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Prenatal screening test for pregnant women assessing Down syndrome and neural tube defect risk

Integrated Screen Part 2 – Prenatal Down Syndrome Test

Integrated Screen, Part 2

  • Screen for Down syndrome risk factors
  • Check neural tube defect chances
  • Assess Trisomy 18 pregnancy risk
$2930
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
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Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay
  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

What's this test for?

This test is ideal if you're pregnant and want to understand your baby's risk for Down Syndrome (Trisomy 21), Trisomy 18, or a neural tube defect. It's a standard part of prenatal care that gives you information early in pregnancy so you can plan ahead and discuss next steps if needed. Many women take this test simply for peace of mind during a normal pregnancy checkup.

How should I prepare for this test?

How can I naturally support a healthy pregnancy while waiting for results? Eating a balanced diet with folate-rich foods, staying hydrated, taking your prenatal vitamins, and getting regular rest all support healthy fetal development. Light exercise (as approved for your pregnancy stage), avoiding alcohol and tobacco, and managing stress through good sleep habits are simple, actionable steps every pregnant person can take. These habits won't change your screening results, but they support overall pregnancy health.

What's included in this test?

This screening combines several maternal blood markers along with your personal risk factors to estimate the chances of chromosomal conditions and neural tube defects. Each marker reflects a different aspect of fetal development, and combining them gives a more accurate risk picture than any single marker alone. This is why it's typically done in two parts across different weeks of pregnancy.

What happens after I get my results?
Your results will be available in your account, with each value's normal range explained in plain language so you know what it means for your pregnancy. If a result comes back showing increased risk, the report will outline what that means and suggest reasonable next steps, such as additional testing or closer monitoring. You can download a standard lab report from your account at any time, and if you have this type of screening again in a future pregnancy, you can track results over time using the trends feature.
When will I get my results?
Results are typically ready within about 7 days after your sample is collected. This gives the lab time to run the specific combination of markers used in this screening and calculate an accurate risk estimate. You'll be notified as soon as your results are posted to your account.
Who should consider this test?
This test is a good fit for anyone who is pregnant and wants early information about their baby's risk for certain chromosomal conditions or neural tube defects. It's especially relevant if you're in your second trimester and already completed part 1 of the integrated screen, since both parts work together for the most accurate results. It's also commonly chosen by women with a family history of genetic conditions or those who simply want extra reassurance during pregnancy.
What symptoms indicate I may need this test?
This isn't a symptom-based test — there are no physical signs that would tell you to get it. Instead, it's a routine part of prenatal care recommended for all pregnant women, regardless of how you're feeling, to screen for chromosomal and neural tube conditions early in pregnancy.
What is a neural tube defect and why does it matter?
A neural tube defect happens when the baby's spine or brain doesn't develop completely and normally in very early pregnancy, with spina bifida being one common example. Screening for this early gives you time to plan for any additional care or monitoring your baby might need after birth. Catching this early is one of the main reasons this screening is considered standard-of-care.
What should I do if my results are abnormal?
An increased-risk result doesn't mean your baby definitely has a condition — it means further testing is recommended to get a clearer answer. The report will explain what your specific numbers mean and what type of follow-up testing is typically suggested, such as more detailed imaging or diagnostic testing. Try not to panic; screening tests like this one are designed to flag who might benefit from a closer look, not to give a final diagnosis.
How often should I retest?
This screening is timed to specific weeks of pregnancy and is generally done once per pregnancy as a two-part test (an earlier and a later blood draw). You wouldn't retest within the same pregnancy unless specifically advised to due to timing or sample issues. If you become pregnant again in the future, you would complete the full screening process again during that pregnancy.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
AFP (Alpha-Fetoprotein) Risk Score 1:2500 risk (Low Risk)
Demo results
Screen Positive (Increased Risk) Screen Negative (Low Risk)
1:2500 risk (Low Risk)

What this means

A result of 1:2500 means the calculated chance of the pregnancy being affected is low, falling below the screen-positive cutoff. This is considered a reassuring result, though screening tests estimate probability and are not a final diagnosis. Most women with low-risk results go on to have typical prenatal care with no further testing needed.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Find a lab near you

Search Quest Diagnostics and LabCorp locations available through Private MD Labs.

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Integrated Screen Part 2 – Prenatal Down Syndrome Test

  • Screen for Down syndrome risk factors
  • Check neural tube defect chances
  • Assess Trisomy 18 pregnancy risk
$2930
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.