What's this test for?

This test is ideal if you're experiencing unexplained high eosinophil counts (a type of white blood cell) found on a routine blood count, or if you've been told you may have an eosinophilia-associated blood disorder. It looks for a specific genetic change linked to certain rare blood conditions that can respond very well to targeted treatment. It's often used to help understand the cause of persistently elevated eosinophils when other explanations have been ruled out.

What's included in this test?

This test uses a technique called FISH (fluorescence in situ hybridization) to look at your chromosomes for a specific structural change near a region called 4q12. This category of testing matters because detecting this particular genetic rearrangement can identify people who are likely to respond exceptionally well to a specific class of medication, which changes how a case might be managed.

What happens after I get my results?

Your results will be available in your account along with an explanation of what a positive or negative finding means. If the rearrangement is detected, the report will explain that this finding is associated with a strong response to a specific targeted therapy, and next steps typically involve prompt follow-up given the actionable nature of this result. You can download a standard lab report directly from your account at any time, and if repeat testing is ever needed, you can track results over time using the trends feature.

Who should consider this test?

This test is typically considered for people who have unexplained, persistently high eosinophil counts on blood work, especially when a hematologic disorder is suspected. It can also be relevant for people being evaluated for rare eosinophilia-associated conditions where identifying the exact genetic driver matters for choosing an effective approach. If you've had abnormal white blood cell patterns flagged repeatedly, this test can help clarify the underlying cause.

What symptoms indicate I may need this test?

Common signs that prompt this kind of testing include fatigue, unexplained rashes, shortness of breath, or organ-related symptoms that occur alongside a high eosinophil count on standard blood work. Some people have no obvious symptoms at all and are flagged only because of abnormal lab results. If you've had repeated elevated eosinophil levels without a clear explanation like allergies or parasitic infection, this test may be a helpful next step.

What is the FIP1L1-PDGFRA rearrangement and why does it matter?

This is a specific genetic change where two genes on chromosome 4 fuse together, creating an abnormal protein that can drive uncontrolled growth of certain white blood cells. It matters because this particular fusion is strongly associated with a favorable response to a well-studied targeted medication, meaning identifying it can directly shape the approach to managing the condition. Without this test, it can be hard to tell apart different causes of eosinophilia that look similar on standard blood work.

What does a positive result mean?

A positive result means the FIP1L1-PDGFRA gene rearrangement was detected in your sample, which is associated with certain eosinophilia-related blood disorders. This is considered an important and actionable finding, since cases with this rearrangement often respond very well to targeted treatment. Because of the significance of a positive result, prompt follow-up is recommended rather than waiting for routine reassessment.

What does a negative result mean?

A negative result means this specific genetic rearrangement was not found in your sample, which makes this particular cause of eosinophilia less likely. It doesn't rule out other causes of elevated eosinophils, so if your counts remain high, further evaluation of other potential causes may still be worthwhile. Tracking your eosinophil levels over time can help show whether the pattern is changing.

How often should I retest?

This is typically a one-time test used to investigate a specific finding rather than something retested on a regular schedule. If your initial eosinophil counts change significantly or new symptoms develop, retesting or additional follow-up testing may be worth considering. Use the trends feature in your account to keep an eye on related blood count values over time.

What should I do if my results are abnormal?

If your result is positive, review the detailed report explanation in your account, since this finding is generally considered significant and warrants prompt attention. If you experience severe symptoms such as significant shortness of breath, chest pain, or sudden swelling, seek medical care right away rather than waiting. For non-urgent follow-up, use your results and report to guide next steps in managing the finding.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

FIP1L1-PDGFRA FISH Test - Eosinophilia Gene Screening

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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