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Allergy cross-reactivity test for people confused by peanut or tree nut IgE results

CCD and Profilin IgE Cross-Reactivity Allergy Test

CCD and Profilin IgE Cross-Reactivity Panel

  • Clarify confusing peanut allergy results
  • Detect pollen-related cross-reactivity issues
  • Screen false-positive tree nut allergies
$121
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you're experiencing confusing allergy test results, such as testing positive for peanut or tree nut IgE antibodies but never having an actual reaction when eating these foods. It helps explain why some people show antibodies on standard allergy panels without having a real food allergy. This is especially useful as a follow-up when peanut or tree nut component testing comes back negative but a broader panel suggested sensitivity.

What's included in this test?

This panel checks for antibodies to CCD (cross-reactive carbohydrate determinants) and profilin, two plant-based proteins known for causing false-positive results on typical nut allergy tests. These markers help distinguish true food allergy from harmless antibody cross-reactivity often triggered by pollen exposure. Understanding this difference matters because it can prevent unnecessary food avoidance.

What happens after I get my results?

Your results will be available in your account, with each marker's normal range clearly explained so you understand what the numbers mean. If your results show cross-reactivity rather than true allergy, you may not need to avoid the food in question, though any major dietary changes are worth introducing gradually. A downloadable standard lab report is also available in your account for your records. You can track these results over time using the trends feature, which is helpful if you retest in the future.

How can I naturally support healthy immune and allergy responses?
Reducing overall inflammation through a balanced diet rich in fruits, vegetables, and omega-3 fatty acids can support a calmer immune system. Managing pollen exposure, especially during high-pollen seasons, may reduce cross-reactive antibody responses tied to profilin sensitivity. Staying hydrated and getting enough sleep also helps your body regulate immune responses more effectively. Some people find relief from mild seasonal symptoms with saline nasal rinses or local honey, though results vary by person.
When will I get my results?
Results are typically ready within about 7 days of your lab visit. Once ready, they will be uploaded securely to your account, where you can view and download them at any time.
Who should consider this test?
This test is a good fit for anyone who tested positive for peanut or tree nut IgE but has never had an allergic reaction to these foods. It's also useful for people with seasonal pollen allergies who want to understand whether their nut-related antibody results are linked to pollen cross-reactivity rather than true food allergy. Anyone seeking clarity before making major dietary changes based on unclear allergy results may benefit.
What symptoms indicate I may need this test?
If you've had positive allergy tests for peanuts or tree nuts but have eaten these foods without any reaction, this test can help explain the mismatch. Mild mouth itching or tingling after eating certain fresh fruits or vegetables, especially if you also have seasonal pollen allergies, can be a sign of cross-reactivity worth investigating. This test is not meant for people experiencing severe allergic reactions like swelling or difficulty breathing, which need immediate medical care.
What does a positive CCD or profilin result mean?
A positive result usually means your immune system is reacting to proteins found broadly in plants and pollen, not to the specific proteins that cause true nut allergies. This is called cross-reactivity, and it generally does not mean you need to avoid nuts. It's most common in people who also have hay fever or other pollen-related allergies.
How often should I retest?
Retesting isn't usually needed on a routine schedule for this panel since cross-reactivity patterns tend to stay fairly stable. You might consider retesting if your symptoms change significantly or if you're reconsidering a food you've been avoiding. Tracking results over time in your account can help you and any specialists notice patterns if you do retest.
What should I do if my results are unclear or concerning?
If your results seem confusing or you're unsure what they mean for your diet, the report explains what each value indicates in plain language. For anyone with a history of severe reactions, it's safest to continue avoiding suspect foods regardless of cross-reactivity results and seek medical care immediately if a severe reaction ever occurs. Otherwise, use these results as one more piece of information when making food choices.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

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Demo results
Profilin IgE (Cross-Reactivity Marker) Positive
Demo results
Negative Positive
Positive

What this means

A positive result means your immune system reacts to profilin, a protein found broadly in plants and pollen, rather than the specific proteins linked to true nut allergy. This commonly explains why someone can test positive for peanut or tree nut IgE without ever having a reaction to eating them. It is frequently seen in people who also have pollen-related seasonal allergies.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
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CCD and Profilin IgE Cross-Reactivity Allergy Test

  • Clarify confusing peanut allergy results
  • Detect pollen-related cross-reactivity issues
  • Screen false-positive tree nut allergies
$121
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.