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Hydroxyproline test for monitoring bone health, osteoporosis treatment, and bone healing progress

Blood Test for Bone Health and Osteoporosis Monitoring

Hydroxyproline, Plasma

Google
3,138 reviews
  • Checks bone collagen formation levels.
  • Monitors bone growth and healing.
  • Assesses osteoporosis treatment effectiveness.
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you're being treated for osteoporosis and want to monitor how well your treatment is working. It helps track bone collagen formation, which is essential for understanding bone growth, healing after fractures, and the effectiveness of bone-building therapies. Many people use this test when they need to assess bone health changes over time or evaluate recovery from bone injuries.

How should I prepare for this test?

Fasting: 4 hours

An overnight fast is preferred, or at least avoid eating for 4 hours before your test. This fasting period helps ensure accurate results by minimizing dietary influences on your hydroxyproline levels. You can drink water during the fasting period.

What's included in this test?

This test measures plasma hydroxyproline, an amino acid that's a key component of collagen in your bones. Elevated levels indicate active bone collagen breakdown, which helps doctors assess bone turnover rates, monitor osteoporosis progression, and evaluate how well bone-building treatments are working. This single marker provides valuable insight into your bone metabolism and healing processes.

What happens after I get my results?
You'll receive detailed doctor notes in simple language explaining what your hydroxyproline levels mean for your bone health and healing. These notes include personalized recommendations like dietary changes to support bone strength, supplement suggestions, or whether you should follow up with your doctor about treatment adjustments. You'll also get the standard lab report and can track your hydroxyproline levels over time using our trends feature to see how your bone health is responding to treatment or lifestyle changes.
Who should consider getting this test?
This test is particularly valuable for people diagnosed with osteoporosis who are undergoing treatment and need to monitor progress. It's also useful for individuals recovering from bone fractures, those with conditions affecting bone metabolism, people with a family history of bone disorders, or anyone whose doctor wants to assess bone collagen formation and breakdown rates.
What symptoms indicate I may need this test?
You might need this test if you've experienced frequent bone fractures, have been diagnosed with osteoporosis, or notice symptoms like bone pain, loss of height, or a stooped posture. It's also important if you're experiencing slower-than-expected healing after a fracture or if your doctor suspects issues with bone formation or excessive bone breakdown.
How can I naturally support my bone health?
Supporting bone health starts with getting adequate calcium through dairy products, leafy greens, and fortified foods, along with vitamin D from sunlight and supplements if needed. Weight-bearing exercises like walking, jogging, or resistance training help strengthen bones, while avoiding smoking and limiting alcohol intake protects bone density. Ensuring adequate protein intake and including vitamin K-rich foods like broccoli and kale can also support bone formation.
What is hydroxyproline and why does it matter?
Hydroxyproline is an amino acid found almost exclusively in collagen, the main structural protein in bones, skin, and connective tissue. When bone collagen breaks down, hydroxyproline is released into your bloodstream, so measuring it helps assess bone turnover and metabolism. Higher levels can indicate increased bone breakdown, which is important for monitoring osteoporosis and evaluating treatment effectiveness.
What does high hydroxyproline mean?
High hydroxyproline levels typically indicate increased bone collagen breakdown, which can suggest active bone loss or turnover. This may be seen in conditions like osteoporosis, Paget's disease, bone metastases, or hyperparathyroidism. If your levels are elevated, it could mean your bones are breaking down faster than they're rebuilding, which may require medical attention or treatment adjustments.
How often should I retest my hydroxyproline levels?
If you're being treated for osteoporosis or a bone disorder, your doctor will typically recommend retesting every 3-6 months to monitor treatment effectiveness and bone metabolism changes. Once your condition stabilizes and treatment shows positive results, testing frequency may decrease to every 6-12 months. Your healthcare provider will determine the best schedule based on your individual situation and treatment response.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Hydroxyproline 4.8 mg/L
Demo results
Low Optimal 0.5 - 3.5 High
4.8 mg/L

What this means

Your hydroxyproline levels are elevated, which indicates increased bone collagen breakdown. This suggests active bone turnover and may mean your bones are breaking down faster than they're rebuilding, which is common in osteoporosis or during bone healing processes.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Blood Test for Bone Health and Osteoporosis Monitoring

Google
3,138 reviews
  • Checks bone collagen formation levels.
  • Monitors bone growth and healing.
  • Assesses osteoporosis treatment effectiveness.

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.