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JC Polyoma Virus urine PCR test for immunocompromised patients at risk of PML

JC Polyoma Virus Urine Test for Immunosuppressed Patients

JC Polyoma Virus DNA, Qualitative, Real-Time PCR, Urine

  • Detect active JC virus infection
  • Screen immune system related risks
  • Monitor neurological health concerns
$1505
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
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Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay
  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

What's this test for?

This test is ideal if you're immunosuppressed and your care situation calls for checking for JC Polyoma Virus, especially if you have HIV/AIDS, are on immune-suppressing medication, or have any condition that weakens your immune system. It looks for signs of the virus that can lead to a serious brain condition called progressive multifocal leukoencephalopathy (PML) in people with weakened immunity. It's not typically needed for healthy individuals since the virus is common and usually harmless.

What's included in this test?

This test checks specifically for the genetic material (DNA) of JC Polyoma Virus in a urine sample using a highly sensitive method called PCR. It's a single, targeted test rather than a panel, so no other biomarkers are included.

What happens after I get my results?

Your results will be available in your account, with a plain-language explanation of what a positive or negative finding means. If your result is positive and you have a weakened immune system, next steps may include closer monitoring for neurological symptoms like confusion, vision changes, or weakness, since these could signal PML developing. You can download the standard lab report directly from your account at any time, and if retesting is recommended later on, you can track results over time using the trends feature.

When will I get my results?
Results are typically ready within about 7 days of your sample being processed at the lab. You'll get a notification once your report is available, and you can log into your account any time after that to view the full details.
Who should consider this test?
This test is mainly for people with significantly weakened immune systems, such as those living with HIV/AIDS, organ transplant recipients, or people taking certain immune-suppressing medications for autoimmune conditions. It's also sometimes used to monitor pregnant women, since JC virus can appear in urine during pregnancy without causing illness. Healthy individuals with normal immune function typically don't need this test.
What symptoms indicate I may need this test?
If you have a weakened immune system and start noticing new neurological symptoms — like confusion, trouble speaking, vision problems, weakness on one side of the body, or coordination issues — this test may help identify whether JC virus activity could be a contributing factor. These symptoms combined with known immune suppression (from HIV, transplant medications, or certain autoimmune drugs) are the main reasons this test gets ordered. It's not a routine test for general symptoms like fatigue or minor illness.
What is JC Polyoma Virus and why does it matter?
JC Polyoma Virus is a very common virus that most people are exposed to at some point in life without ever getting sick from it — in fact, having antibodies to it is normal and doesn't mean anything is wrong. The concern only arises in people with severely weakened immune systems, where the virus can reactivate and damage the brain's protective coating, leading to a serious condition called PML. That's why this urine DNA test, rather than an antibody blood test, is used to check for active virus in at-risk individuals.
What does a positive result mean?
A positive result means JC virus DNA was detected in your urine, which shows the virus is active in your body. In someone with a healthy immune system this is usually not concerning, since around 3% of pregnant women and many others can have detectable virus without any disease. But if you're immunosuppressed, a positive result combined with neurological symptoms may point toward PML and calls for prompt attention — seek medical care right away if you're experiencing new neurological symptoms.
How often should I retest?
If you're immunosuppressed and being monitored for JC virus activity, retesting frequency depends on your individual risk factors and whether you're experiencing any new symptoms. Some people are checked periodically as part of ongoing immune status monitoring, while others may only need one-time testing if a specific concern comes up. Using the trends feature in your account can help you and your records keep track of results if you test more than once.
What should I do if my results are abnormal?
If your result is positive and you have a healthy immune system, it usually doesn't require any action since the virus is common and typically harmless. If you're immunosuppressed and your result is positive, especially alongside new neurological symptoms like confusion, weakness, or vision changes, seek medical care promptly since this combination needs urgent evaluation. Keeping a record of your symptoms and this result in your account can help track any changes over time.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
JC Polyoma Virus DNA Negative
Demo results
Negative Positive
Negative

What this means

A negative result means no JC virus DNA was detected in your urine sample. This is the expected result for most people, including those with healthy immune systems, and does not suggest any disease.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
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Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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JC Polyoma Virus Urine Test for Immunosuppressed Patients

  • Detect active JC virus infection
  • Screen immune system related risks
  • Monitor neurological health concerns
$1505
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.