What's this test for?

This test is ideal if you've been diagnosed with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) and need more information about how your condition may behave over time. It helps identify a specific genetic change - deletion of part of chromosome 17 - that can affect how well certain treatments work. This test is typically used as part of an ongoing leukemia or lymphoma workup, not as a general screening test for the public.

What's included in this test?

This is a single, targeted genetic test rather than a multi-marker panel. It uses a lab technique called FISH (fluorescence in situ hybridization) to look specifically at a region of chromosome 17 where the TP53 gene sits, checking whether a piece of it is missing. This matters because loss of this gene region is linked to more difficult-to-treat forms of CLL/SLL, making it one of the most important genetic findings in this disease.

What happens after I get my results?

Your results will appear in your secure online account, with an explanation of what a positive or negative finding means for this specific genetic marker. Because this is a specialized genetic test tied to an existing CLL/SLL diagnosis, next steps typically involve discussing timing of treatment or retesting at disease progression, especially if no TP53 abnormality was found initially. You can download the full lab report from your account at any time, and if you're tracking this alongside other lab work, the trends feature lets you keep a record of results over time. If your results indicate an unfavorable finding, it's important to seek follow-up care promptly to discuss treatment planning.

How can I naturally support my immune and blood health?

While no lifestyle change can reverse a genetic deletion, supporting your overall immune and blood health can help your body handle treatment better. Eating a balanced diet rich in fruits, vegetables, and lean protein, staying well hydrated, getting regular gentle exercise, and prioritizing sleep all help support your immune system. Avoiding infections by practicing good hygiene and limiting exposure to sick contacts is especially important if your white blood cell function is affected by CLL/SLL.

When will I get my results?

Results for this test are typically available within about 7 days after your sample is processed at the lab. FISH testing requires specialized lab handling since it involves examining chromosomes directly under a microscope, which takes a bit longer than routine blood work. You'll receive an email notification as soon as your results are ready to view in your account.

Who should consider this test?

This test is meant for people who already have a confirmed or suspected diagnosis of CLL/SLL and need genetic information to help guide prognosis and treatment decisions. It's also relevant for patients whose CLL/SLL has progressed and who haven't previously been tested for TP53 abnormalities. This is not a general wellness or screening test for people without a lymphoid cancer diagnosis.

What symptoms indicate I may need this test?

If you've already been diagnosed with CLL/SLL, your care plan may call for this test regardless of symptoms, since it's about genetics rather than day-to-day symptoms. That said, signs like swollen lymph nodes, unexplained fatigue, frequent infections, easy bruising, or unintended weight loss are often what led to the original CLL/SLL diagnosis. If you're experiencing these symptoms without a prior diagnosis, the first step is usually a complete blood count and clinical evaluation, not this specific genetic test.

What is TP53 deletion and why does it matter?

TP53 is a gene that normally helps control cell growth and stops damaged cells from multiplying out of control, earning it the nickname "guardian of the genome." When part of chromosome 17 that holds this gene is deleted, that protective function is lost, which can allow cancer cells to grow more aggressively and resist standard treatments. This is why detecting a 17p13.1 deletion is considered one of the strongest predictors of how CLL/SLL will respond to therapy.

What does a positive result for this deletion mean?

A positive result means that a portion of chromosome 17, including the TP53 gene, is missing in some or all of the tested cells. This finding is linked to a less favorable prognosis and often means that standard chemotherapy-based treatments may not work as well, so alternative treatment approaches are usually considered. It's important to discuss this result promptly since it can directly change the treatment plan.

How often should I retest for this genetic marker?

If your initial test comes back negative, current guidance recommends retesting at the point of disease progression, since this genetic change can develop after treatment even if it wasn't present at diagnosis. There's no need to routinely retest if your CLL/SLL remains stable and previous results were already positive, since the deletion doesn't reverse itself. Your overall treatment timeline will typically guide how often this and related genetic tests are repeated.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

TP53 Deletion Test - CLL/SLL Prognosis & Treatment

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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