What's this test for?

This test is ideal if you're experiencing unexplained fatigue, weight loss, low blood pressure, or dark patches of skin that won't go away. These can be signs that your immune system is mistakenly attacking your adrenal glands, a condition linked to Addison's disease. It's also useful if you already have one autoimmune condition and want to check for others that sometimes occur together.

What happens after I get my results?

Your results will be available in your account, with each value's normal range clearly explained so you know exactly where you stand. If your antibody level comes back elevated, next steps typically include retesting to confirm the result and watching for symptoms like fatigue, salt cravings, or dizziness, and seeking medical care right away if you experience severe weakness, vomiting, or fainting. You can download a standard lab report anytime, and if you test again in the future, the trends feature lets you track changes over time.

What's included in this test?

This test measures 21-Hydroxylase Antibody, a specific antibody that attacks an enzyme your adrenal glands need to produce hormones like cortisol and aldosterone. Checking for this antibody helps identify autoimmune activity against the adrenal glands before more serious hormone deficiencies develop, and it can also flag risk for autoimmune polyglandular syndrome.

How can I naturally support adrenal health?

While you can't reverse autoimmune antibody activity with lifestyle changes alone, supporting your body's stress response can help you feel better day to day. Eating regular, balanced meals, staying well hydrated, prioritizing sleep, and managing stress through activities like walking or meditation all support healthy adrenal function. Avoid excessive caffeine and intense unmanaged stress, which can strain adrenal hormone output further.

When will I get my results?

Results are typically ready within about 7 days of your lab visit. Once processed, they'll be uploaded directly to your secure online account, and you'll be notified as soon as they're ready to view.

Who should consider this test?

This test is a good fit for anyone with symptoms of adrenal insufficiency, such as persistent fatigue, weight loss, or low blood pressure. It's also worth considering if you have another autoimmune condition, like type 1 diabetes or thyroid disease, since these can cluster together in autoimmune polyglandular syndrome. People with a family history of Addison's disease may also want to check their status.

What symptoms indicate I may need this test?

Common warning signs include ongoing fatigue that doesn't improve with rest, unexplained weight loss, low blood pressure, salt cravings, and darkening of the skin, especially in creases or scars. Nausea, dizziness upon standing, and low mood can also point to adrenal issues. If you notice several of these together, it's worth checking your antibody status.

What does a high antibody result mean?

A high result means your immune system is producing antibodies that attack your adrenal glands, which can eventually reduce their ability to make essential hormones. This doesn't always mean you have Addison's disease yet, but it does mean your adrenal function should be monitored closely over time. Retesting and tracking symptoms like fatigue and blood pressure changes can help catch problems early.

How often should I retest?

If your first result is positive or borderline, retesting every 6 to 12 months is a reasonable starting point to watch for changes. If you're symptom-free and your levels are stable, less frequent retesting may be appropriate. Always retest sooner if new symptoms like severe fatigue or fainting appear.

What should I do if my results are abnormal?

If your antibody levels come back elevated, start by tracking your symptoms, especially fatigue, weight changes, and blood pressure. Make sure you're eating well, staying hydrated, and managing stress, since these support overall adrenal function. If you experience severe symptoms like vomiting, extreme weakness, or fainting, seek medical care immediately, as this can signal a serious adrenal crisis.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

21-Hydroxylase Antibody Test - Adrenal Autoimmune Check

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]

21-Hydroxylase Antibody Test for Adrenal Health