What's this test for?

This test is ideal if you're being followed for a myeloid blood disorder, such as acute myeloid leukemia or myelodysplastic syndrome, and your care needs information about a specific chromosome change. It looks for a rearrangement in the MECOM (EVI1) gene region on chromosome 3, which is linked to more aggressive disease behavior. This helps clarify what's happening at the genetic level so you and your care team can better understand your condition.

What happens after I get my results?

Your results will show up in your account with an explanation of what a positive or negative finding means for this specific gene rearrangement. If the rearrangement is found, the report will explain why this matters for tracking your condition, and you can discuss next steps with your care team as part of your ongoing treatment plan. You can download a standard lab report from your account at any time, and if you're retested in the future, the trends feature lets you compare results side by side.

Who should consider this test?

This test is meant for people already diagnosed with or being evaluated for a myeloid neoplasm, like acute myeloid leukemia or myelodysplastic syndrome, where genetic information helps guide understanding of the disease. It's also useful for people whose blood cell counts show signs consistent with megakaryocyte dysplasia, a pattern sometimes linked to this specific gene change. It is not a general screening test for people without a myeloid condition.

What symptoms indicate I may need this test?

Symptoms alone don't usually point specifically to a MECOM (EVI1) rearrangement — this test is typically ordered based on findings from a bone marrow biopsy or blood work showing abnormal cell development. That said, symptoms like unusual fatigue, easy bruising or bleeding, frequent infections, or unexplained weight loss can be signs of an underlying myeloid disorder worth investigating. If you're already being monitored for a blood cancer and your counts or biopsy results have changed, this test may be recommended to look deeper at the genetic picture.

When will I get my results?

Results for this test typically take about 7 days to process, since it involves detailed genetic analysis of chromosome samples in the lab. You'll receive a notification and can log into your account to view the full report once it's ready. If your situation feels urgent, don't wait on this test alone — reach out for care right away if you're having severe symptoms.

What is MECOM (EVI1) and why does it matter?

MECOM, also called EVI1, is a gene located on chromosome 3 that normally helps control how blood-forming cells grow and mature. When this gene gets rearranged or disrupted, it can interfere with how myeloid cells (a type of blood cell) develop, sometimes leading to more aggressive forms of blood cancer. Finding this rearrangement gives helpful information about how a myeloid condition may behave over time.

What does a positive result mean?

A positive result means the lab found a rearrangement involving the MECOM (EVI1) gene region, often from chromosome changes like inv(3), t(3;3), t(3;21), or t(3;12). This finding is generally associated with a more difficult-to-treat form of myeloid disease and may affect how your condition is tracked going forward. It doesn't determine everything about your outlook, but it's an important piece of the bigger picture your care plan is built around.

What causes this chromosome rearrangement?

These rearrangements happen when pieces of chromosome 3 break and reattach in the wrong place, disrupting the normal MECOM (EVI1) gene. This is not something caused by lifestyle or diet — it's a genetic change that occurs within abnormal blood-forming cells, most often seen in myeloid blast crisis or as leukemia progresses. Researchers still don't fully know why certain cells develop these specific rearrangements.

How often should I retest?

Retesting frequency depends on your individual treatment and monitoring plan, and it's common to repeat this type of genetic testing at key points, such as after starting a new treatment or if blood counts change significantly. Many people are retested every few months during active treatment monitoring, then less often once things stabilize. Use the trends feature in your account to keep track of results over time and spot any changes early.

What should I do if my results are abnormal?

If your result shows a MECOM (EVI1) rearrangement, the report will walk you through what that finding means in plain language. This information is meant to be shared with your ongoing care plan, since it may influence treatment decisions or how closely your condition is monitored. If you experience severe symptoms like heavy bleeding, high fever, or extreme fatigue, seek medical care right away rather than waiting.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

MECOM (EVI1) FISH Test - Myeloid Cancer Gene Screening

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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