has abnormal blood counts that need further investigation.

What's included in this test?

This test uses advanced DNA sequencing technology to look specifically at a gene involved in how your body regulates platelet production. It matters because certain changes in this gene are strongly linked to specific blood disorders, so finding or ruling out this change helps clarify what's happening in your body. The test is highly targeted, focusing only on the regions of the gene most associated with these conditions.

What happens after I get my results?

Your results will show up in your online account along with an explanation of what a positive or negative finding means. If a mutation is found, next steps typically involve closer monitoring of your blood counts and discussing findings in the context of your overall health picture; if not found, your results still help narrow down what might be causing your symptoms. You can download the full lab report directly from your account at any time. Because this is a one-time genetic test, ongoing trend tracking isn't usually needed, but any related blood counts you test in the future can be tracked over time.

What symptoms indicate I may need this test?
Common signs that might lead to this test include unexplained fatigue, easy bruising or bleeding, headaches, dizziness, or an enlarged spleen. Some people are also referred for this test after routine bloodwork shows unusually high platelet counts. If you've had unexplained blood clots or a family history of blood disorders, this test may also be relevant.
When will I get my results?
Results are typically ready within about 7 days of your sample being received at the lab. This is because the test involves detailed genetic sequencing, which takes more time than standard blood work. You'll get a notification as soon as your results are available in your account.
Who should consider this test?
This test is a good fit for people who've had abnormal blood count results, particularly high platelet levels, and want to understand the underlying cause. It's also relevant for those with a family history of blood disorders or unexplained clotting events. People already being evaluated for a myeloproliferative condition often use this test to get more specific answers.
How can I naturally support healthy blood cell production?
While genetic changes can't be reversed through lifestyle, staying well-hydrated, eating a balanced diet rich in iron and folate, and avoiding smoking can support overall blood health. Regular movement helps circulation and may reduce clotting risk. Managing stress and getting quality sleep also supports your body's overall function, though these steps don't replace medical monitoring if a mutation is found.
What causes changes in this gene?
These genetic changes usually happen spontaneously in blood-forming cells over a person's lifetime rather than being inherited from parents. They're not caused by anything you did — they occur naturally as cells divide and occasionally pick up errors in their DNA. Age and, in rare cases, other blood conditions can increase the likelihood of these changes appearing.
What should I do if my results are abnormal?
If a mutation is detected, it's a good idea to keep a close eye on any symptoms like unusual bruising, headaches, or fatigue, and consider more frequent blood count monitoring. Keep a record of your results so you can compare them over time. If you experience severe symptoms such as sudden severe headache, vision changes, or signs of a blood clot, seek medical care right away.
How often should I retest?
Since this is a genetic test looking for a mutation that doesn't change over time, you generally don't need to repeat it once you've had a clear result. However, related blood counts (like platelet levels) may be worth checking periodically if you're monitoring a known condition. Your original result stays relevant for future reference.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
MPL Gene Mutation (Exon 10, Codons 505/515) Negative
Demo results
Negative (No Mutation Detected) Positive (Mutation Detected)
Negative

What this means

A negative result means no mutation was found in the tested regions of the MPL gene. This makes a myeloproliferative neoplasm linked to this specific gene less likely, though other causes of abnormal blood counts should still be considered. A positive result would mean a mutation was detected, which is associated with conditions like essential thrombocythemia or primary myelofibrosis.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Find a lab near you

Search Quest Diagnostics and LabCorp locations available through Private MD Labs.

Find a lab

MPL Gene Mutation Test for Blood Disorder Evaluation

  • Detect genetic causes of high platelets
  • Screen for rare blood cell disorders
  • Assess your risk for clotting conditions
$1133
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
Ask Me Anything

Your 24/7 Personal Lab Guide

Hi. Tell me what you want to check. I'll find the right blood test for you.

Just now
For informational purposes only. Not medical advice.