What's this test for?

This test is ideal if you're preparing for an organ or tissue transplant, or if you've already had one and need to check for immune rejection risk. It looks for antibodies in your blood that could attack donor tissue, which is especially important before a kidney, heart, or other organ transplant. It's also used if you've had a previous transplant, blood transfusion, or pregnancy, since these can trigger antibody development.

What happens after I get my results?

Your results will show up in your account with a clear explanation of what a normal versus a positive antibody finding looks like. If antibodies are detected, the report will explain the specific antibody patterns found so this information can guide next steps around transplant planning or matching. You can download a standard lab report anytime from your account, and if you're retested in the future, our trends feature lets you compare results side by side over time.

Who should consider this test?

Anyone on a transplant waiting list, anyone being evaluated as a potential organ donor, or anyone who has already received a transplant and needs ongoing monitoring should consider this test. It's also relevant if you've had multiple pregnancies, blood transfusions, or previous transplants, since these experiences can raise your chances of developing these antibodies. Testing helps identify potential compatibility issues before they become a problem.

What symptoms indicate I may need this test?

This test isn't typically ordered because of symptoms you feel day-to-day — it's more about transplant planning and monitoring. However, if you're experiencing signs of organ rejection after a transplant, such as unexplained fatigue, swelling, reduced organ function, or fever, this test can help identify if antibodies are playing a role. Your transplant team's guidance will usually be what prompts this test rather than symptoms alone.

When will I get my results?

Results are typically ready within about 7 days of your blood draw. This test involves specialized lab analysis, so it takes a bit longer than routine bloodwork. You'll get a notification as soon as your results are posted to your account.

What is HLA antibody testing and why does it matter?

HLA stands for human leukocyte antigen — these are markers on your cells that your immune system uses to tell the difference between your own tissue and foreign tissue. Class II HLA antibodies specifically target markers found on certain immune cells and are important in determining whether your body might reject a transplanted organ. Identifying these antibodies ahead of time helps match you with the most compatible donor and lowers the chance of rejection.

What does a positive HLA Class II antibody result mean?

A positive result means your immune system has developed antibodies that could react against donor tissue carrying matching markers, raising the risk of rejection if that tissue is transplanted into you. The report will detail which specific antibody types were found, which helps with donor matching. This information is typically used to guide transplant compatibility decisions and may mean certain donors are less suitable for you.

What causes someone to develop HLA Class II antibodies?

These antibodies commonly develop after exposure to foreign tissue, which can happen through pregnancy, blood transfusions, or a previous organ transplant. Each of these events exposes your immune system to markers that aren't your own, prompting an antibody response. The more exposures you've had, the more likely you are to have developed these antibodies.

How often should I retest?

If you're on a transplant waiting list, retesting is often done periodically since antibody levels can change over time, especially after new exposures like transfusions. If you've already had a transplant, ongoing monitoring at intervals recommended by your transplant program helps catch rejection risk early. Ask your transplant coordinator about the specific retesting schedule that fits your situation.

What should I do if my results are abnormal?

If antibodies are detected, don't panic — this is common and manageable information used in transplant planning rather than a diagnosis on its own. Share your results promptly with your transplant program so they can factor this into donor matching decisions. If you're experiencing symptoms of rejection after a transplant, such as fever, pain, or reduced organ function, seek medical care right away.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

HLA Class II Antibody Test - Transplant Compatibility

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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