What's this test for?

This test is ideal if you're already diagnosed with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) and need more information about how your condition may behave over time. It looks for an extra copy of chromosome 12 (trisomy 12), one of the most common genetic changes seen in CLL/SLL. This information helps piece together a fuller picture of your condition alongside your other clinical findings.

What's included in this test?

This test uses a technique called FISH (fluorescence in situ hybridization) to look specifically for an extra copy of chromosome 12 in blood cells. This particular genetic change is checked because it's one of the four most common abnormalities found in CLL/SLL and helps place a case into a general risk category. It's a targeted, single-marker test rather than a broad panel.

What happens after I get my results?

Your results will be available in your account, with an explanation of what a positive or negative finding for trisomy 12 means. Because this is a specialized genetic test tied to an existing diagnosis, next steps usually involve discussing the finding within the context of your full clinical picture and any other genetic tests you've had done, rather than acting on this result alone. A standard lab report is available for download from your account at any time, and you can track this and other results over time using the trends feature. If your results indicate a genetic abnormality alongside worsening symptoms like severe fatigue or swollen lymph nodes, seek medical care promptly.

Who should consider this test?

This test is best suited for people who already have a confirmed or suspected diagnosis of CLL/SLL and are working through genetic risk classification. It's typically used as a follow-up test rather than a first-line screening tool for the general population. If you've been told you have CLL/SLL and haven't had genetic testing yet, this is one of the tests commonly used to learn more about your specific case.

When will I get my results?

Results for this test are typically available within about 7 days of your blood sample being processed at the lab. FISH testing requires specialized lab analysis, which is why it takes a bit longer than a standard blood panel. You'll be notified as soon as your results are ready to view in your account.

What symptoms indicate I may need this test?

Symptoms that often lead to this kind of genetic testing include persistently swollen lymph nodes, unexplained fatigue, unintentional weight loss, night sweats, or a previously identified high white blood cell count. These symptoms alone don't mean you have CLL/SLL, but if you've already received that diagnosis, this test helps characterize it further. If you're experiencing these symptoms without a prior diagnosis, a broader blood workup is usually the first step.

What is trisomy 12 and why does it matter?

Trisomy 12 means a cell has three copies of chromosome 12 instead of the usual two. It shows up in about 16% of people with CLL/SLL and is linked with an intermediate prognostic risk category, meaning it's not the most favorable or the most concerning genetic finding. Knowing whether you have this change helps build a more complete understanding of how your condition may progress.

What does a positive result for trisomy 12 mean?

A positive result means the extra copy of chromosome 12 was detected in your tested cells, which places your case into an intermediate-risk category among CLL/SLL genetic findings. This is one piece of a larger puzzle and doesn't determine your outlook on its own. It's typically considered together with other genetic markers like del(13q), del(11q), and del(17p) to get a full risk picture.

How often should I retest?

Genetic markers like trisomy 12 don't typically change over the course of the disease the way a blood count might, so this test isn't usually repeated on a regular schedule. Retesting may be considered if your condition changes significantly or if new treatment decisions require updated genetic information. Because retest timing depends heavily on individual circumstances, use your latest clinical picture to decide if and when repeat testing makes sense.

What should I do if my results are abnormal?

If trisomy 12 is detected, keep this result together with your other CLL/SLL test findings, since it's meant to be interpreted alongside your broader clinical history and any other genetic results. Focus on habits that support your overall health, such as staying on top of routine checkups, eating a balanced diet, and getting adequate rest, since these support your body during any condition. If you notice new or worsening symptoms like fevers, drenching night sweats, or rapidly growing lymph nodes, seek medical care right away.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

FISH Trisomy 12 Test - CLL Genetic Risk Panel

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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