What's this test for?

This test is ideal if you're being evaluated for a B-cell lymphoma, chronic lymphocytic leukemia, plasma cell myeloma, or acute lymphoblastic leukemia and your care team needs more detail about the genetic makeup of the abnormal cells. It looks for a specific chromosome rearrangement that can help clarify a diagnosis that other testing left uncertain. It's typically used as a follow-up test rather than a first-line screening test.

What's included in this test?

This is a single, targeted test rather than a panel of separate biomarkers. It uses a break-apart FISH probe to look specifically at the IGL (immunoglobulin lambda light chain) gene region on chromosome 22 to see if it has become rearranged, which can happen in certain blood cancers.

What happens after I get my results?

Your results will be posted to your account along with an explanation of what a normal (negative) versus abnormal (positive) finding means for this specific probe. Because this is a specialized cytogenetic test tied to an existing diagnosis or workup, next steps usually involve discussing the finding in the context of your other lab and pathology results rather than routine lifestyle changes. A downloadable standard lab report is available in your account, and if you have repeat testing done over time you can track results using the trends feature. If your result indicates a translocation, treat it as important information to bring into your ongoing evaluation right away.

When will I get my results?

Results for this specialized cytogenetic test are typically available within about 7 days. FISH testing requires careful lab processing of cell samples, which is why the turnaround is longer than a standard blood test. You'll be notified as soon as your results are ready to view in your account.

Who should consider this test?

This test is generally considered for people who already have a suspected or confirmed blood cancer diagnosis, such as a lymphoma, leukemia, or plasma cell myeloma, where more detailed genetic information is needed. It's also useful when other testing found a rearrangement involving the IGH gene region but couldn't fully characterize it. This is a specialized, targeted test rather than a general wellness or screening test for the public.

What symptoms indicate I may need this test?

This test isn't typically ordered based on everyday symptoms alone. It's more commonly used after signs like unexplained swollen lymph nodes, persistent fatigue, unexplained weight loss, or abnormal blood counts have already led to a suspected diagnosis of a blood-related cancer. If you're experiencing these symptoms, they usually prompt other initial tests first, with FISH testing like this one used to add detail afterward.

What is a gene translocation and why does it matter?

A gene translocation happens when a piece of one chromosome breaks off and attaches to a different chromosome, which can disrupt how nearby genes work. In some blood cancers, translocations involving immunoglobulin gene regions like IGL can turn on cancer-related genes or turn off protective ones. Identifying these translocations helps characterize the specific subtype of disease, which can be useful for understanding how it may behave.

What does a positive result mean?

A positive result means the FISH probe detected a break or rearrangement in the IGL gene region, which is seen in certain B-cell blood cancers. This finding is usually interpreted together with your other test results, biopsy findings, and clinical history rather than on its own. It does not diagnose a condition by itself but adds an important piece to the overall picture.

How often should I retest?

This is not a routine test you would repeat on a regular schedule like an annual screening. Retesting is generally only relevant if there's a new clinical concern, a change in disease status, or if it's specifically part of an ongoing evaluation. Follow the guidance provided with your original testing plan for whether or when repeat testing makes sense.

What should I do if my results are abnormal?

If your result comes back positive, keep a copy of the downloadable report and make sure it's included with your other lab and pathology records for your ongoing evaluation. This finding is meant to be reviewed alongside your full clinical picture, not interpreted alone. If you have concerning symptoms alongside an abnormal result, don't wait — seek medical care promptly.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

IGL FISH Test - Blood Cancer Gene Rearrangement Check

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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