What's this test for?

This test is ideal if you're experiencing skin discoloration, painful sores, or numbness in your fingers and toes when you're exposed to cold temperatures. It's also useful if you've noticed unexplained bruising, ulcers, or circulation problems that seem to flare up in cold weather. Cryofibrinogen testing helps identify whether abnormal proteins in your blood are clumping together in the cold and blocking small blood vessels.

What's included in this test?

This test measures cryofibrinogen, an abnormal protein complex that can form clumps in your blood when it gets cold, potentially blocking small blood vessels. Checking for this helps explain cold-triggered skin, joint, or circulation symptoms that don't have an obvious cause. It's often run alongside a cryoglobulin test since the two conditions can occur together and need to be told apart.

What happens after I get my results?

Your results will show up in your secure account with a clear explanation of what a normal range looks like for this test. If your result comes back positive, simple next steps include keeping warm, avoiding cold exposure, and retesting to confirm the finding, since results can occasionally be a temporary reaction. If your result is significantly abnormal along with severe symptoms like skin ulcers or sudden numbness, seek medical care right away. You can download a standard lab report from your account anytime, and the trends feature lets you track this marker over time if you retest in the future.

Who should consider this test?

Consider this test if you notice your skin turning purple or blue, or your extremities going numb specifically when it's cold outside. People with unexplained joint pain, skin sores, or circulation issues that worsen in winter may also benefit. It's a helpful option if previous testing hasn't found a clear cause for these cold-related symptoms.

What symptoms indicate I may need this test?

Common symptoms include skin that turns red, purple, or blue in the cold, painful or numb fingers and toes, unexplained bruising, and slow-healing skin sores or ulcers. Some people also notice joint pain or muscle aches that get worse in cold weather. If these symptoms show up mainly when you're cold and improve once you warm up, this test may help explain why.

How can I naturally support healthy circulation?

Staying warm is one of the simplest things you can do — wear layers, gloves, and warm socks, and avoid sudden temperature drops. Regular movement and light exercise help keep blood flowing well to your hands and feet. Staying hydrated and cutting back on smoking or nicotine, which narrows blood vessels, can also make a noticeable difference.

What is cryofibrinogen and why does it matter?

Cryofibrinogen is a protein complex made up of fibrinogen, fibronectin, and sometimes other proteins that can clump together when your blood gets cold. In some people, this clumping can temporarily block small blood vessels, leading to skin and circulation symptoms. It matters because it can point to an underlying condition even when standard blood work looks normal.

What does a positive cryofibrinogen result mean?

A positive result means these abnormal protein clumps were found in your blood sample, which can explain cold-triggered skin or circulation symptoms. It doesn't automatically mean something serious is going on — some people have low levels without major symptoms. Your report will explain how your specific level compares to a normal range.

What causes an abnormal cryofibrinogen result?

Cryofibrinogen can show up on its own or alongside other conditions that affect the immune system, blood vessels, or connective tissue. Infections, inflammation, and certain immune-related conditions are common contributors. Cold exposure itself doesn't cause the protein to form — it just triggers the clumping in people who already have it in their blood.

How often should I retest?

If your first result is positive, retesting after a few weeks can help confirm the finding, since levels can fluctuate. If you're managing symptoms with lifestyle changes like staying warm, retesting each season change can help you track whether your levels are improving. Your trends feature makes it easy to see these changes over time.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Cryofibrinogen Test - Cold Sensitivity & Circulation

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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