What's this test for?

This test is ideal if you're about to start allopurinol for gout or high uric acid and want to know if you're at risk for a severe skin reaction. It's also useful if you have gout and are of Han Chinese, Thai, or Korean descent, since these groups have a higher chance of carrying the gene variant linked to this risk. Knowing your status ahead of time can help you and the person prescribing your medication choose a safer treatment path.

What's included in this test?

This test looks at a single gene marker rather than a panel of biomarkers, so there's just one result to interpret: whether you carry the HLA-B*58:01 variant. This genetic marker matters because it's strongly linked to a serious, sometimes life-threatening skin reaction (SCAR) that can occur in some people who take allopurinol. Testing before starting the medication lets you avoid this risk altogether rather than discovering it after a reaction occurs.

What happens after I get my results?

Your result will show up in your account as either positive or negative for the HLA-B*58:01 gene variant, with a plain-language explanation of what that means. If you test positive, the next step is avoiding allopurinol and discussing alternative gout medications before starting any new treatment. A downloadable lab report is available in your account for your records, and since this is a one-time genetic result, there's no need to retrack it over time like other biomarkers.

How can I naturally support healthy uric acid levels?

While this test doesn't measure uric acid itself, if you have gout or high uric acid, some everyday habits can help: cutting back on alcohol, sugary drinks, and high-purine foods like organ meats and shellfish, staying well hydrated, and maintaining a healthy weight. Cherries and vitamin C-rich foods have also been linked to lower uric acid levels in some studies. These lifestyle steps work alongside medication decisions, not as a replacement for them.

When will I get my results?

Results from this genetic test are typically ready within about 7 days of your sample being processed at the lab. You'll receive a notification once your results are posted to your secure online account. Because this is a specialized genetic test, it takes a bit longer than routine bloodwork, so plan accordingly if you're starting a new medication soon.

Who should consider this test?

This test is especially relevant for anyone being considered for allopurinol treatment, particularly if you have gout, high uric acid, or chronic kidney disease. It's most strongly recommended for people of Han Chinese, Thai, or Korean descent, since the gene variant is more common in these populations, but anyone starting allopurinol can benefit from knowing their status. Testing beforehand is a simple way to lower the risk of a severe drug reaction.

What symptoms indicate I may need this test?

You don't need current symptoms to consider this test — it's meant to be done before starting allopurinol, not after a reaction. That said, if you've ever had a severe skin rash, blistering, or peeling after starting a new medication in the past, it's worth mentioning this history and getting tested before trying allopurinol. Early signs of a reaction to watch for after starting any new drug include fever, rash, and mouth sores, which warrant seeking medical care right away.

What does a positive result mean?

A positive result means you carry the HLA-B*58:01 gene variant, which puts you at significantly higher risk of developing a severe skin reaction if you take allopurinol. This doesn't mean you will definitely have a reaction, but the risk is high enough that guidelines recommend avoiding this specific medication. Your results report will explain alternative treatment options to discuss before starting gout therapy.

What does a negative result mean?

A negative result means you don't carry the HLA-B*58:01 variant, so your risk of this specific severe reaction to allopurinol is much lower. This is generally reassuring news if allopurinol is being considered for your gout or uric acid management. Keep in mind this test only checks for one specific genetic risk, so any new medication should still be started with normal caution and awareness of general side effects.

How often should I retest?

This is a one-time test — your HLA-B*58:01 status is part of your genetic makeup and doesn't change over time, so there's no need to repeat this test later. Once you have your result, you can refer back to it any time allopurinol or a similar medication is being considered in the future. Just keep a copy of your report handy for future reference.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

HLA-B*58:01 Typing - Allopurinol Reaction Risk Test

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]