What's this test for?

This test is ideal if you're concerned about your risk of blood clots, especially if blood clots or clotting disorders run in your family. It looks at a specific gene change (called Factor XIII Val34Leu) that can influence how your blood clots and how stable those clots are. Many people take this test to better understand their genetic risk before starting hormone therapy, surgery, long travel, or pregnancy planning.

What's included in this test?

This test looks specifically at one genetic marker related to how your blood clots, rather than a panel of many biomarkers. Understanding this single variant matters because it can shift how efficiently your clotting protein works, which in turn affects clot structure and stability. Knowing your status can add helpful context to your overall clotting risk profile.

What happens after I get my results?

Your results will show up in your account along with an explanation of what your specific gene variant means. Since this is a one-time genetic result, there's usually no need to retest, but the report will explain whether your variant is associated with a protective effect or a different clotting pattern. You can download the full lab report from your account at any time, and it stays saved in your trends history for future reference. If you have other risk factors for clotting, this result can help guide conversations about lifestyle changes like staying active during long trips or managing weight.

Who should consider this test?

This test is a good fit for people with a family history of blood clots (deep vein thrombosis or pulmonary embolism), those planning to start hormonal birth control or hormone replacement therapy, and people preparing for major surgery or long periods of immobility. It can also be useful for those who've already had an unexplained clotting event and want more insight into potential genetic contributors. If you're unsure whether it applies to you, reviewing your family health history is a good first step.

What symptoms indicate I may need this test?

There aren't usually direct symptoms tied to carrying this gene variant, since it doesn't cause pain or illness on its own. However, if you or close family members have had unexplained leg swelling, calf pain, shortness of breath, or a diagnosed blood clot, that history is a strong reason to consider this test. Recurrent miscarriages have also prompted some people to look into clotting-related genetics.

How can I naturally support healthy blood clotting?

Staying physically active, avoiding long periods of sitting, and maintaining a healthy body weight all support normal blood flow and clotting balance. Staying well hydrated, especially during travel, helps keep blood from becoming too thick. Eating a balanced diet with omega-3 fatty acids (found in fish and flaxseed) has also been linked to healthier clotting patterns, though it's not a substitute for medical care when clotting risk is high.

What is Factor XIII and why does it matter?

Factor XIII is a protein in your blood that acts like a glue, helping to stabilize blood clots after they form. The Val34Leu variant is a small change in the gene that makes this protein, and it can affect how quickly and how tightly your clots hold together. Interestingly, research suggests this particular variant may have a modest protective effect against certain clotting disorders, unlike many other clotting-related gene changes.

What does carrying the Val34Leu variant mean for my clot structure?

If you carry this variant, research shows your Factor XIII protein may activate faster, which changes the fibers that make up your blood clot. The resulting clot tends to have finer, thinner fibers and smaller pores, making it structurally different from a typical clot. This has been associated with a small reduced risk of venous blood clots in study populations.

Does having or not having this variant change my clotting risk category?

Carrying one or two copies of the Leu variant has been linked to a modestly lower risk of venous thromboembolism in large studies, but it doesn't eliminate risk entirely. Not carrying the variant simply means this particular protective effect isn't present for you, not that you automatically have high risk. Your overall clotting risk still depends on many other genetic and lifestyle factors combined.

How often should I retest this?

Since this is a genetic test looking at a fixed DNA variant, your result won't change over time, so retesting isn't necessary. Your gene sequence stays the same throughout your life, unlike other blood markers that can fluctuate. You only need to take this test once, and the result remains valid for future reference.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Factor XIII Val34Leu Test - Blood Clot Risk Gene

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]

Factor XIII Val34Leu Genetic Clotting Risk Test

Factor XIII V34L Mutation Analysis

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

What's this test for?

What's included in this test?

What happens after I get my results?

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Factor XIII Val34Leu Genetic Clotting Risk Test

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

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