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Genetic cancer risk test for families with juvenile polyposis or colorectal cancer history

Juvenile Polyposis Genetic Test — BMPR1A & SMAD4

Juvenile Polyposis Panel (BMPR1A and SMAD4)

  • Screen for inherited colon cancer risk
  • Detect gene changes causing polyps
  • Assess family history cancer risk
$11592
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
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Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay
  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

What's this test for?

This test is ideal if you're concerned about a family history of juvenile polyposis syndrome, multiple stomach or colon polyps, or a family pattern of colorectal or gastric cancer. It helps you understand whether you carry a gene change linked to a much higher lifetime risk of these cancers. Knowing your status can guide decisions about earlier or more frequent cancer screening.

What's included in this test?

This test looks at two specific genes tied to juvenile polyposis syndrome. Checking both genes together gives a more complete picture, since a pathogenic change in either one can independently explain the condition and its cancer risks.

What happens after I get my results?

Your results will show up in your account along with an explanation of what a positive or negative finding means. If a pathogenic variant is found, the report explains why earlier and more frequent colon and stomach screening is recommended, and you can use this information when scheduling those screenings. A standard lab report is available to download directly from your account at any time. You can also track this result over time using the trends feature, which is useful if other family members test later.

How can I naturally support digestive and colon health?
While no lifestyle change can undo a gene variant, you can support your digestive system with a diet high in fiber, fruits, and vegetables, and by limiting red and processed meats. Regular physical activity, avoiding tobacco, and limiting alcohol are also linked to lower colorectal cancer risk. These habits are especially useful alongside closer medical screening if you carry a JPS-related gene change.
When will I get my results?
Results are typically ready within about 7 days of your sample being processed at the lab. You'll get a notification once your results are posted to your account so you can log in and review them right away.
Who should consider this test?
This test is a good option if you have a personal or family history of multiple juvenile polyps, unexplained colon or stomach polyps at a young age, or relatives already diagnosed with juvenile polyposis syndrome. It's also worth considering if a close family member has already tested positive for a BMPR1A or SMAD4 variant. Testing can help you and your family make informed decisions about future cancer screening timing.
What symptoms indicate I may need this test?
Signs that may point to juvenile polyposis syndrome include rectal bleeding, anemia, abdominal pain, or polyps found during a colonoscopy or endoscopy, especially at a younger age than typical. A family history of multiple polyps or early colorectal or stomach cancer is another strong reason to consider testing. If you've had several polyps removed over the years, this test can help explain why.
What is Juvenile Polyposis syndrome and why does it matter?
Juvenile Polyposis syndrome is an inherited condition that causes multiple polyps to grow in the stomach and intestines, starting sometimes in childhood. It matters because these polyps raise your lifetime risk of colorectal cancer to 40-50% and gastric cancer risk up to 21% if the stomach has many polyps. Identifying the condition early allows for closer monitoring, which can catch problems before they become cancer.
What does a positive result mean for my family members?
If you test positive for a BMPR1A or SMAD4 variant, your parents, siblings, and children each have roughly a 50% chance of carrying the same gene change. It's a good idea to share this information with close relatives so they can consider testing too. Early awareness in a family lets everyone start appropriate screening sooner rather than later.
How often should I retest or get rescreened?
This is a one-time genetic test, since your gene sequence doesn't change over time, so retesting the same panel isn't necessary. Instead, if your result is positive, the focus shifts to regular colonoscopies and upper endoscopies on a schedule based on your results. Check with the screening guidance in your report for suggested timing between procedures.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
BMPR1A/SMAD4 Pathogenic Variant Status Negative
Demo results
Negative (No Variant Detected) Positive (Variant Detected)
Negative

What this means

A negative result means no pathogenic variant was found in the BMPR1A or SMAD4 genes tested. This lowers the chance that Juvenile Polyposis syndrome explains your symptoms or family history, though it doesn't rule out all hereditary cancer risk.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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Juvenile Polyposis Genetic Test — BMPR1A & SMAD4

  • Screen for inherited colon cancer risk
  • Detect gene changes causing polyps
  • Assess family history cancer risk
$11592
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.