What's this test for?

This test is ideal if you or a loved one has been diagnosed with non-small cell lung cancer, specifically lung adenocarcinoma, and your care plan requires more detail about the tumor's genetic makeup. It looks for a specific gene rearrangement called RET that shows up in a small percentage of these tumors, more often in younger patients. Knowing whether this rearrangement is present can help guide which treatment options may work best for the specific tumor.

What's included in this test?

This test uses a specialized dual-color FISH probe mixture that examines tumor tissue samples for a break-apart pattern in the RET gene. This matters because RET rearrangements act as a switch that can drive cancer cell growth, so detecting them can point toward specific targeted treatment approaches. The test is performed on preserved tumor tissue rather than a blood draw.

What happens after I get my results?

Your results will appear in your account along with an explanation of what a positive or negative RET rearrangement finding means. If the rearrangement is detected, the next step is usually discussing targeted therapy options that specifically address RET-driven tumors. A downloadable copy of the standard lab report is always available in your account, and you can revisit your results anytime through the trends feature to keep a record for future reference.

How can I naturally support lung and immune health during cancer testing?

While no natural remedy can replace targeted cancer testing or treatment, some everyday habits can support your body during this process. Eating a nutrient-dense diet with plenty of vegetables, fruits, and lean protein helps maintain strength and energy. Staying physically active as tolerated, avoiding tobacco smoke, getting enough sleep, and managing stress through relaxation techniques can also support your overall well-being alongside your treatment plan.

When will I get my results?

Results for this test are typically ready within about 7 days after your tumor sample is processed at the lab. FISH testing requires careful lab preparation of the tissue sample, which is why it takes a bit longer than a standard blood test. You'll receive a notification as soon as your results are posted to your account.

Who should consider this test?

This test is most relevant for people already diagnosed with lung adenocarcinoma, particularly younger patients or those without a heavy smoking history, since RET rearrangements are more commonly found in this group. It's also useful for anyone whose tumor genetic profile is being built out to guide treatment decisions. This is a good next step when standard treatments haven't been effective or when a more precise, personalized treatment approach is being explored.

What symptoms indicate I may need this test?

Since this test looks at tumor tissue rather than screening for cancer from scratch, it's typically ordered after a lung adenocarcinoma diagnosis rather than based on symptoms alone. That said, symptoms that originally led to a lung cancer diagnosis often include a persistent cough, unexplained weight loss, chest pain, and shortness of breath. If you're already navigating a lung cancer diagnosis, this test adds detail to what's already been found, rather than screening for new symptoms.

What is a RET gene rearrangement and why does it matter?

A RET gene rearrangement happens when a piece of the RET gene breaks off and fuses with another gene, creating an abnormal signal that can push cells to grow and divide uncontrollably. In lung adenocarcinoma, this rearrangement shows up in about 1-2% of cases, more often in younger patients. Identifying this specific change matters because there are targeted therapies designed to work directly against RET-driven tumors, offering a more precise treatment path than standard chemotherapy alone.

What does a positive RET rearrangement result mean?

A positive result means the FISH test detected the RET gene rearrangement in the tumor sample, confirming that this specific genetic change is driving the cancer's growth. This finding is actionable because it opens the door to targeted therapies designed specifically for RET-altered tumors, which often work better and cause fewer side effects than general chemotherapy. Discussing this result as part of your broader treatment plan is an important next step.

How often should I retest for this rearrangement?

Typically, RET rearrangement testing is done once at diagnosis or when treatment decisions are being reconsidered, rather than on a regular retesting schedule. If your tumor changes or stops responding to a targeted therapy, retesting a new tissue sample may be recommended to check whether the tumor's genetic profile has shifted. Your treatment timeline and any new symptoms should guide whether repeat testing makes sense.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

RET FISH Test - Lung Adenocarcinoma Tumor Analysis

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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