What's this test for?

This test is ideal if you're already diagnosed with chronic lymphocytic leukemia (CLL) or a related B-cell lymphoproliferative disorder and need more information about how your disease might behave. It helps identify specific genetic changes in your cells that are linked to how aggressive the condition may be and how well certain treatments might work. This is typically used alongside other CLL testing to help guide treatment planning.

What's included in this test?

This test looks specifically for deletions in two genes, ATM and TP53, using a technique called FISH (fluorescence in situ hybridization) that detects missing pieces of genetic material inside cells. These two genes matter because their loss is strongly linked to how CLL and similar conditions progress and respond to treatment. Checking them separately (instead of the full CLL FISH panel) gives focused information when that's all that's needed.

What happens after I get my results?

Your results will be available in your account, with each finding explained so you understand what was detected. Because this test looks at genetic deletions tied to disease behavior, the report will note whether ATM or TP53 deletions were found and what that generally means for disease outlook. If a deletion is found, discussing targeted treatment options and closer monitoring is a reasonable next step, and retesting may be recommended later to track any changes. You can download the full lab report anytime and use the trends feature to keep a record over time.

Who should consider this test?

People already diagnosed with CLL, SLL, or another B-cell lymphoproliferative disorder who need prognostic information are the main candidates for this test. It's also useful for those who have already had a broader CLL FISH panel but need updated or repeat testing on just these two markers. This is not a general screening test for people without a prior diagnosis.

What symptoms indicate I may need this test?

This test isn't based on new symptoms but on an existing diagnosis of CLL or a similar blood cancer. That said, signs like swollen lymph nodes, rapid disease progression, or a change in how you're responding to treatment are reasons your testing team might want this genetic information. Marked lymphadenopathy in particular has been linked to one of these deletions.

What is a TP53 or ATM deletion and why does it matter?

TP53 and ATM are genes that normally help control cell growth and repair damaged DNA. When part of one of these genes is missing (deleted), cells can grow and survive in ways that are harder to treat with standard chemotherapy. Knowing whether these deletions are present helps explain why some CLL cases behave more aggressively or respond differently to treatment than others.

What does a TP53 deletion mean for treatment?

A TP53 deletion is linked to a lower chance that standard chemotherapy drugs like alkylating agents or fludarabine will work well. It's also linked to shorter survival times compared to CLL without this deletion. Because of this, targeted therapies (rather than traditional chemotherapy) are usually considered a better option when this deletion is present.

What does an ATM deletion mean for my outlook?

An ATM deletion is associated with more noticeable lymph node swelling, faster disease progression, and a less favorable overall outlook compared to CLL without this change. It gives independent information beyond TP53 status, meaning both deletions can add separate pieces to the overall picture. This information is typically used to help shape how closely your condition should be monitored.

How often should I retest?

Retesting frequency depends on your individual disease course and whether your treatment changes, since these genetic deletions can be reassessed if your condition progresses or stops responding to therapy. Many people retest when starting a new treatment line or if there's a notable change in symptoms. There's no fixed schedule that applies to everyone, so timing should be based on your specific situation.

What should I do if my results show a deletion?

If a deletion is found, it's a good idea to discuss targeted therapy options, since these deletions are linked to weaker responses to standard chemotherapy. Keeping close track of symptoms like lymph node swelling and reporting any rapid changes is also important. Using the trends feature to compare this result with any future FISH testing can help track how your condition evolves over time.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

ATM & TP53 FISH Test - CLL Prognosis & Treatment Guide

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]