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HPV mRNA test for women with abnormal Pap smear or HPV risk concerns

HPV mRNA Test with High-Risk Genotype Reflex

HPV mRNA E6/E7 with Reflex to HPV Genotypes 16, 18/45

  • Screen for high-risk HPV activity
  • Detect cervical cancer risk early
  • Monitor abnormal Pap smear follow-up
$480
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay
  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

What's this test for?

This test is ideal if you're experiencing concerns after an abnormal Pap smear or want to understand your risk for cervical changes linked to high-risk HPV. It checks for active viral activity from HPV types most linked to cervical cancer, rather than just detecting past exposure. It's a helpful next step for anyone who wants clearer answers about their HPV status and what it might mean for their long-term health.

What's included in this test?

This test detects active messenger RNA (mRNA) from 14 high-risk HPV types, which tells you whether the virus is actively using cell machinery to make proteins that can disrupt normal cell cycle control. If the initial result is positive, the test automatically reflexes to identify whether HPV type 16 or 18/45 specifically are present, since these carry the highest risk for cervical cell changes. This combination gives a more complete risk picture than a standard HPV DNA test alone.

What happens after I get my results?

Your results will show up in your account with a clear explanation of what a positive or negative result means for the E6/E7 mRNA marker and any reflex genotype results. If your result is positive, next steps typically involve closer monitoring or follow-up testing based on established screening guidelines, since this doesn't mean cancer is present, only that increased surveillance may be worthwhile. You can download a standard lab report anytime, and if you retest in the future, the trends feature lets you track changes over time.

How can I naturally support cervical health?
Supporting your immune system is one of the best ways to help your body manage or clear HPV naturally, since most infections resolve on their own within one to two years. Quitting smoking is one of the most impactful changes, as tobacco use is strongly linked to persistent HPV infection and slower viral clearance. Eating a diet rich in fruits, vegetables, and antioxidants, managing stress, and getting enough sleep also support a stronger immune response.
When will I get my results?
Results are typically ready within about 7 days of your sample being processed at the lab. You'll get a notification as soon as your results are available in your secure online account, where you can view the report and download it at any time.
Who should consider this test?
This test is a good fit if you've had an abnormal Pap smear result and need more information, or if you're following up on a previous high-risk HPV diagnosis. It's also useful for anyone who wants a more detailed risk assessment than a standard screening provides. People being monitored after treatment for cervical cell changes may also find this test valuable for ongoing surveillance.
What symptoms indicate I may need this test?
HPV infection itself usually causes no symptoms, which is why testing rather than symptom-watching is the main way to catch it. Some people never notice anything unusual even when high-risk HPV is present and active. If you've had abnormal cervical cell findings on a routine exam, that's typically the trigger for this more specific follow-up test rather than any physical symptom.
What does a positive result mean?
A positive E6/E7 mRNA result means the virus is actively producing proteins that can interfere with normal cell growth control, which raises your risk of developing precancerous cervical changes over time. It does not mean you have cancer or will definitely develop it, since many active infections still clear naturally. The reflex genotype result narrows down whether you carry HPV 16 or 18/45, the two types associated with the highest risk, which can inform how closely your cervical health should be monitored.
How often should I retest?
Retesting cadence depends on your prior results and screening history, but many people who test positive are advised to retest or follow up within 6 to 12 months to see if the infection has cleared. If your result is negative, following routine cervical cancer screening guidelines for your age group is generally sufficient. Keeping a consistent testing schedule through your account's trends feature makes it easier to spot changes early.
What should I do if my results are abnormal?
If your result comes back positive, the most useful next step is closer follow-up testing or repeat screening according to standard timelines, since a single positive result doesn't confirm a serious problem. Focus on immune-supportive habits like quitting smoking, eating well, and reducing stress while you wait for follow-up. If you experience unusual bleeding, pain, or discharge, seek medical care promptly rather than waiting for a scheduled retest.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
HPV E6/E7 mRNA (14 High-Risk Types) Negative
Demo results
Negative Positive
Negative

What this means

A negative result means no active E6/E7 mRNA was detected from the 14 high-risk HPV types tested, suggesting a low current risk of HPV-related cervical cell changes. This is a reassuring result and typically means no reflex genotyping was needed.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Find a lab near you

Search Quest Diagnostics and LabCorp locations available through Private MD Labs.

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HPV mRNA Test with High-Risk Genotype Reflex

  • Screen for high-risk HPV activity
  • Detect cervical cancer risk early
  • Monitor abnormal Pap smear follow-up
$480
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.