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ANA antibody cascade test for autoimmune symptoms like joint pain and fatigue

ANA Antibody Cascade Test for Autoimmune Symptoms

ANA Multiplex with Reflex to 11 Antibody Cascade

  • Screen for autoimmune disease markers
  • Check causes of joint pain
  • Detect unexplained fatigue triggers
$49
LegitScript certified merchant
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

  • Many results come back overnight *
  • 90-day money back guarantee
  • Save time & skip the doctor’s office
  • Lab visit as quick as 10 minutes
  • Results explained, with clear next steps
  • LegitScript certified
  • No questions asked refunds
  • The price you see is the price you pay

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you're experiencing joint pain, unexplained fatigue, skin rashes, or muscle aches that won't go away. These symptoms can sometimes point to an autoimmune condition where the body's immune system mistakenly attacks its own tissues. This panel helps screen for signs of autoimmune rheumatic diseases like lupus, Sjogren syndrome, and rheumatoid arthritis so you can understand what might be causing your symptoms.

What's included in this test?

This test starts with a broad autoimmune antibody screen, then automatically moves through additional tiers of more specific antibody tests only if the initial screen comes back positive. Each tier looks for different antibody patterns linked to specific autoimmune conditions, so the test can help pinpoint which disease process might be involved rather than just flagging that something is off. This tiered approach gives you more useful information while keeping the initial test simple and affordable.

What happens after I get my results?

Your results will show up in your account with an explanation of what a positive or negative result means. If your screening result is positive, the lab automatically runs additional follow-up antibody tests to help narrow down which condition might be involved, so you get more detailed information without ordering a separate test. The full lab report is available to download from your account anytime, and you can track any future retests over time using the trends feature. If your results raise concerns, especially alongside ongoing symptoms, following up with additional testing sooner rather than later is a smart next step.

How can I naturally support my immune system?
While you can't cure an autoimmune condition through lifestyle alone, some habits may help reduce inflammation and support overall immune balance. Eating a diet rich in vegetables, omega-3 fats, and whole foods while limiting processed foods and added sugar can help lower inflammation levels. Getting consistent sleep, managing stress through activities like walking or meditation, and staying active with low-impact exercise can also make a noticeable difference in how you feel day to day.
When will I get my results?
Results are typically ready within about 7 days of your lab visit. If your initial screen is positive, the additional cascade testing happens automatically, which may add a little extra time before your final results are complete. You'll be notified as soon as your results are ready to view in your account.
Who should consider this test?
This test is a good fit for anyone with ongoing, unexplained symptoms like joint pain, fatigue, skin rashes, or muscle weakness that have lasted for weeks or months. It's also useful if autoimmune disease runs in your family and you want a baseline check. People who've had inconclusive symptom patterns that don't fit a clear diagnosis often use this test as a starting point.
What symptoms indicate I may need this test?
Common symptoms that suggest autoimmune involvement include joint pain and stiffness, persistent fatigue that doesn't improve with rest, unexplained skin rashes (especially ones that worsen in sunlight), dry eyes or mouth, and muscle weakness. Fevers with no clear cause and hair thinning can also be signs worth checking. If you have several of these symptoms together, this test can help clarify what's going on.
What does a positive result mean?
A positive result means antibodies were detected that your immune system shouldn't normally be producing against its own tissues. This doesn't automatically mean you have an autoimmune disease, since some healthy people can test positive too, but combined with your symptoms it can point toward conditions like lupus or Sjogren syndrome. The follow-up cascade testing included in this panel helps narrow down which specific condition is most likely.
What does a negative result mean?
A negative result means none of the antibodies included in the screening panel were detected in your blood at the time of testing. This makes an autoimmune rheumatic disease less likely, though it doesn't completely rule one out, since some conditions and early-stage disease can sometimes still be present despite a negative screen. If your symptoms continue or get worse, retesting or exploring other causes may be worthwhile.
How often should I retest?
If your results are negative but symptoms persist or worsen, retesting after a few months can help catch any changes early. If you're positive and being monitored for an autoimmune condition, retesting frequency really depends on how your symptoms are progressing, but every 6-12 months is a common approach for tracking trends. Keeping a symptom diary alongside your test results can help you and any care team notice patterns over time.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Antinuclear Antibodies (ANA) Screen Negative
Demo results
Negative (Normal) Positive (Antibodies Detected)
Negative

What this means

A negative result means no autoimmune antibodies were detected in the screening panel, which makes an autoimmune rheumatic disease less likely. This is a reassuring result, especially if paired with mild or improving symptoms.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Find a lab near you

Search Quest Diagnostics and LabCorp locations available through Private MD Labs.

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ANA Antibody Cascade Test for Autoimmune Symptoms

  • Screen for autoimmune disease markers
  • Check causes of joint pain
  • Detect unexplained fatigue triggers
$49
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.