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Fetal death, also known as stillbirth, is the loss of a baby before or during delivery after 20 weeks of pregnancy. It is caused by complications including placental problems, infections, chromosomal abnormalities, maternal health conditions, or umbilical cord accidents that compromise oxygen and nutrient delivery to the fetus. The Estriol LC/MS/MS Serum test is the most important blood test for detecting pregnancy complications because significantly low estriol hormone levels can indicate fetal distress or impending loss.
Fetal death is caused by multiple factors including placental abruption or insufficiency, maternal infections like cytomegalovirus or listeria, chromosomal abnormalities such as trisomy 13 or 18, maternal health conditions like uncontrolled diabetes or preeclampsia, and umbilical cord accidents that cut off oxygen supply. Placental problems are the most common cause, preventing the baby from receiving adequate oxygen and nutrients. In many cases, the exact cause remains unknown even after thorough investigation, making regular prenatal monitoring essential for identifying risk factors early.
The Estriol LC/MS/MS Serum test is the most important blood test for detecting pregnancy complications that may lead to fetal death because it measures estriol hormone levels produced by both the placenta and the developing baby. Significantly low estriol levels can indicate serious fetal distress, placental dysfunction, or impending loss before other symptoms appear. This advanced laboratory test provides critical information for healthcare providers to assess pregnancy health and determine if additional monitoring or intervention is needed. While ultrasound imaging is the primary diagnostic tool for confirming fetal death, estriol testing serves as a valuable early warning system for complications.
You should get tested if you notice decreased fetal movement after 28 weeks, experience vaginal bleeding or unusual cramping during the second or third trimester, have risk factors like diabetes or high blood pressure, develop sudden severe abdominal pain, or feel that something is wrong with your pregnancy. Any decrease in your baby's normal movement pattern requires immediate medical evaluation. Women with previous pregnancy losses, multiple gestations, or advanced maternal age should consider more frequent monitoring including hormone testing to catch potential complications early.
What this means
Your estriol level is below the typical range for this stage of pregnancy. While this may be normal for some healthy pregnancies, it could indicate that further evaluation is needed to ensure optimal fetal and placental health. Your obstetrician will interpret this result alongside your ultrasound findings and other prenatal screening results.
Recommended actions
Follow up with your obstetrician to discuss results and any additional testing needed
Ensure you're attending all scheduled prenatal appointments for comprehensive monitoring
Maintain a healthy pregnancy diet with adequate protein, healthy fats, and prenatal vitamins
Your doctor may recommend retesting in 1-2 weeks to monitor trends
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