Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Interstitial cystitis (IC), also known as painful bladder syndrome, is a chronic condition characterized by bladder pressure, bladder pain, and sometimes pelvic pain. There is no single blood test that can diagnose interstitial cystitis; however, lab testing plays a fundamental role in the diagnostic process by ruling out other conditions with similar symptoms.
This test is crucial in the diagnostic workup for interstitial cystitis as it helps rule out urinary tract infections and other bacterial causes of bladder symptoms. Since IC symptoms can mimic those of a UTI, a negative urine culture supports the consideration of interstitial cystitis as a potential diagnosis.
The symptoms of interstitial cystitis often overlap with other urological conditions, particularly urinary tract infections (UTIs). Since IC diagnosis is primarily based on excluding other causes of bladder pain and urinary symptoms, lab testing is essential for ensuring an accurate diagnosis and appropriate treatment plan.
Diagnosing interstitial cystitis is typically a process of elimination. Healthcare providers use lab tests like urine culture to exclude infections and other treatable conditions. When these tests come back negative but symptoms persist, it strengthens the case for an IC diagnosis, which may then be confirmed through additional clinical evaluation and specialized procedures.
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.