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Genetic cancer risk test for families with Von Hippel-Lindau syndrome history

VHL Gene Test for Von Hippel-Lindau Syndrome Risk

VHL Sequencing and Deletion/Duplication

  • Screen for inherited kidney cancer risk
  • Detect Von Hippel-Lindau gene changes
  • Assess family cancer risk history
$1360
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you're concerned about a family history of Von Hippel-Lindau syndrome or related tumors like kidney cancer, pancreatic growths, or eye and brain tumors. It helps if you have relatives diagnosed with these conditions and want to understand your own genetic risk. Knowing your VHL gene status can guide decisions about future health monitoring and screening.

What's included in this test?

This test looks closely at the VHL gene to find changes, called pathogenic variants, that are linked to Von Hippel-Lindau syndrome. It examines both small changes within the gene's sequence and larger missing or duplicated sections, since either type can disrupt how the gene works and raise tumor risk. This thorough approach helps catch a wide range of possible genetic changes that a single test method alone might miss.

What happens after I get my results?

Your results will be available in your secure account, with an explanation of what a positive or negative finding means for VHL-related risk. If a pathogenic variant is found, the report outlines next steps, such as more frequent screening for kidney, pancreatic, or eye abnormalities. The full lab report can be downloaded directly from your account for your personal records. Since this is a one-time genetic test, there's no need for retesting, but you can keep the report saved and accessible through your account over time.

How can I naturally support kidney and organ health?
While genetics can't be changed through diet or lifestyle, supporting your kidneys, pancreas, and overall organ health with good habits is still worthwhile. Staying well-hydrated, limiting excess salt and processed foods, avoiding smoking, and maintaining a healthy weight all support kidney function. Regular exercise and a diet rich in fruits, vegetables, and whole grains can also help your body manage inflammation and stay resilient. These habits won't change your genes, but they support your body's overall function while you follow any recommended screening schedule.
When will I get my results?
Results for this test are typically ready within about 7 days of your sample being received at the lab. Genetic tests like this one require careful analysis, which is why the turnaround is longer than routine blood work. You'll get a notification as soon as your results are posted to your account so you can review them right away.
Who should consider this test?
This test is a good fit if you have a personal or family history of kidney cancer, pancreatic neuroendocrine tumors, retinal angiomas, hemangioblastomas, or pheochromocytoma. It's also worth considering if a close relative has already been diagnosed with Von Hippel-Lindau syndrome and you want to know your own genetic risk. People planning their families who want to understand inherited risk factors may also benefit from this testing.
What symptoms indicate I may need this test?
Signs that might prompt this test include recurring cysts or tumors in the kidneys or pancreas, vision changes from retinal growths, or unexplained high blood pressure linked to adrenal gland tumors. Headaches, balance problems, or coordination issues tied to brain or spinal tumors can also be relevant symptoms. If you or a close family member have experienced several of these issues, genetic testing can help clarify whether VHL is the underlying cause.
What is VHL and why does it matter?
VHL is a gene that normally works like a quality-control manager, helping stop cells from growing out of control. When this gene has a harmful change, it can't do its job properly, which raises the risk of certain tumors and cysts forming in organs like the kidneys, pancreas, eyes, and brain. Understanding your VHL status matters because it can guide how closely you and your doctor watch for these conditions, potentially catching problems early when they're easier to manage.
What does a positive VHL result mean?
A positive result means a pathogenic variant was found in your VHL gene, which raises your lifetime risk of developing tumors in organs such as the kidneys, pancreas, adrenal glands, eyes, or brain. It does not mean you currently have cancer or will definitely develop it, but it does mean increased vigilance is wise. Many people with a positive result benefit from more frequent imaging and eye exams to catch any growths early.
What should I do if my results are abnormal?
If your results show a pathogenic VHL variant, the most useful next step is setting up a proactive screening routine, such as regular kidney imaging, eye exams, and blood pressure checks. Sharing your results with close biological relatives can also help them decide if they want to get tested, since VHL variants can be inherited. If you notice new or worsening symptoms like vision changes or severe headaches, seek medical care promptly.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
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Results start landing the next day after your lab visit.*
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Fast & confidential, we never sell or share your data
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Demo results
VHL Gene Pathogenic Variant Negative
Demo results
Negative Positive
Negative

What this means

A negative result means no pathogenic VHL gene variants were detected, so your genetic risk for Von Hippel-Lindau syndrome from this gene is low. This does not rule out all cancer risk, but it means you don't carry a known VHL mutation linked to this syndrome. A positive result would indicate a variant is present, raising your lifetime risk for related tumors.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
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Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
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Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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VHL Gene Test for Von Hippel-Lindau Syndrome Risk

  • Screen for inherited kidney cancer risk
  • Detect Von Hippel-Lindau gene changes
  • Assess family cancer risk history
$1360
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.