What's this test for?

This test is ideal if you're being evaluated for acute myeloid leukemia (AML) or if you already have an AML diagnosis and need more detail about the specific type. It looks for a chromosome change called inversion 16 (or a related translocation t(16;16)) that affects a gene pairing called CBFB-MYH11. This information helps clarify what subtype of AML may be present, which can be important for understanding the condition.

What's included in this test?

This test uses a specialized lab technique called FISH (fluorescence in situ hybridization) to look directly at chromosomes in a blood or bone marrow sample. It specifically checks for a rearrangement between two genes, CBFB and MYH11, which happens when part of chromosome 16 flips or swaps in a way that can drive abnormal cell growth. Finding this exact genetic change matters because it points to a specific, well-studied form of AML.

What happens after I get my results?

Your results will be available in your secure online account, with an explanation of what a positive or negative finding means for this specific genetic marker. Because this is a specialized diagnostic test tied to a serious condition, any positive result should prompt immediate follow-up care to discuss next steps, while a negative result may still warrant further blood work depending on your symptoms. You can download a standard lab report from your account at any time, and if repeat testing is ever needed, you'll be able to track results over time using the trends feature.

How should I naturally support healthy blood cell function?

While a genetic finding like this can't be changed through lifestyle, supporting your overall health can help your body handle treatment and recovery better. Eating a balanced diet rich in protein, iron, and vitamins, staying well hydrated, and getting enough rest can support your energy and immune function. Avoiding infections by practicing good hygiene and avoiding crowded sick environments is also important when blood cell counts may be affected. Always prioritize any urgent symptoms like fever, unusual bruising, or extreme fatigue by seeking medical care right away.

When will I get my results?

Results for this test are typically available within about 7 days after your sample is processed at the lab. This slightly longer timeframe reflects the specialized FISH technique needed to closely examine chromosome structure. You'll receive a notification as soon as your results are ready to view in your account.

Who should consider this test?

This test is most relevant for people already showing signs of a blood disorder, such as unexplained fatigue, easy bruising or bleeding, frequent infections, or abnormal results on a routine complete blood count. It's also useful for people already diagnosed with AML who need more specific information about their leukemia subtype. This is a specialized diagnostic tool rather than a general wellness or screening test.

What symptoms indicate I may need this test?

Symptoms that might lead to this type of testing include ongoing fatigue, pale skin, unexplained fevers, frequent infections, easy bruising or bleeding, and bone or joint pain. These symptoms can sometimes point to problems with blood cell production. If you're experiencing several of these symptoms together, especially if they're severe or getting worse, it's important to seek medical care promptly.

What is inversion 16 and why does it matter?

Inversion 16 is a specific change in chromosome 16 where a section of the chromosome flips around and joins two genes, CBFB and MYH11, that normally aren't connected. This abnormal gene pairing can interfere with how blood cells mature, contributing to acute myeloid leukemia. Identifying this specific change matters because it's linked to a particular AML subtype with its own expected course and treatment considerations.

What does a positive result mean?

A positive result means the lab detected the CBFB-MYH11 gene rearrangement, confirming the presence of inversion 16 or the related translocation t(16;16). This finding supports a diagnosis of a specific subtype of acute myeloid leukemia. Because this is a significant finding, prompt follow-up and further evaluation are strongly recommended.

What should I do if my results are abnormal?

If your result comes back positive, it's important to seek follow-up care as soon as possible to discuss what this genetic finding means for your specific situation. Bring your downloadable lab report with you, as it clearly documents the finding and can help guide further evaluation. Don't wait on scheduling next steps, since timely action is especially important with any AML-related result.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

AML Inversion 16 Test - CBFB/MYH11 FISH Analysis

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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