What's this test for?

This test is ideal if you're experiencing dry, scaly skin patches that started in infancy or early childhood, especially if you're male, since this condition mainly affects boys and men. It's also useful if there's a family history of ichthyosis or if a genetic counselor has suggested checking for a steroid sulfatase gene deletion. Many people use this test to get a clear genetic answer after noticing persistent scaling skin that doesn't improve with regular moisturizers.

What's included in this test?

This test looks specifically at the STS gene region using a technique called FISH, which checks for a missing piece of genetic material tied to steroid sulfatase deficiency. This single, targeted analysis is designed to confirm or rule out the genetic cause behind X-linked ichthyosis symptoms rather than screening broadly like a panel would.

What happens after I get my results?

Your results will show up in your online account along with a clear explanation of what a normal versus abnormal finding means for this specific genetic marker. If your result shows a deletion linked to steroid sulfatase deficiency, the report will explain what that means and what practical next steps look like, such as skin care routines or additional family testing. You can download a standard lab report anytime from your account, and if you ever retest in the future, you can track results side by side using the trends feature.

How can I naturally support healthy skin with ichthyosis?

While this test identifies a genetic cause, daily skin care makes a real difference in comfort. Using thick, fragrance-free moisturizers right after bathing, taking shorter lukewarm showers, and adding a humidifier at home can all help reduce scaling and dryness. Gentle exfoliation with products containing urea or lactic acid is also commonly used to soften rough patches.

When will I get my results?

Results for this test are typically ready within about 7 days of your sample being processed at the lab. Because this is a specialized genetic test, it takes a bit longer than routine bloodwork, so you'll want to plan accordingly. You'll get a notification as soon as your results are posted to your account.

Who should consider this test?

This test is a good fit for males with lifelong dry, scaly skin, especially scaling on the neck, trunk, or limbs that started in early childhood. It's also worth considering if a close relative has been diagnosed with X-linked ichthyosis or steroid sulfatase deficiency, since this condition runs in families. Anyone seeking a definitive genetic explanation before starting a long-term skin care plan may also find this test helpful.

What symptoms indicate I may need this test?

Common signs include dry, scaly skin that looks like fine fish scales, particularly on the arms, legs, and torso, that tends to worsen in cold, dry weather. Some people also notice the scaling has been present since infancy and doesn't respond well to typical lotions. In some cases, corneal opacities (cloudy spots on the eye) can also occur, so mentioning any eye changes is worth noting too.

What is steroid sulfatase deficiency and why does it matter?

Steroid sulfatase deficiency happens when a gene on the X chromosome is missing or not working properly, which affects an enzyme needed for normal skin shedding. Without enough of this enzyme, skin cells build up instead of shedding normally, leading to the dry, scaly patches seen in X-linked ichthyosis. Knowing you have this deficiency helps explain lifelong skin symptoms and can guide family planning conversations since it's passed down genetically.

What causes this genetic deletion?

The deletion is typically inherited from a mother who carries one altered copy of the gene, since the condition is passed down on the X chromosome. It's not caused by diet, environment, or lifestyle choices. Because it's inherited, other family members, especially male relatives on the mother's side, may want to consider testing as well.

What should I do if my results come back positive?

If your result confirms the gene deletion, the most useful next step is focusing on a consistent daily skin care routine using thick moisturizers and gentle exfoliants to manage scaling. It's also worth sharing the result with close family members since they may want to get tested too, given the inherited nature of this condition. If you notice any sudden vision changes or severe skin symptoms, seek medical care promptly.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

X-Linked Ichthyosis Test - Steroid Sulfatase Gene Check

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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