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Desmoglein 1 and 3 antibody test for diagnosing pemphigus skin conditions

Desmoglein Antibodies Test for Pemphigus Diagnosis

Desmoglein Antibodies (1 and 3)

  • Detect autoimmune causes of skin blistering
  • Check for recurring mouth sore triggers
  • Screen for pemphigus antibody activity
$429
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you're experiencing unexplained blistering or sores on your skin or in your mouth that won't heal properly. It looks for specific antibodies your immune system may be making against your own skin cells, which is what happens in a rare condition called pemphigus. If you have painful mouth sores, skin blisters, or peeling skin that keeps coming back, this test can help figure out what's going on.

What's included in this test?

This test checks for two specific autoantibodies your body may produce that attack proteins holding your skin cells together. Measuring both types helps distinguish between different forms of pemphigus, since each type tends to affect different areas of the body like the mouth versus the deeper layers of skin.

What happens after I get my results?

Your results will show up in your account with each value explained so you understand what's normal and what isn't. If your antibody levels come back elevated, next steps usually include seeking care to confirm a diagnosis and discuss treatment options, since blistering skin conditions can worsen without proper management. You can download a standard lab report anytime from your account, and if you retest in the future, the trends feature lets you track changes in your antibody levels over time.

How can I naturally support skin healing during a flare?
While there's no natural remedy that stops the underlying antibody activity, you can support skin healing by keeping affected areas clean and avoiding harsh soaps or friction. Eating a balanced diet with enough protein and vitamin C can help support tissue repair. Avoiding spicy, acidic, or rough-textured foods can also reduce irritation if you have mouth sores. Getting enough rest helps your body handle inflammation better overall.
When will I get my results?
Results are typically ready within about 7 days after your sample is collected. You'll get a notification once they're posted to your account, where you can view a full breakdown of what each result means.
Who should consider this test?
This test is a good fit if you have persistent, unexplained blisters or open sores on your skin or in your mouth that keep recurring or aren't healing. It's also useful if you've been told you might have an autoimmune skin condition and want lab evidence to help clarify the diagnosis. People with a family history of autoimmune conditions who develop unusual skin symptoms may also want to consider this test.
What symptoms indicate I may need this test?
Watch for painful blisters or sores in your mouth, throat, or on your skin that break open easily and are slow to heal. Other signs include skin that seems fragile and peels or blisters with minor rubbing, or crusty sores that keep coming back in the same spots. If these symptoms are widespread or getting worse, it's worth getting checked.
What does a high antibody result mean?
A high result means your immune system is likely producing antibodies that attack the proteins holding your skin cells together, which is the hallmark of pemphigus. The specific pattern, whether Desmoglein 1, 3, or both are elevated, can help indicate whether the condition is mainly affecting your skin, your mouth, or both. Higher levels are often associated with more active or widespread disease.
What causes these antibodies to become elevated?
These antibodies are produced when your immune system mistakenly targets normal skin proteins, though what triggers this misfire isn't fully understood. In some cases certain medications, other autoimmune conditions, or genetic factors are believed to play a role. It's not caused by anything you did, like diet or lifestyle choices.
What should I do if my results are abnormal?
If your results come back elevated, it's important to seek medical care soon so the type and severity of the condition can be properly evaluated, since untreated pemphigus can lead to serious skin and mouth complications. In the meantime, protect any open sores from further irritation and keep them clean to reduce infection risk. If you notice rapidly spreading blisters, fever, or signs of infection, seek medical care right away.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

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Demo results
Desmoglein 3 Antibody 32 U/mL
Demo results
Negative (<20 U/mL) Positive (≥20 U/mL)
32 U/mL

What this means

This result is above the negative threshold, suggesting the presence of antibodies that target skin proteins. This pattern is often seen in pemphigus vulgaris, especially when mouth sores are present.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
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Desmoglein Antibodies Test for Pemphigus Diagnosis

  • Detect autoimmune causes of skin blistering
  • Check for recurring mouth sore triggers
  • Screen for pemphigus antibody activity
$429
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.