What's this test for?

This test is ideal if you're experiencing a family history of early-onset cancers, multiple cancer diagnoses in close relatives, or several types of tumors showing up across generations. It's also useful if you've personally had cancer at a young age and want to understand whether an inherited gene change is behind it. Knowing your genetic status can help guide decisions about screening and monitoring going forward.

What's included in this test?

This test looks at the TP53 gene using two methods together: sequencing to catch small spelling changes in the gene's code, and deletion/duplication analysis to catch larger missing or extra pieces. Using both methods matters because either type of change can turn off the gene's normal cancer-protection function, so testing only one way could miss a mutation.

What happens after I get my results?

Your results will show up in your account, with a clear explanation of what a positive or negative finding means for the TP53 gene. If a mutation is found, the report will outline why closer and earlier cancer screening is recommended, since early detection makes a real difference with Li-Fraumeni-related tumors. You can download the full lab report from your account at any time, and because this is a one-time genetic result, there's no need for retesting, though you can keep it on file and track any related follow-up tests over time.

How can I naturally support healthy cell function?

While no lifestyle habit can change your genes, healthy daily choices support your body's natural ability to repair cell damage. Eating a diet rich in vegetables, fruits, and antioxidants, avoiding tobacco and excess alcohol, staying physically active, and limiting unnecessary radiation exposure (like extra X-rays or CT scans) are all sensible steps. These habits are especially worth prioritizing if you carry a TP53 mutation, since your cells may have less natural protection against damage.

When will I get my results?

Results are typically ready within about 7 days after your sample is processed at the lab. You'll receive a notification once your report is available in your account, and you can log in anytime to view or download it.

Who should consider this test?

This test is a good fit for people with a personal or family history of early-onset cancers such as breast cancer, sarcomas, brain tumors, leukemia, or adrenal gland tumors. It's also worth considering if multiple family members across generations have had different types of cancer, or if a relative has already tested positive for a TP53 mutation. Talking through your family's cancer history with a genetic counselor before testing can help you decide if this is the right step.

What symptoms or history suggest I may need this test?

Red flags include being diagnosed with cancer before age 45, having multiple different primary cancers yourself, or having close relatives diagnosed with cancer at unusually young ages. A family pattern that includes soft tissue sarcomas, bone cancers (osteosarcoma), breast cancer, brain tumors, leukemia, or adrenal gland cancer is a particularly strong signal. If several of these show up in your family tree, genetic testing can help clarify your risk.

What is Li-Fraumeni Syndrome and why does it matter?

Li-Fraumeni Syndrome is an inherited condition caused by changes in the TP53 gene, which normally acts like a built-in safety switch that stops cells from growing out of control. When this gene doesn't work properly, the body loses some of its natural defense against tumors, leading to a much higher lifetime risk of several cancer types starting at a young age. Understanding whether you carry this change matters because it changes how early and how often cancer screening should happen.

What does a positive TP53 result mean?

A positive result means a change was found in the TP53 gene that is known to raise the risk of developing certain cancers over your lifetime. It does not mean you will definitely get cancer, but it does mean earlier and more frequent screening is a smart next step. Your report will explain the specific mutation found and why increased monitoring is recommended.

What should I do if my results come back positive?

If your result is positive, the most useful next step is starting an enhanced cancer screening schedule, since catching tumors early greatly improves outcomes with Li-Fraumeni Syndrome. It's also worth sharing your result with blood relatives, since they may want to get tested too, given the condition runs in families. Consider connecting with a genetic counselor to build a personalized long-term monitoring plan based on your specific mutation.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

TP53 Gene Test - Li-Fraumeni Cancer Risk Screening

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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