Why Private MD Labs?
90-day money-back guarantee Lab order in minutes Save a trip to the doctor Low prices since 2005 Labs within 2 miles
Specialized neurological blood test for diagnosing NMO and MS-like symptoms

AQP4 Antibody Test for NMO and MS-like Symptoms

Aquaporin-4 (AQP4) Antibody (NMO-IgG), ELISA

  • Screen for neuromyelitis optica symptoms
  • Detect nerve-damaging antibody presence
  • Clarify confusing MS-like symptoms
$2697
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay
  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

What's this test for?

This test is ideal if you're experiencing unexplained vision loss, eye pain, muscle weakness, numbness, or bladder problems that your symptoms suggest could be neuromyelitis optica (NMO) or a similar condition. It helps distinguish NMO from multiple sclerosis (MS), since the two conditions can look similar but need different management approaches. If you've had unclear neurological symptoms and want a clearer answer about the cause, this test can help.

What's included in this test?

This test measures a single, highly specific antibody in your blood that's linked to neuromyelitis optica. Checking for this antibody matters because it helps separate NMO from other conditions with similar symptoms, like MS, which is important since treatments for each differ significantly.

What happens after I get my results?

Your results will be available in your account, with each value's normal range clearly explained so you understand what it means. If your result is positive, the next step is typically further evaluation to confirm the diagnosis and start the right approach for your situation, so seek medical care promptly if you have severe or worsening symptoms like vision loss or trouble walking. You can download a standard lab report from your account at any time, and if you retest in the future, the trends feature lets you track any changes over time.

How can I naturally support nervous system health?
While there's no natural remedy that treats NMO or related antibody conditions, supporting your nervous system with a balanced diet rich in omega-3 fatty acids, B vitamins, and antioxidants can help overall nerve health. Regular gentle exercise, good sleep, and stress management may also support recovery and general wellbeing. These steps are supportive habits, not substitutes for addressing a positive result promptly.
When will I get my results?
Results for this test are typically ready within about 7 days of your sample being collected. You'll receive a notification once your results are posted to your secure online account, where you can view and download them.
Who should consider this test?
Anyone with recurring episodes of optic nerve inflammation, unexplained limb weakness or numbness, or bladder and bowel control issues that suggest a neurological cause should consider this test. It's especially useful if you or your prior evaluations raised the possibility of NMO or an MS-like condition needing more clarity. People already diagnosed with MS whose symptoms don't fit the typical pattern may also benefit from this check.
What symptoms indicate I may need this test?
Common symptoms that suggest this test could help include sudden vision loss or eye pain, weakness or numbness in the arms or legs, and problems controlling the bladder or bowels. Some people also experience uncontrollable hiccups, nausea, or vomiting due to nerve involvement in this condition. If these symptoms come and go in episodes, that pattern is worth investigating with this test.
What does a positive result mean?
A positive result means the specific antibody linked to NMO was detected in your blood, which strongly supports a diagnosis of neuromyelitis optica rather than MS or another condition. This is an important distinction because NMO often requires a different treatment approach to prevent further nerve damage. If your result comes back positive, seek medical care promptly to discuss next steps and treatment options.
What does a negative result mean?
A negative result means this specific antibody wasn't found in your blood, which makes NMO less likely as the cause of your symptoms, though it doesn't rule it out completely in rare cases. Your symptoms may still need further investigation to identify the actual cause, especially if they are ongoing or worsening. Keep track of your symptoms and consider retesting or additional evaluation if things don't improve.
How often should I retest?
Retesting isn't usually needed on a routine schedule for this specific antibody unless your symptoms change or a first result was inconclusive. If you were previously negative but develop new or worsening neurological symptoms, retesting can help clarify what's going on. Use the trends feature in your account to keep a record if you do retest over time.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Aquaporin-4 (AQP4) Antibody (NMO-IgG) Negative
Demo results
Negative Positive
Negative

What this means

A negative result means the AQP4 antibody was not detected in your blood, making neuromyelitis optica less likely as the cause of your symptoms. This is a reassuring finding, though it doesn't fully rule out NMO in rare cases if symptoms persist.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Find a lab near you

Search Quest Diagnostics and LabCorp locations available through Private MD Labs.

Find a lab

AQP4 Antibody Test for NMO and MS-like Symptoms

  • Screen for neuromyelitis optica symptoms
  • Detect nerve-damaging antibody presence
  • Clarify confusing MS-like symptoms
$2697
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
Ask Me Anything

Your 24/7 Personal Lab Guide

Hi. Tell me what you want to check. I'll find the right blood test for you.

Just now
For informational purposes only. Not medical advice.